Penn Veterinary Medicine | University of Pennsylvania

Description of Research Expertise

1. Clinical Research involving small animal diagnostic imaging - Evidence-based imaging
2. Vascular imaging: Computed Tomographic Angiography and Magnetic Resonance Angiography, as it applies to the diagnosis of vascular anatomical abnormalities and also functional (perfusion) evaluation of spontaneous lesions, especially neoplastic.
3. Laboratory rodent high resolution diagnostic imaging / non invasive phenotyping using diagnostic imaging. Dr Mai has completed a PhD in biomedical engineering, during which he studied the implementation and role of high-resolution diagnostic imaging to image in vivo laboratory rodents. Techniques involved were high-resolution digital radiography, high-resolution ultrasound, high field MRI and high resolution CT. Dr Mai completed part of his PhD at the Center for In Vivo Microscopy (Durham, NC), a leader in the field of high resolution MRI.

Description of Clinical Expertise

Canine and Feline Diagnostic Imaging, including radiology, ultrasonography, computed tomography and magnetic resonance imaging.

Selected Publications

Eshar D., Briscoe J.A., Mai W.: Radiographic kidney measurements in North American pet ferrets (Mustela furo) Journal of Small Animal Practice 54: 15-19, January 2013.

Reetz J.A., Cáceres A., Suran J.N., Oura T., Zwingenberger A., Mai W.: Sensitivity, positive predictive value and interobserver variability of computed tomography in the diagnosis of bullae and blebs in dogs with spontaneous pneumothorax: 19 cases (2003-2012). Journal of the American Veterinary Medical Association Accepted 2013.

Mai W., Suran J., Caceres A.V., Reetz J.: Comparison between bolus tracking and timing-bolus techniques for renal CT angiography in normal cats. Veterinary Radiology and Ultrasound Accepted 2013.

Guillem Gallach R., Mai W.: Cardiac MRI findings in a dog with a diffuse pericardial mesothelioma and pericardial effusion. Journal of the American Animal Hospital Association Accepted 2013.

Schlicksup M.D., Holt D.E., Mai W., Holmes E.S., Agnello K.A. : The effect of abaxial retraction on pelvic geometry following pelvic symphysiotomy. Veterinary Surgery Accepted 2013.

Paek M., Engiles J.B., Mai W.: Prevalence, association with other stifle conditions, and histopathologic characteristics of tibial tuberosity radiolucencies in dogs. Veterinary Radiology and Ultrasound Accepted 2013.

Seiler G., Robertson I., Mai W., Widmer W., Suran J., Nemanic S., Lamb C., Lang J., Johnson J., Thrall D.: Usefulness of a Half-Fourier acquisition Single-Shot Turbo Spin-Echo pulse sequence in identifying arachnoid diverticula in dogs. Veterinary Radiology and Ultrasound 53: 157-161, 2012.

Kuczynski L.A., Schwartz P., Peddle G., Huang S., Mai W., Giger U. : Goiter with Vascular Anomalies in a Litter of Polish Lowland Sheepdogs. J Am Anim Hosp Assoc. 48: 278-283, 2012.

Kurosaka S., Leu N.A., Pavlov I., Han X., Bretanha-Ribeiro P.A., Xu T., Bunte R., Saha S., Mai W., Yates J.R., Rassier D.E., Kashina A.: Arginylation in cardiomyocytes regulates myofibril properties to maintain heart function and prevent dilated cardiomyopathy. J Mol Cell Cardiol. 53: 333-341, 2012.

Mai W., Weisse C., Sleeper M.M. : Cardiac MRI in normal dogs and two dogs with heart base tumors. Veterinary Radiology and Ultrasound 51: 428-435, September 2011.

Mai W, Sutherland-Smith J.: Academic radiology careers: what is academia all about? Veterinary Radiology and Ultrasound 51(3): 239-45, May-June 2010.

Suran J., Durham A., Mai W., Seiler G. : Contrast enhancement of extradural compressive material on magnetic resonance imaging Veterinary Radiology and Ultrasound 52: 10-16, January 2011.

Cervera V., Mai W., Vite C.H., Johnson V., Dayrell-Hart B., Seiler G.S.: Comparative magnetic resonance imaging findings between gliomas and presumed cerebrovascular accidents in dogs. Veterinary Radiology and Ultrasound 52: 33-40, January 2011.

Mai W., Weisse C.: Contrast-enhanced portal MRA in dogs with suspected congenital portal vascular anomalies. Veterinary Radiology and Ultrasound 52: 284-288, 2011.

Guillem Gallach R., Suran J., Cáceres A.V., Reetz J.A., Brown D.C., Mai W.: Reliability of T2-weighted sagittal MR images for determining the location of compressive disc herniation in dogs. Veterinary Radiology and Ultrasound 52: 479-486, Nov-Dec 2011.

Cavrenne R, Mai W: Time-resolved renal contrast-enhanced MRA in normal dogs Veterinary Radiology and Ultrasound 50(1): 58-64, January 2009.

Mai W: Multi-phase time-resolved contrast-enhanced portal MRA in normal dogs Veterinary Radiology and Ultrasound 50(1): 52-57, January 2009.

Mai W: Pseudo-layering artifact on post-contrast magnetic resonance images of the bladders of 18 dogs and three cats. The Veterinary Record 163: 116-119, July 2008.

Ivancic M., Mai W.: Qualitative and quantitative comparison of renal vs. hepatic ultrasonographic intensity in healthy dogs. Veterinary Radiology and Ultrasound 49(4): 368-373, July-August 2008.

Mai W., Caceres A.V.: Dual-phase computed tomographic angiography in three dogs with pancreatic insulinoma Veterinary Radiology and Ultrasound 49(2): 141-148, February 2008.

Cáceres A.V., Zwingenberger A.L., Aronson L.R., Mai W: Characterization of normal feline renal vascular anatomy with dual-phase CT angiography Veterinary Radiology and Ultrasound 49(4): 350-356, July-August 2008.

Valdés-Martínez A., Seiler G., Mai W., Bolt D.M., Mudge M., Dukti S.A., Hubert J.D. : Quantitative analysis of scintigraphic findings in tibial stress fractures in Thoroughbred racehorses American Journal of Veterinary Research 69(7): 886-890, July 2008.

Valdés-Martínez A., Cianciolo R., Mai W.: Association between renal hypoechoic subcapsular thickening and lymphosarcoma in cats Veterinary Radiology and Ultrasound 48: 357-360, Jul-Aug 2007.

Chuzel T., Couturier L., Nicolier A., Bublot I., Mai W., Cadore J.L. : Persistent truncus arteriosus in a cat Journal of Veterinary Cardiology 9(1): 43-46, May 2007.

Kinns J., Mai W.: Association between malignancy and sonographic heterogeneity in canine and feline abdominal lymph nodes Veterinary Radiology and Ultrasound 48(6): 565-569, Nov-Dec 2007.

Spriet M., Mai W., McKnight A.: Asymmetric signal intensity in normal collateral ligaments of the distal interphalangeal joint in horses with a low-field MRI system due to the magic angle effect Veterinary Radiology & Ultrasound 48(2): 95-100, Mar-Apr 2007.

Kinns J., Mai W., Seiler G., Zwingenberger A., Johnson V., Caceres A., Valdes-Martinez A., Schwarz T.: Radiographic sensitivity and negative predictive value for acute canine spinal trauma Veterinary Radiology & Ultrasound 47(6): 563-70, Oct-Nov 2006.

Wiart M., Carme S., Mai W., Larsson HB., Neyran B., Canet-Soulas E.: In vivo quantification of regional myocardial blood flow: validity of the fast-exchange approximation for intravascular T1 contrast agent and long inversion time Magnetic Resonance in Medicine 56(2): 340-7, Aug 2006.

Mai W.: The hilar perivenous hyperechoic triangle as a sign of acute splenic torsion in dogs Veterinary Radiology & Ultrasound 47(5): 487-91, Sep-Oct 2006.

Reetz JA., Mai W., Muravnick KB., Goldschmidt MH., Schwarz T.: Computed tomographic evaluation of anatomic and pathologic variations in the feline nasal septum and paranasal sinuses Veterinary Radiology & Ultrasound 47(4): 321-7, Jul-Aug 2006.

Carme S., Mai W., Mazzadi A., Janier M., Revel D., Magnin I., Wiart M., Neyran B., Canet-Soulas E.: Importance of parametric mapping and deconvolution in analyzing magnetic resonance myocardial perfusion images Investigative Radiology 41(4): 374-83, Apr 2006.

Mai W., Badea CT., Wheeler CT., Hedlund LW., Johnson GA.: Effects of breathing and cardiac motion on spatial resolution in the microscopic imaging of rodents Magnetic Resonance in Medicine 53(4): 858-65, Apr 2005.

Chuzel T., Bublot I., Mai W.: What is your diagnosis? Primary hyperparathyroidism in a dog Journal of the American Veterinary Medical Association 226(2): 203-4, 2005.

Brown S.D.M., Chambon P., Hrabe de Angelis M. & The EUMORPHIA Consortium: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome Nature Genetics 37: 1155, 2005.

Mai W., Le Floc'h J., Vray D., Samarut J., Barthez P., Janier M.: Evaluation of cardiovascular flow characteristics in the 129Sv mouse fetus using color-Doppler-guided spectral Doppler ultrasound Veterinary Radiology & Ultrasound 45(6): 568-73, Nov-Dec 2004.

Mai W., Barraud L., Lefrancois L., Scoazec JY., Guerret S., Vray D., Merle P., Vitvitski-Trepo L., Trepo C., Janier MF.: Ultrasound detection of spontaneous hepato-cellular carcinomas in X/myc bitransgenic mice Liver International 24(6): 651-7, Dec 2004.

Mai W., Janier MF., Allioli N., Quignodon L., Chuzel T., Flamant F., Samarut J.: Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life Proceedings of the National Academy of Sciences of the United States of America 101(28): 10332-7, Jul 13 2004.

Chuzel TA., Mai W., Ponce FM.: What is your diagnosis? Abdominal distension with loss of intra-abdominal contrast and decreased visibility of serosal surfaces of the small and large intestines Journal of the American Veterinary Medical Association 224(12): 1921-2, Jun 15 2004.

Sappey-Marinier D., Beuf O., Billotey C., Chereul E., Dupuy J., Jeandey M., Grenier D., Hasserodt J., Langlois J.B., Lartizien C., Mai W., Odet C., Samarut J., Vray D., Zimmer L., Janier M. : The ANIMAGE project: a multimodal imaging platform for small animal research. Nucl Instr Meth Phys Res A. 527: 117-123, 2004.

Mai W: Chapter 7 – The Heart and Major Vessels (Contribution: Congenital Cardiac Diseases) BSAVA Manual of Canine and Feline Thoracic Imaging Page: 110-134, Tobias Schwarz and Victoria Johnson (eds.). BSAVA, 2008.

Mai W: Chapter 12 – The Lung Parenchyma (Contribution: Normal Radiographic Aspect of the Lungs) BSAVA Manual of Canine and Feline Thoracic Imaging Page: 242-248, Tobias Schwarz and Vicoria Johnson (eds.). BSAVA Ed, 2008.

Mai W.: Chapter 9 - The Stomach (Contribution: Gastric Radiology) BSAVA Manual of Canine and Feline Abdominal Radiography Page: 87-109, BSAVA Ed. (eds.). Gloucester, England , May 2009.

Mai W., Ledieu D., Venturini L., Fournel C., Fau D., Palazzi X., Magnol JP.: Ultrasonographic appearance of intra-abdominal granuloma secondary to retained surgical sponge Veterinary Radiology & Ultrasound 42(2): 157-60, Mar-Apr 2001.

Pouchelon JL., Chetboul V., Devauchelle P., Delisle F., Mai W., Vial V.: Diagnosis of pulmonary thromboembolism in a cat using echocardiography and pulmonary scintigraphy Journal of Small Animal Practice 38(7): 306-10, Jul 1997.

Mai W.: Chapter 12 - Magnetic resonance imaging and computed tomography features of canine and feline spinal cord disease. Textbook of Veterinary Diagnostic Radiology, 6th edition, 847 pp. Page: 194-221, THRALL (eds.). Elsevier Saunders,St Louis,Missouri, 2013.