Dorothy Cimino Brown

Section of Soft Tissue Surgery

Associate Professor of Surgery, Department of Clinical Studies - Philadelphia

Associate Scholar, Center for Clinical Epidemiology and Biostatistics, School of Medicine

Director, Veterinary Clinical Investigations Center

Chief of Surgery

Contact Information
Section of Surgery
Department of Clinical Studies - Philadelphia
School of Veterinary Medicine
University of Pennsylvania
3900 Delancey Street
Philadelphia, PA 19104-6010

Fax: 215-573-9457

Email:
dottie@vet.upenn.edu

Education

BS (Zoology ) The University of Maryland at College Park, College Park, Maryland, 1988

DVM (Doctor of Veterinary Medicine ) Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia, 1992

MSCE (Master of Science in Clinical Epidemiology) University of Pennsylvania, School of Medicine, Philadelphia, PA, 2006

Description of Research Expertise

Dr Brown currently spends 80% of her time on NIH, industry, and foundation supported research. She focuses primarily on the measurement and management of chronic pain in companion dogs, particularly those with bone cancer and osteoarthritis. In addition, Dr Brown is involved in the development of outcome assessment tools for use in studies of canine chronic pain, orthopedic disease, sleep disturbances, and oral pain. She has a general interest in companion animal clinical trials, reviewing the current status of clinical trial methodology reported in the veterinary literature.

Selected Publications

Brown DC, Boston R, Coyne J, Farrar JT. : The Canine Brief Pain Inventory (CBPI): Development and psychometric testing of an instrument designed to measure chronic pain in companion dogs with osteoarthritis. Am J Vet Res 68: 631-637, 2007.

Brown DC. : Sources and handling of losses-to-followup in parallel group randomized clinical trials in dogs and cats: 63 trials (2000-2005). Am J Vet Res 68: 694-698, 2007.

Brown DC. : Commentary: Outcomes Based Medicine in Veterinary Surgery: How to Get Hard Measures of Subjective Outcomes Vet Surg 36: 289-292 , 2007.

Schultz KS, Cook JL, Kapatkin AS, Brown DC. : Commentary: Evidence Based Surgery – Time for Change Vet Surg 35: 697-699, 2006.

Brown DC.: The control of selection bias in parallel group controlled clinical trials in dogs and cats (2000-2005). J Am Vet Med Assoc 229: 990-993, 2006.

Brown DC. : Evaluating and interpretating clinical trials Comp Cont Ed Pract Vet 27(10): 752-764, 2005.

Brown DC. : Reports of parallel group controlled clinical trials: What needs to be there? J Vet Em Crit Care 15(3): 171-173, 2005.

Brown DC, Iadarola MJ, Perkowski SZ, Hardam E, Shofer F, Mannes AJ.: Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model. Anesthesiol 103: 1052-1059, 2005.

Karai L, Brown DC, Mannes AJ, Connelly ST, Brown J, Gandal M, Wellisch OM, Neubert JK, Olah Z, Iadarola MJ. : Deletion of vanilloid receptor 1 expressing primary afferent neurons for pain control. J Clin Invest 113(9): 1344-1352, 2004.

Mannes AJ, Brown DC, Perkowski SZ, Keller J, Caudle RM, Iadarola MJ, Meng QC. : Measurement of resiniferatoxin in cerebrospinal fluid by high-performance liquid chromatography. J Chromatography B 780: 475-479, 2002.

Dow C, Michel KE, Brown DC. : The impact of sampling interval on the variability of activity counts recorded from the Actical® activity monitor worn by pet dogs September 2007.

Brown, DC, Boston, R, Coyne, JC, Farrar, JT: A Novel Approach to the Use of Animals in Studies of Pain: Validation of the Canine Brief Pain Inventory in Canine Bone Cancer Pain Medicine 10(1): 133-142, 2009.

Dow C, Michel KE, Brown DC: Evaluation of the optimal sampling interval for activity monitoring in companion dogs AJVR 70(4): 444-448, 2009.

Brown DC, Michel KE, Love M: Impact of signalment and body conformation on activity monitoring in companion dogs AJVR In Press.
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