Cytokine Signal Shuts Down Hyperactive T Cells; “Off Switch” Could Halt Inflammation And Autoimmunity
Tuesday, November 25, 2003
PHILADELPHIA -- Since their discovery, cytokines have provided biomedical researchers with a tangled web of immune-system pathways to unknot. While most known cytokines have a role in stimulating immunity, one cytokine, IL-27, may actually suppress CD4 T cells, the helper T cells that orchestrate the immune system response to infections, according to researchers at the University of Pennsylvania School of Veterinary Medicine.
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