Penn Veterinary Medicine | University of Pennsylvania

Description of Research Expertise

Cardiac biomarkers (troponin, natriuretic peptides [BNP, ANP])
Acquired mitral valve disease (myxomatous degeneration)
Cardiomyopathy (canine dilated cardiomyopathy)
Clinical trials
Serotonin signaling and valve disease
Calstabin2 (FKBP12.6) and ryanodine receptors in cardiomyopathy
Animal models of heart disease and heart failure
Quality of life issues in dogs and cats with heart disease

Description of Clinical Expertise

Canine and feline models of heart disease
Acquired mitral valve disease (myxomatous degeneration)
Canine dilated cardiomyopathy

Selected Publications

Oyama MA. : Management of Specific Cardiac Diseases Feline Emergency and Critical Care Medicine. Costello MF, Drobatz KJ, eds. (eds.). Blackwell Publishing, Ames, IA, 2009 - in press.

Kellihan, Heidi B. Oyama, Mark A. Reynolds, Caryn A. Stepien, Rebecca L.: Weekly variability of plasma and serum NT-proBNP measurements in normal dogs. Journal of Veterinary Cardiology 11( Suppl 1): S93-7, May 2009.

Schmidt, M K. Reynolds, C A. Estrada, A H. Prosek, R. Maisenbacher, H W. Sleeper, M M. Oyama, M A.: Effect of azotemia on serum N-terminal proBNP concentration in dogs with normal cardiac function: a pilot study. Journal of Veterinary Cardiology 11( Suppl 1): S81-6, May 2009.

Fox, Philip R. Oyama, Mark A. Reynolds, Caryn. Rush, John E. DeFrancesco, Terri C. Keene, Bruce W. Atkins, Clark E. Macdonald, Kristin A. Schober, Karsten E. Bonagura, John D. Stepien, Rebecca L. Kellihan, Heidi B. Nguyenba, Thaibinh P. Lehmkuhl, Linda B. Lefbom, Bonnie K. Moise, N Sydney. Hogan, Daniel F.: Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats. Journal of Veterinary Cardiology 11( Suppl 1): S51-61, May 2009.

Arndt, Jason W. Oyama, Mark A.: Agitated saline contrast echocardiography to diagnose a congenital heart defect in a dog. Journal of Veterinary Cardiology 10(2): 129-32, Dec 2008.

Peddle, Gordon D. Boger, Lore. Van Winkle, Thomas J. Oyama, Mark A.: Gerbode type defect and third degree atrioventricular block in association with bacterial endocarditis in a dog. Journal of Veterinary Cardiology 10(2): 133-9, Dec 2008.

Oyama, Mark A.: Canine heart disease: progress and promise. Journal of Small Animal Practice 49(11): 549-50, Nov 2008.

Oyama, Mark A.: A QUEST begins.[comment]. Journal of Veterinary Internal Medicine 22(5): 1076-8, Sep-Oct 2008.

Oyama, Mark A. Rush, John E. O'Sullivan, M Lynne. Williams, Regan M. Rozanski, Elizabeth A. Petrie, Jean-Paul. Sleeper, Meg M. Brown, Dorothy Cimino.: Perceptions and priorities of owners of dogs with heart disease regarding quality versus quantity of life for their pets. Journal of the American Veterinary Medical Association 233(1): 104-8, Jul 1 2008.

Oyama, Mark A. Reiken, Steve. Lehnart, Stephan E. Chittur, Sridar V. Meurs, Kathryn M. Stern, Joshua. Marks, Andrew R.: Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency. Journal of Veterinary Cardiology 10(1): 1-10, Jun 2008.