Director of Metabolic Genetics Screening Laboratory
Head of Clinical Program in Medical Genetics and Pediatrics
Secondary Appointment as (Assistant/Associate/Full) Professor of Medicine
Charlotte Newton Sheppard Chair of Medicine
Director, Josephine Deubler Genetic Disease Testing Laboratory, University of PennsylvaniaContact Information
Section of Medical Genetics
University of Pennsylvania
School of Veterinary Medicine
3900 Delancey Street
Philadelphia, PA 19104-6010
DVM (Veterinary Medicine) Veterinär-Medizinische Fakultät, University of Zürich, 1977
PD (Internal Medicine) University of Zürich, Switzerland, 1989
MS (Comparative Sciences) University of Pennsylvania, Philadelphia, 1990
Description of Research Expertise
Clinical Genetics, Hematology, Transfusion Medicine, Animal Models of Human Disease
Description of Clinical Expertise
Clinical Genetics, Hematology, and Transfusion Medicine in Companion Animals
Description of Other Expertise
Urs Giger received his veterinary degree from the University of Zürich, Switzerland, where he also pursued his initial clinical training in small animal medicine and surgery and a doctoral thesis on the orthopedic correction of canine hip dysplasia. In 1981, he moved initially as a postdoctoral fellow to the United States, where he subsequently completed a residency in small animal internal medicine at the University of Florida.
He then joined the faculty of the School of Veterinary Medicine at the University of Pennsylvania in Philadelphia and has been over the years a clinician in the Medicine, Oncology, and Pediatrics/Genetics Service. He is currently the Charlotte Newton Sheppard Professor of Medicine and was the Head of Medical Genetics until 2008. He has a secondary professorship in internal medicine at the University of Zürich as well as a joint professorship in hematology at the School of Medicine of the University of Pennsylvania. He is a diplomate of the American and European College of the Veterinary Internal Medicine as well as a diplomate of the European College of Clinical Pathology. He is a clinician in medicine, hematology, pediatrics, and genetics and is heading the Pediatrics and Genetics Clinic, the Metabolic Genetics Laboratory, the Josephine Deubler Genetic Disease Testing Laboratory (PennGen), and the Transfusion Medicine (-2009) at the University of Pennsylvania. His clinical and research expertise and interests are in hereditary and hematologic disorders of small animals (including transfusion medicine) and are reflected in over 170 original research publications as well as many more reviews, chapters, and scientific abstracts. He also coedited the book "The Dog and Its Genome" from Cold Spring Harbor Laboratory Press. Among others awards, he was the recipient of the 2002 International Scientific Lifetime Achievement Award from the World Small Animal Veterinary Association and the 2007 International Bourgelat Award from the BSAVA and is a frequently invited speakers at national and international conferences.
Inal Gultekin G, Raj K, Lehman S, Hillström A, Giger U.: Missense mutation in PFKM associated with muscle-type phosphofructokinase deficiency in the Wachtelhund dog. Molecular Cell Probes Page: epub, 2012.
Seth M, Jackson K,V, Winzelberg S, Giger U: Comparison of gel column, card and cartridge techniques for Dog Erythrocyte Antigen Am J Vet Res 73: 213–219, 2012.
Inal Gultekin G, Raj K, Foureman P, Lehman S, Manhart K, Abdulmalik O, Giger U.: Erythrocytic pyruvate kinase mutations causing hemolytic anemia, osteosclerosis, and secondary hemochromatosis in dogs.
J Vet Intern Med 26(4): 935–944, Jul 2012.
Jolly RD, Hopwood JJ, Marshall NR, Jenkins KS, Thompson DJ, Dittmer KE, Thompson JC, Fedele AO, Raj K, Giger U.: Mucopolysaccharidosis type VI in a Miniature Poodle-type dog caused by a deletion in the arylsulphatase B gene.
NZ Vet J 60(3): 183-188, May 2012.
Seth M, Jackson KV, Giger U: Comparison of 5 blood typing methods for the feline AB blood group system. Am J Vet Res 72: 203-9, Feb 2011.
Patterson J, Rousseau A, Kessler RJ, Giger U: In vitro lysis and acute transfusion reactions with hemolysis caused by inappropriate storage of canine red blood cell products J Vet Intern Med 25: 927-933, 2011.
Clavero S, Bishop DF, Giger U, Haskins ME, Desnick RJ: Feline congenital erythropoietic porphyria: Two homozygous UROS missense mutations cause the enzyme deficiency and porphyrin accumulation. Mol Med 16: 381-8, 2010.
Clavero S, Bishop DF, Haskins ME, Giger U, Kauppinen R, Desnick RJ: Feline acute intermittent porphyria: a phenocopy masquerading as an erythropoietic porphyria due to dominant and recessive hydroxymethylbilane synthase mutations. Hum Mol Genet 19: 584-96, 2010.
Margaritis P, Roy E, Aljamali MN, Downey HD, Giger U, Zhou S, Merricks E, Dillow A, Ezban M, Nichols TC, High KA.: Successful treatment of canine hemophilia by continuous expression of canine FVIIa. Blood 113(16): 3682-9, 2009.
Pontius JU, Mullikin JC, Smith DR; Agencourt Sequencing Team, Lindblad-Toh K, Gnerre S, Clamp M, Chang J, Stephens R, Neelam B, Volfovsky N, Schäffer AA, Agarwala R, Narfström K, Murphy WJ, Giger U, Roca AL, Antunes A, Menotti-Raymond M, Yuhki N, Pecon-Slattery J, Johnson WE, Bourque G, Tesler G; NISC Comparative Sequencing Program, O'Brien SJ: Initial sequence and comparative analysis of the cat genome Genome Res. 17: 1675-89, 2007.