Penn Veterinary Medicine | University of Pennsylvania

Description of Research Expertise

Oncologic pathology with a particular interest in lymphoma and employing the World Health Organization classification system for lymphoid neoplasms in domestic animals. One goal of the research is to identify certain subtypes of lymphomas and correlate these subtypes to clinical behavior and optimal treatment protocols. We also hope to gain more insight into these diseases in humans, using the dog as a spontaneous large animal model.

Description of Clinical Expertise

Clinical diagnostics on our surgical biopsy service with an interest in lymphoid neoplasms and ophthalmic pathology as well as participation in our autopsy service.

Selected Publications

A. C. Durham, C. A. Pillitteri, M. San Myint, V. E. Valli: 203 cases of equine lymphoma classified according to the world health organization (WHO) classification criteria Veterinary Pathology 2012.

K. E. Flood-Knapik, A. C. Durham,T. P. Gregor, M. D. Sánchez, M. E. Durney, K. U. Sorenmo: Clinical, histopathological and immunohistochemical characterization of canine indolent lymphoma Veterinary and Comparative Oncology 2012.

Elizabeth L. Buza, Robert A. Menzies, Michael H. Goldschmidt, Amy C. Durham: Malignant peripheral nerve sheath tumor in a cat with nodal and pulmonary metastases Journal of Veterinary Diagnostic Investigation 2012.

Amanda L. Maas, Shirron L. Carter, E. Paul Wileyto, Joann Miller, Min Yuan, Guoqiang Yu, Amy C. Durham, Theresa M. Busch.: Tumor Vascular Microenvironment Determines Responsiveness to Photodynamic Therapy Cancer Research 72(8): 1-10, 2012.

AC Haley, SR Platt, M Kent, SJ Schatzberg, A Durham, S Cochrane, D Westworth, GD Shelton: Breed specific polymyositis in the Hungarian vizsla dog. Journal of Veterinary Internal Medicine 25(2) 2011.

Grossman CE, Pickup S, Durham A, Wileyto EP, Putt ME, Busch TM: Photodynamic therapy of disseminated non-small cell lung carcinoma in a murine model. Lasers Surg Med 43(7): 663-75, 2011.

Smita S Matkar, Amy Durham, Angela Brice, Timothy C Wang, Anil K. Rustgi, Xianxin Hua. : Systemic activation of K-ras rapidly induces gastric hyperplasia and metaplasia in mice American Journal of Cancer Research 1(4): 432-445, 2011.

Jantra Ngosuwan Suran, Amy Durham, Wilfried Mai, Gabriela Seiler: Contrast enhancement of extradural compressive material on magnetic resonance imaging Veterinary Radiology & Ultrasound 52(1): 10-16, 2011.

V.E. Valli, M. San Myint, A. Barthel, D. Bienzle, J. Caswell,F. Colbatzky, A. Durham, E.Ehrhart, Y. Johnson, C. Jones, M.Kiupel, P. LaBelle, S. Lester, M. Miller, P. Moore, S.Moroff, P. Roccabianca, J. Ramos-Vara, A. Ross, T. Scase, H.,Tvedten, W. Vernau: World Health Organization Classification of Canine Malignant Lymphomas: Report of the Lymphoma Committee of the American College of Veterinary Pathologists Oncology Initiative Veterinary Pathology Vol 48 : 198-211, 2011.

Eugenia Pacheco-Pinedo, Amy Durham, Kathleen Stewart, Ashley Goss, Min Min Lu, Francesco DeMayo, Edward Morrisey: Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. Journal of Clinical Investigation 121(5): 1935-1945, 2011.