Penn Veterinary Medicine | University of Pennsylvania

Description of Research Expertise

Measuring hypoxia in vivo
Animal Models of human disease
Cancer physiology, proliferation
Cancer physiology, tumor vasculature

Description of Clinical Expertise

Measuring hypoxia and predicting treatment response in brain tumors
Measuring hypoxia and predicting treatment responsein cervix cancer
Measuring hypoxia and predicting treatment responsein head and neck squamous cell carcinoma
Measuring hypoxia and predicting treatment responsein carcinomatosis and sarcomatosis
Measuring hypoxia and predicting treatment responsein pleural cancers
Measuring hypoxia and predicting treatment response in soft tissue sarcomas

Description of Other Expertise

Mentoring junior faculty
Mentoring women

Selected Publications

Lilie L Lin, LL Antti Silvoniemi James B Stubbs Ramesh Rengan Sami Suilamo Olof Solin Chaitanya Divgi Olli Eskola Jonathan M. Sorger Michael G. Stabin Alexander Kachur Stephen M. Hahn Tove Grönroos Sarita Forsback Sydney M Evans Cameron J. Koch Heikki Minn: Radiation Dosimetry and Biodistribution of the Hypoxia Tracer 18F-EF5 in Oncologic Patients. Cancer Biotherapy & Radiopharmaceuticals 27(7): 412-9, Sep 2012.

Marotta D, Karar J, Jenkins WT, Kumanova M, Tobias JW, Baldwin D, Hadjigeorgiou A, Alexiou P, Evans SM, Alarcon R, Maity A, Koch CJ, Koumenis C: In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection. Cancer Research 71(3): 779-89, (eds.). Feb 1 2011 .

Evans SM, Jenkins KW, Chen HI, Jenkins WT, Judy KD, Hwang W-T, Lustig RA, Judkins AR, Grady MS, Hahn SM, Koch CJ: The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study. Translational Oncology 3(3): 160–9, Jun 2010 .

Koch CJ, Scheuermann JS, Divgi C, Judy KD, Kachur A, Freifelder R, Saffer J, Karp J, Stubbs JM, Hahn SM, Driesbaugh J, Smith D, Prendergast S, Evans SM: Biodistribution and dosimetry of 18F-EF5 in cancer patients with preliminary comparison of 18F-EF5 uptake versus EF5 binding in human glioblastoma. European Journal of Nuclear medicine and Molecular Imaging 37(11): 2048-59, Nov 2010.

Koch CJ, Shuman AL, Jenkins WT, Kachur AV, Karp JS, Freifelder R, Dolbier WR, Evans SM: The radiation response of cells from 9L gliosarcoma tumors is correlated with [F18]-EF5 uptake. International Journal of Radiation Biology 85(12): 1137-47, Dec 2009 .

Cerniglia G, Pore N, Tsai JH, Schultz S, Mick R, Regine C, Xiaoman X, Durduran T, Yodh AG, Evans SM, Koch CJ, Hahn SM, Quon H, Sehgal CM, Lee W M-F, Maity A: Epidermal growth factor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PloS one 4(8): e6539, Aug 6 2009.

Komar G, Seppänen M, Eskola O, Lindholm Paula, Grönroos T, Forsback S, Sipilä H, Evans SM, Solin O, Minn H: 18F-EF5: A new PET tracer for imaging hypoxia in head and neck cancer. Journal of Nuclear Medicine 49(12): 1944-51, Dec 2008.

Evans, SM, Jenkins KW, Jenkins WT, Dilling T, Judy KD, Schrlau A, Judkins A, Hahn SM, Koch CJ: Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors. Radiation Research 170(6): 677-90, Dec 2008.

Ellinwood NM, Colle MA, Weil M. A., Casal ML, Vite CH, Weimelt S, Hasson CW, O'Malley TM, He X, Prociuk U, Verot L, Melniczek JR, Lannon A, Aguirre GD, Knox VW, Evans SM, Varnier MT, Schuchman EH, Walkley SU, Haskins ME: Bone marrow transplantation for feline mucopolysaccharidosis I. Molecular Genetics and Metabolism 91(3): 239-250, July 2007.

Wang H-W, Finlay JC, Lee K, Zhu T, Putt ME, Glatstein E, Koch CJ, Evans SM, Hahn SM, Busch TM, Yodh AG : Quantitative comparison of tissue oxygen and motexafin lutetium uptake by ex-vivo and noninvasive in-vivo techniques in patients with intraperitoneal carcinomatosis. Journal of Biomedical Optics 126(3): 23-34, May-Jun 2007.