Penn Veterinary Researchers Identify a Critical Growth Factor That Stimulates Sperm Stem Cells to Thrive
Friday, March 06, 2009
Researchers at the University of Pennsylvania School of Veterinary Medicine and Pennsylvania State University have identified for the first time a specific “niche factor” in the mouse testes called colony stimulating factor 1, Csf1, that has a direct effect on sperm stem cell self-renewal. Moreover, the study shows that the origin of this growth factor is the Leydig cell — located in the testes and stimulated by the pituitary gland to supply testosterone — that secretes Csf1 and enhances self-renewal of the stem cells.
Penn's School of Veterinary Medicine is one of the world's premier veterinary schools. Founded in 1884, the School was built on the concept of Many Species, One Medicine. The birthplace of veterinary specialties, the School serves a distinctly diverse array of animal patients, from pets to horses to farm animals at our two campuses. In Philadelphia, on Penn's campus, are the Matthew J. Ryan Veterinary Hospital for companion animals, as well as classrooms, laboratories and the School's administrative offices. The large-animal facility, New Bolton Center, in Kennett Square, Pa., encompasses hospital facilities for the care of horses and food animals as well as diagnostic laboratories serving the agriculture industry. The School has successfully integrated scholarship and scientific discovery with all aspects of veterinary medical education.
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