Margaret M Sleeper

Associate Professor of Cardiology/Clinician Educator

Chief, Section of Cardiology

Contact Information
Section of Cardiology
Department of Clinical Studies
School of Veterinary Medicine
University of Pennsylvania
3900 Delancey Street
Philadelphia, PA 19104

Office: 215-898-6439
Email:
sleeper@vet.upenn.edu

Education

BS (English/Biology) Ursinus College, 1989

VMD University of Pennsylvania, School of Veterinary Medicine, 1993

Selected Publications

Bish LT, Sleeper, MM, Brainard B, Cole S, Russell N, Withnall E, Arndt J, Reynolds C, Davison E, Sammiquel J, Wu D, Gao G, Wilson JM, Sweeney HL: Percutaneous transendocardial delivery of self complementary adeno-associated virus serotype 6 (scAAV6)achieves efficient, global gene transfer to the canine heart superior to scAAV8, scVVA9 and single stranded AAV9 (ssAAV9). Molecular Therapy 2+: 1953-1959, 2008.

Sleeper MM, Fornasari B, Ellinwood NM , Weil MA, Melniczek J, O’Malley TM, Sammarco CD, Xu L, Ponder KP, and Haskins ME. : Gene therapy ameliorates cardiovascular disease in dogs with mucopolysaccharidosis VII Circulation 110: 815-820, 2004.

Ponder KP, Melniczek JR, Xu L, Weil MA, O'Malley TM, O'Donnell PA, Knox VW, Aguirre GD, Mazrier H, Ellinwood NM, Sleeper M, Maguire AM, Volk S, Mango RL, Zweigle J, Wolfe JH, Haskins ME.: Marked clinical improvements in mucopolysaccharidosis VII dogs after neonatal administration of a retroviral vector expressing ß-glucuronidase Proceedings of the National Academy of Science 99: 13102-13107, 2002.

Dambach D, Lannon A, Sleeper M, Buchanan J. : Familial dilated cardiomyopathy of young Portuguese water dogs Journal of Veterinary Internal Medicine 13: 65-71, 1999.

Sleeper M. : Juvenile dilated cardiomyopathy in Portuguese water dogs University of Pennsylvania Research Retreat 2001.

Sleeper MM, Haskins ME, Ponder KP: Gene therapy for cardiovascular manifestations of lysosomal storage diseases. Heart and metabolism: Genetic diseases of the heart III 41: 21-24, 2008.

Werner P, Raducha MG, Prociuk U, Sleeper MM, Henthorn PS.: A novel locus for dilated cardiomyopathy maps to canine chromosome 8 Genomics 91: 517-521, 2008.

Sleeper MM, Bissett S, Craig L. : Canine trichinosis presenting with high grade second degree AV block Journal of Veterinary Internal Medicine 20: 1228-1231, 2006.

Bish LT, Morine K, Sleeper MM, Sammiquel J, Wu D, Gao G, Wilson JM, Sweeney HL: AAV9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7 and AAV8 in the mouse and rat. Human Gene Therapy 19: 1359-1368, 2008.

Sleeper MM, Doan CJ, Langner P, Curtin S, Avila K, Lee DR. : Successful treatment of idiopathic dilated cardiomyopathy in an adult chimpanzee Comparative Medicine 55: 80-84, 2005.
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