Cytokine Signal Shuts Down Hyperactive T Cells; “Off Switch” Could Halt Inflammation And Autoimmunity
Tuesday, November 25, 2003
PHILADELPHIA -- Since their discovery, cytokines have provided biomedical researchers with a tangled web of immune-system pathways to unknot. While most known cytokines have a role in stimulating immunity, one cytokine, IL-27, may actually suppress CD4 T cells, the helper T cells that orchestrate the immune system response to infections, according to researchers at the University of Pennsylvania School of Veterinary Medicine.
Penn's School of Veterinary Medicine is one of the world's premier veterinary schools. Founded in 1884, the School was built on the concept of Many Species, One Medicine. The birthplace of veterinary specialties, the School serves a distinctly diverse array of animal patients, from pets to horses to farm animals at our two campuses. In Philadelphia, on Penn's campus, are the Matthew J. Ryan Veterinary Hospital for companion animals, as well as classrooms, laboratories and the School's administrative offices. The large-animal facility, New Bolton Center, in Kennett Square, Pa., encompasses hospital facilities for the care of horses and food animals as well as diagnostic laboratories serving the agriculture industry. The School has successfully integrated scholarship and scientific discovery with all aspects of veterinary medical education.
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