Molecule That Restricts Mouse Cells' Potency Could Yield Embryonic Stem Cells Without the Sacrifice of Embryos
Wednesday, January 03, 2001
PHILADELPHIA - Scientists at the University of Pennsylvania have identified a receptor that plays a key role in restricting embryonic stem cellspluripotency, their ability to develop into virtually any of an adult animal cell types. The work is the first demonstration of a mechanism by which pluripotency is lost in mammalian embryos, one that operates with nearly the precision of an on/off switch in mouse embryos.
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Penn's School of Veterinary Medicine is one of the world's premier veterinary schools. Founded in 1884, the School was built on the concept of Many Species, One Medicine™. The birthplace of veterinary specialties, the School serves a distinctly diverse array of animal patients, from pets to horses to farm animals at our two campuses. In Philadelphia, on Penn's campus, are the Matthew J. Ryan Veterinary Hospital for companion animals, as well as classrooms, laboratories and the School's administrative offices. The large-animal facility, New Bolton Center, in Kennett Square, Pa., encompasses hospital facilities for the care of horses and food animals as well as diagnostic laboratories serving the agriculture industry. The School has successfully integrated scholarship and scientific discovery with all aspects of veterinary medical education.
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