Makoto Senoo

Assistant Professor of Developmental Biology

Contact Information
Institute for Regenerative Medicine
Department of Animal Biology
University of Pennsylvania Veterinary School
3800 Spruce St., Room 153E Old Vet.
Philadelphia, PA 19104

Office: 215-746-2062
Fax: 215-573-5188

Email:
msenoo@vet.upenn.edu

Education

BS (Applied Chemistry) Keio University, 1992

MS (Biomedical Engineering) Keio University Graduate School, 1994

PhD (Medicine) Tokai University School of Medicine, 2002

Description of Research Expertise

KEY WORDS:
Stem Cells; Tissue Regeneration; Animal Models

RESEARCH INTERESTS:
Stem Cell Biology; Regenerative Medicine

RESEARCH FIELDS:
Molecular Biology; Cell Biology; Oncology, Mouse Genetics

Selected Publications

Suzuki, D. and Senoo, M.: Increased p63 phosphorylation marks early transition of epidermal stem cells to progenitors. Journal of Investigative Dermatology in press, advance online publication 24 May 2012.

Carter, R.A. Engiles, J.B. Megee, S.O. Senoo, M.* and Galantino-Homer, H.L.* (*co-corresponding authors): Decreased expression of p63, a regulator of epidermal stem cells, in the chronic laminitic equine hoof. Equine Veterinary Journal 43: 543-551, 2011.

Senoo, M., Pinto, F., Crum, C. P. and McKeon, F. : p63 is essential for the proliferative potential of stem cells in stratified epithelia. Cell 129: 523-536, 2007.

Ueki, Y., Lin, C.Y., Senoo, M., Ebihara, T., Agata, N., Onji, M., Saheki, Y., Kawai, T., Mukherjee, P. M., Reichenberger, E. and Olsen, B. R: Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell 128: 71-83, 2007.

Senoo, M., Manis, J. P., Alt, F. W. and McKeon, F. : p63 and p73 are not required for the development and p53-dependent apoptosis of T cells. Cancer Cell 6: 85-89, 2004.
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