Penn Veterinary Medicine | University of Pennsylvania

Description of Clinical Expertise

Dr. Callan is a veterinary internist with clinical and research interests in hematology and transfusion medicine. She is interested in evaluation of patients with bleeding disorders, particularly platelet defects and heritable factor VII deficiency. Dr. Callan, in collaboration with Dr. Reid Groman (Section of Medicine) and Dr. Nicola Mason (Department of Pathobiology and Section of Medicine), has evaluated plateletpheresis as an option for producing a high quality canine platelet concentrate for transfusion. The same team is now interested in developing a therapeutic apheresis program at MJR-VHUP. In addition, Dr. Callan is investigating options for storage of canine platelet concentrate and issues associated with efficacy of platelet transfusions.

Selected Publications

Callan MB, Shofer FS, Catalfamo JL. : Effects of anticoagulant on pH, ionized calcium concentration, and agonist-induced platelet aggregation in canine platelet-rich plasma. Am J Vet Res 70: 472-477, 2009.

Appleman EH, Sachais BS, Patel R, Drobatz KJ, Groman RP, Kennedy DR, O’Donnell PA, Bryan C, Callan MB*. : Cryopreservation of canine platelets. J Vet Intern Med 23: 138-145, 2009.

Callan MB, Appleman EH, Shofer FS, Mason NJ, Brainard BM, Groman RP.: Clinical and clinicopathologic effects of plateletpheresis on healthy donor dogs. J Vet Intern Med 22: 776, 2008.

Appleman EH, Sachais BS, Patel R, Drobatz KJ, Groman RP, Kennedy D, O’Donnell P, Bryan C, Callan MB. : Evaluation of canine platelet cryopreservation methods. J Vet Intern Med 22: 777, 2008.

Callan MB, Appleman EH, Shofer FS, Mason NJ, Brainard BM, Groman RP. : Clinical and clinicopathologic effects of plateletpheresis on healthy donor dogs. Transfusion 48: 2214-2221, 2008.

Callan MB, Shofer FS, Catalfamo JL. : Effects of anticoagulant on pH, ionized calcium concentration, and platelet aggregation in canine platelet-rich plasma. J Vet Intern Med 22: 776, 2008.

Kaae JA, Callan MB, Brooks MB: Hereditary factor VII deficiency in the Alaskan Klee Kai dog. J Vet Intern Med Page: 976-981, 2007.

Brainard BM, Meredith CP, Callan MB, Budsberg SC, Shofer FS, Driessen B, Otto CM: Changes in platelet function, hemostasis, and prostaglandin expression in dogs treated with NSAIDs of varying cyclooxygenase selectivity Am J Vet Res Page: 251-257, 2007.

Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA: A novel missense mutation responsible for factor VII deficiency in research Beagle colonies J Thromb Haemost Page: 2616-2622, 2006.

Callan MB, Aljamali MN, Margaritis P, Seng A, Werner P, Griot-Wenk ME, High KA, Giger U: DNA screening for the Gly96Glu mutation causing factor VII deficiency in companion and research colony Beagles Vet Clin Pathol Page: S287, ACVCP, 2005.