Penn Veterinary Medicine | University of Pennsylvania

Description of Research Expertise

Paratuberculosis (Johne's Disease)
-Diagnosis
-Immune Response
-Experimental Infection Models
-Vaccination

Pharmacokinetics of antimicrobial drugs

Description of Clinical Expertise

Large Animal Internal Medicine

Selected Publications

Fecteau ME, Whitlock RH, Fyock TL, McAdams SC, Boston RC, Sweeney RW: Antimicrobial activity of gallium nitrate against Mycobacterium avium subsp. paratuberculosis in neonatal calves J Vet Int Med 25: 1152-1155, 2011.

Sweeney RW, Whitlock RH, Bowersock TL, Cleary DL, Meinert TR, Habecker PL, Pruitt GW: Effect of subcutaneous administration of a killed Mycobacterium avium subsp. paratuberculosis vaccine on colonization of tissues following oral exposure to the organism in calves. Am J Vet Res 70: 493-498, 2009.

Sweeney RW., Uzonna J., Whitlock RH., Habecker PL., Chilton P., Scott P.: Tissue predilection sites and effect of dose on Mycobacterium avium subs. paratuberculosis organism recovery in a short-term bovine experimental oral infection model Research in Veterinary Science 80(3): 253-9, Jun 2006.

Uzonna JE., Chilton P., Whitlock RH., Habecker PL., Scott P., Sweeney RW.: Efficacy of commercial and field-strain Mycobacterium paratuberculosis vaccinations with recombinant IL-12 in a bovine experimental infection model Vaccine 21(23): 3101-9, Jul 4 2003.

Sweeney RW, Whitlock RH, McAdams S: Comparison of three DNA preparation methods for real-time PCR confirmation of Mycobacterium avium subsp. paratuberculosis growth in an automated broth culture system Journal Veterinary Diagnostic Investigation 18: 587-590, 2006.

Sweeney RW., Jones DE., Habecker P., Scott P.: Interferon-gamma and interleukin 4 gene expression in cows infected with Mycobacterium paratuberculosis American Journal of Veterinary Research 59(7): 842-7, Jul 1998.

Sweeney RW., Whitlock RH., Rosenberger AE.: Mycobacterium paratuberculosis cultured from milk and supramammary lymph nodes of infected asymptomatic cows Journal of Clinical Microbiology 30(1): 166-71, Jan 1992.

Sweeney RW.: Tolerance of a rice-based oral rehydration solution given to normal calves Journal of Veterinary Internal Medicine 14(4): 463-7, Jul-Aug 2000.

Sielman ES., Sweeney RW., Whitlock RH., Reams RY.: Hypokalemia syndrome in dairy cows: 10 cases (1992-1996) Journal of the American Veterinary Medical Association 210(2): 240-3, Jan 15 1997.

Sweeney RW., Whitlock RH., Buckley CL., Spencer P., Rosenberger AE., Hutchinson LJ.: Diagnosis of paratuberculosis in dairy cattle, using enzyme-linked immunosorbent assay for detection of antibodies against Mycobacterium paratuberculosis in milk American Journal of Veterinary Research 55(7): 905-9, Jul 1994.

Ross J, Dallap BL, Dolente BA, Sweeney RW: Pharmacokinetics and pharmacodynamics of epsilon-aminocaproic acid in horses American Journal of Veterinary Research 68: 1016-1021, 2007.

Johnson AL, Burton AJ, Sweeney RW: Utility of two immunological tests for antemortem diagnosis of equine protozoal encephalomyelitis (Sarcocystis neurona infection) in naturally occurring cases. J Veterinary Internal Medicine 24: 1184-1189, 2010.