Funded Projects - 2008
Student: Rachel Baek
Title of Project: Functional Immunology of Hematopoietic Embryonic Stem Cells
Mentor: John McLaughlin
Department: Animal Biology, Veterinary Medicine
Student: Caroline Cantner
Title of Project: Molecular Characterization of Ichthyosis in the American Bulldog
Mentor: Margaret Casal
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Denise Chang
Title of Project: Evaluation of Novel Alloantibody and Autoantibody Diagnostics to Predict Blood Incompatibilities Prior to and Post Transfusion in Dogs
Mentor: Urs Giger
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Ann Elizabeth Cooper
Title of Project: Mapping of Cone Photoreceptors in the Canine Retina
Mentor: Andras Komaromy
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Heather Fowler
Title of Project: The Effect of Global Warming on the Distribution of Plasmodium relictum in the Hawiian Islands
Mentor: Gary Smith
Department: Clinical Studies, New Botlon Center, Veterinary Medicine
Student: Jessica Fragola
Title of Project: Characteristics of Membrane Fusion of Crimean-Congo Hemorrhagic Fever Virus via Gn and Gc Glycoproteins
Mentor: Robert Doms
Department: Microbiology, School of Medicine
Student: Jennifer Frohlich
Title of Project: Demonstration of an Oct4-Granulin Signaling Axis Regulating Trophoblast Stem Cells
Mentor: George Gerton
Department: OB/GYN, School of Medicine
Student: Maureen Carolyn Gates
Title of Project: The Influence of Prophylactic Medications on Endoparasite Prevalence in Companion Animals: A Time Series Analysis of Cases from a Veterinary Teaching Hospital Between 1984 and 2007
Mentor: Tom Nolan
Department: Pathobiology, Veterinary Medicine
Student: Moira Kelleher
Title of Project: Characterization of NF-κB Activity and the Effects of Its Inhibition by NEMO Binding Domain Peptide in Canine Cancer Cells
Mentor: Nicola Mason
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Alexander Koenigstein
Title of Project: Mechanism of Mitochondrial Respiratory Stress Induced Osteoclast Differentiation
Mentor: Narayan Avadhani
Department: Animal Biology, Veterinary Medicine
Student: Melissa Lewis
Title of Project: Pathotropic Migration of Endogenous Neural Progenitor Cells
Mentor: Charles Vite
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Amanda McCullough
Title of Project: Analysis of the Effects of Lead and/or Mercury Toxicity in Avian Species
Mentor: Lisa Murphy
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Alexandra O’Keefe
Title of Project: Characterization of Antimicrobial Resistance Genes from Canine and Feline E. coli Isolates Associated with Urinary Tract Infections
Mentor: Dieter Schifferli
Department: Pathobiology, Veterinary Medicine
Student: Bradley Rosato
Title of Project: Canine Myocardial Oxidative Stress Under Normal, Anesthetized and Cardiomyopathic Conditions
Mentor: Meg Sleeper and Narayan Avadhania
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Carrie Lynn Santare
Title of Project: Volumetric Carbon Dioxide to Determine the Efficacy of Chest Compressions During Cardiopulmonary Resuscitation
Mentor: Manuel Boller
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Carolyn Santore
Title of Project: Determining the Effects of Selective Inhibition of NF-κB Signaling on Atherosclerosis In Vivo
Mentor: Michael May
Department: Animal Biology, Veterinary Medicine
Student: Erin Scott
Title of Project: Characterization of Photoreceptor Loss and Inner Retinal Remodeling in a Canine Model of Cone-Rod Dystrophy
Mentor: William Beltran
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Abigail Shearin
Title of Project: Molecular Basis of Canine Cystinuria
Mentor: Paula Henthorn
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Kelly Slattery
Title of Project: Evaluation and Validation of a Method for Microcirculatory Image in a Porcine Cardiac Arrest Model
Mentor: Manuel Boller
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: David Vafek
Title of Project: Cause of Death in Myocytes Due to Exposure to Hypoxic Conditions
Mentor: Cindy Otto
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Cory Waxman
Title of Project: In Vitro Maturation of Canine, Feline, Ovine and Human Ovarian Follicles
Mentor: Christos Coutifaris
Department: OB/GYN, School of Medicine
Student: Ashley Yanchik
Title of Project: Meiotic Rescue of β-Thalassemia
Mentor: John McLaughlin
Department: Animal Biology, Veterinary Medicine
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Funded Projects - 2007
Student: Aimee Colbath
Title of Project: Geographic Risk Factors for Escherichia coli Infection in Cattle in Pennsylvania and New York State
Mentor: Gary Smith
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Heather Fowler
Title of Project: Characterization of Novel Type 1 and II Transforming Growth Factor-Beta Receptors in Schistosoma mansoni
Mentor: Ed Pearce
Department: Pathobiology, Veterinary Medicine
Student: Maureen Gates
Title of Project: Analyzing the Spread of West Nile Virus Through Mosquito Vectors: A Meta-Analysis
Mentor: Raymond Boston
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Randi Gold
Title of Project: Pathophysiology of Canine Hip Dysplasia: Does Capsular Fibrosis Serve as Biological Compensation for Hip Laxity and Osteoarthritis
Mentor: Gail Smith
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Michael Jennings
Title of Project: Optimization and Clinical Implementation of Stem Cell-Seeded Nanofiber-Based Tissue Engineered Constructs for Meniscus Repair
Mentor: Robert Mauck
Department: Orthopaedic Surgery, Medicine
Student: Melissa Lewis
Title of Project: Characterization of Cerebrocortical Dysfunction in Feline Niemann-Pick Type C (NPC) Disease
Mentor: Charles Vite
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Peter Midgley
Title of Project: A Mathematical Model for the Transmission Dynamics and Control of Canine Distemper Virus (CDV) Infection in Wild Ethiopian Wolves (Canis simensis)
Mentor: Gary Smith
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Jamie Minnella
Title of Project: Development and Assessment of a Real-Time PCR Assay for Rapid Detection of Salmonella in Clinical Diagnostic Laboratory Settings
Mentor: Shelley Rankin
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Michelle Nelson
Title of Project: Yersinia pestis Virulence Protein Purification and Experimental Mutant Production
Mentor: Dieter Schifferli
Department: Pathobiology, Veterinary Medicine
Student: Brianne O'Loughlin
Title of Project: Cross Species Comparison of Congenital Heart Defects Involving the Genes Edg2 and MAPK1
Mentor: Sulagna Saitta
Department: Pediatrics, Medicine
Student: Laura Pell
Title of Project: Generation of Canine Single Chain Fragment Variable Antibody Libraries for the Identification and Targeting of Tumor-Associated Antigens in the Dog
Mentor: Nicola Mason
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Miriam Sadek
Title of Project: Mitochondrial Respiratory Stress Induced Tumor Invasion Through Activation of a Novel NFκB Pathway
Mentor: Narayan Avadhani
Department: Animal Biology, Veterinary Medicine
Student: Abigail Shearin
Title of Project: Cystinuria in Dogs
Mentor: Paula Henthorn
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Marissa Sue
Title of Project: Positive Serodiagnosis for Toxoplasma gondii and Leptospira spp. And its Correlation to Serum Biochemical Parameters in Medium and Large Carnivores of Emas National Park, Brazil
Mentor: Karen Rosenthal
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Nancy Hyun Joo Sung
Title of Project: Identification of Correlations Between Canine Behavioral Traits and Specific Health Problems
Mentor: James Serpell
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Samuel Tucker
Title of Project: Innervation of the Canine Intervertebral Disc: An Immunohistochemical Study
Mentor: Thomas Schaer
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Melissa Vetter
Title of Project: L1 Retrotransportation in a Transgenic Rat Model
Mentor: Haig Kazazian
Department: Genetics, Medicine
Student: Andrea Weissman
Title of Project: A Time Interval Study of the Effect of Intermittent Hypoxia on Nitrate and Nitrite Concentrations in Drosophila melanogaster
Mentor: Cindy Otto
Department: Clinical Studies, Philadelphia, Veterinary Medicine
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Funded Projects - 2006
Student: Lisa Berman
Title of Project: Characterization of the Role of Intestinal Epithelial Cells in the Regulation of CD4+T Helper Cell Responses Following Gut Nematode Infection.
Mentor: David Artis
Department: Pathobiology, Veterinary Medicine
Student: Megan Brace
Title of Project: Multi-Drug Resistant Slmonella Newport in Equine Colic Patients: Can Outcomes and Cluster Analysis Aid in the Development of Better Infection Control and Therapeutic Strategies.
Mentor: Helen Aceto
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Cara Catanese
Title of Project: Studies on Binding and Invasive Properties of Yersinia pestis Autotransporters.
Mentor: Dieter Schifferli
Department: Pathobiology, Veterinary Medicine
Student: Jennifer Dietz
Title of Project: Longevity of Motility of Spermand Bacteria Present in Equine Semen Stored in Semen Extender Containing Pipercillin.
Mentor: Patricia Sertich, Charles Benson
Department: Clinical Studies, New Bolton Center, Veterinary Medicine and Pathobiology, Veterinary Medicine
Student: Carrie Ellis
Title of Project: Expression and Identification of Yersinia pestis Surface Proteins for Future Vaccine Development Against Plague
Mentor: Dieter Schifferli
Department: Pathobiology, Veterinary Medicine
Student: Jennie Kim
Title of Project: The Effects of L-NAME and Hypoxia on Drosophila Melanogaster.
Mentor: Cindy Otto
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Melissa King
Title of Project: An Analysis of the Oral Rabies Vaccination (ORV) Program in New York State.
Mentor: Gary Smith
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Diana Knight
Title of Project: Assessing the Effects of Cued Fear Conditioning and the Role of the Amygdala in REM Sleep Patterns of Male S-D Rats.
Mentor: Adrian Morrison
Department: Animal Biology, Veterinary Medicine
Student: Catherine Kusiak
Title of Project: Lysosomal Storage Diseases: An Evaluation of Cardiovascular Function.
Mentor: Meg Sleeper, Mark Haskins
Department: Pathobiology, Veterinary Medicine
Student: Simon Long
Title of Project: The Functional Role of the Membrane Glycoprotein and Small Envelope Protein in the Mouse Hepatitis Virus.
Mentor: Susan Weiss
Department: Microbiology, Medicine
Student: Katherine McKeown
Title of Project: Utilizing cDNA Subtraction to Examine the Effects of MacroH2A Deletion in a Colony of Knockout Mice.
Mentor: John Pehrson
Department: Animal Biology, Veterinary Medicine
Student: Catherine Morrow
Title of Project: Factor XI Deficiency in Kerry Blue Terriers: Frequency and Impact of SINE Insertion.
Mentor: Urs Giger
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Diana Niculescu
Title of Project: Gene Expression in Cone Photoreceptors of Normal Dogs with Achromatopsia.
Mentor: Andras Komaromy
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Sharon Parker
Title of Project: Meloxicam Use in Avian Rehabilitation: Dosage Requirements and Efficacy, as Compared to Aspirin and Butorphanol.
Mentor: Erica Miller, Lisa Murphy
Department: Clinical Studies, Philadelphia, Veterinary Medicine, and Pathobiology, Veterinary Medicine
Student: Maria Raymond
Title of Project: Effects of Co-Engagement of Toll-Like Receptors (TLRs) and Complement Receptors.
Mentor: Oriol Sunyer
Department: Pathobiology, Veterinary Medicine
Student: Michael Reese
Title of Project: Assessment of Cryocapacitation and Its Relation to Fertility of Frozen Bovine Sperm.
Mentor: Ina Dobrinski
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Brigid Reilly
Title of Project: Use of a Novel Yeast Two-Hybrid System to Identify Homotypic and Heterotypic Interactions of Herpes Simplex Virus Glycoproteins.
Mentor: Roselyn Eisenberg, Gary Cohen
Department: Pathobiology, Veterinary Medicine
Student:
Title of Project: Cell fate of Notochordal Cells During Late Embryonic and Postnatal Life in Rodent Model.
Mentor: Tom Schaer
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Miriam Sadek
Title of Project: Role of Mitochondrial Stress Signaling in the Pancreatic Tumor Invasion.
Mentor: Narayan Avadhani, Gopa Biswas
Department: Animal Biology, Veterinary Medicine
Student: Lindsay Thalheim
Title of Project: Transcriptional Regulation of the Intra-S-Phase Regulator of CDC7 in Human Myeloid Leukemic Cells: A New Downstream Target of the C-Myb Protooncogene.
Mentor: Alan Gewirtz
Department: Hematology-Oncology, Medicine
Student: Amanda Theodore
Title of Project: The Role of Regulatory T Cell Function in Leishmania mexicana Infection.
Mentor: Phil Scott
Department: Pathobiology, Veterinary Medicine
Student: Rachel Toaff-Rosenstein
Title of Project: Evaluation of the Insulin Gene and DLA-DRB2 Alleles as Genetic Markers for Diabetes Mellitus in Samoyed and Australian Terrier Dogs.
Mentor: Rebecka Hess, Paula Henthorn
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Angharad Knight Waite
Title of Project: Molecular Cloning of Canine OX40L and Functional Evaluation of its Co-Stimulatory Effects on Canine T Cell Subsets.
Mentor: Nicola Mason
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Connie Yeh
Title of Project: Functional Study of the Insulin Receptor Kinase IRK-1 from Strongyloides stercoralis Using Caenorhabditis elegans as a Genetic Surrogate.
Mentor: James Lok
Department: Pathobiology, Veterinary Medicine
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Funded Projects - 2005
Student: Donniel Astor
Title of Project: Induction of the Unfolded Protein Response in Flies with Long-Term Intermittent Hypoxia
Mentor: Cindy Otto
Department: Clinical Studies, Philadelphia , Veterinary Medicine
Student: Lisa Berman
Title of Project: Characterization of the Novel Canine and Feline Erythrocyte Antigens Dal and Mik
Mentor: Urs Giger
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Megan Brace
Title of Project: A Mathematical Model for the Transmission Dynamics and Control of Hepatitis B Virus Infection in Wild Chimpanzees (Pan Troglodytes)
Mentor: Gary Smith
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Amy Brazil
Title of Project: Impact of Stress and Dietary High Fat on Learning and Memory
Mentor: Tracy Bale
Department: Animal Biology, Veterinary Medicine
Student: Janik Gasiorowski
Title of Project: Electrotransfer of Plasmid DNA in the Equine Flexor Tendon
Mentor: Dean Richardson
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Kelly Giunta
Title of Project: Generation and Characterization of Equine Embryonic Stem Cell Lines
Mentor: John McLaughlin
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Ryan Gorman
Title of Project: Development of Real-Time 16S rRNA Gene Polymerase Chain Reaction Assay to Diagnose Septic Peritonitis
Mentor: Shelley Rankin
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Asal Homayouni
Title of Project: The Role of TSR Proteins in Myc-Overexpressed Cells of Mouse Colon Cancer
Mentor: Andrei Thomas-Tikhonenko
Department: Pathobiology, Veterinary Medicine
Student: Tyler Hotaling
Title of Project: Molecular Characterization of Staphylococcus aureus Strains from the University of Pennsylvania and the University of Delaware Heifers Before, During and After Co-Mingling
Mentor: Shelley Rankin, Charles Benson, Mike Kristula
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Ann Klocke
Title of Project: Molecular and Cellular Regulation of Boar Sperm Motility
Mentor: Regina Turner
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Jennifer Magilton
Title of Project: Effect of PaO2 Oscillations on the Correlation of Non-Invasive Measurements of SpO2 with Direct Measurements of PaO2 in Mechanically Ventilated Patients
Mentor: Rebecca Syring
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Isaac Maxmen
Title of Project: Identification and Typing of the Ehlers-Danlos Syndrome in the Canine Model
Mentor: Margaret Casal
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Emily Miedel
Title of Project: Role of Astrocytes in Resistance to Toxoplasic Encephalitis
Mentor: Chris Hunter
Department: Pathobiology, Veterinary Medicine
Student: Jennifer Scheidt
Title of Project: Characterization and Identification of the Disease-Causing Mutation of Lupoid Dermatosis in the German Shorthaired Pointer
Mentor: Margaret Casal
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Lindsay Thalheim
Title of Project: Myb Modulation of CDC7 Expression in Hematopoietic Cells
Mentor: Alan Gewirtz
Department: Medicine and Pathology, Medicine
Student: LeAndra Thompson
Title of Project: The Effects of Cytoplasmic Dynein Disruption on the De-Stabilization of the Mammalian Neuromuscular Junction
Mentor: Erika Holzbaur
Department: Physiology, Medicine
Student: Tracy Zeldis
Title of Project: Defining the Effects of Specific NEMO Mutations on Pro-Inflammatory NF-κB Activation
Mentor: Michael May
Department: Animal Biology, Veterinary Medicine
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Funded Projects - 2004
Student: Jeffrey Burdick
Title of Project: Reparative vs. Regenerative Tendon Healing in an Animal Model.
Mentor: Louis J. Soslowsky
Department: Bioengineering, School of Medicine
Student: Cynthia Clendenin
Title of Project: Identification of Genes Causing Lupoid Dermatosis in the German Shorthaired Pointer.
Mentors: Paula Henthorn, Margaret Casal
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Modesty Dallmeyer
Title of Project: Improving Sow Fertility Through Novel Semen Extender Components.
Mentor: Ina Dobrinski
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Eva Furrow
Title of Project: How Does Vincristine Cause Neuropathy in Normal and Mutant Mice?
Mentor: Christiane Massicotte
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Rachael Joseph
Title of Project: The Role of B-Cell Transcription Factors, EBF and Pax5, in the Spontaneous Transformation of B lymphoma Cells to Myeloid Cells In Vitro.
Mentor: Michael Atchison
Department: Animal Biology, Philadelphia, Veterinary Medicine
Student: Lyndsey Larson
Title of Project: Mitochondrial Targeting of Amyloid Protein in Feline Islet Amyloidosis.
Mentor: Narayan Avadhani
Department: Animal Biology, Philadelphia, Veterinary Medicine
Student: Maureen Luschini
Title of Project: Do Cats HarborBorrelia burgdorferi and Is Its Presence linked to Lyme Disease Pathology?
Mentor: Thomas Nolan
Department: Pathobiology, Philadelphia, Veterinary Medicine
Student: Grace Anne Mengel
Title of Project: Is There a Role for T-type Calcium Channels in Sperm Motility?
Mentor: Regina Turner
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Craig Meredith
Title of Project: Changes in Primary Hemostasis and Clot Formation in Dogs Treated with Cycooxygenase Inhibitors with Varying Isoenzyme Selectivity.
Mentors: Cynthia Otto, Beth Callan, Benjamin Brainard
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Catalina Montealagre
Title of Project: Vascular Endothelial Growth Factor Levels and Activity in Conjunction with Multifrequency Bioimpendance Analysis in Critically Ill Dogs.
Mentor: Cynthia Otto
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Heidi L. Reesnick
Title of Project: Detection of Recombinant Human Erythropoietin (rhEPO) and Analysis of Performance Indices Following rhEPO Administration in Racehorses.
Mentor: Eric Birks
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Scott Roberts
Title of Project: Identification of Leukocidin Genes in Stphylococcus schleiferi Subspecies coagulans by Real-Time Polymerase Chain Reaction.
Mentor: Shelley Rankin
Department: Pathobiology, New Bolton Center, Veterinary Medicine
Student: Sara Rybolt
Title of Project: Pharmacokinetic Study of Non-Steroidal Anti-Inflammatory Drugs in Rehabilitation Birds.
Mentor: Robert Poppenga
Department: Pathobiology, New Bolton Center, Veterinary Medicine
Student: Heather Simon
Title of Project: The In Vitro Effects of Shape on Elution Characteristics from Gentamicin-Impregnated PMMA.
Mentors: Amy Kapatkin, Karen Rosenthal, Avery Bennett, Robert Poppenga Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Rebecca Spivack
Title of Project: Effects of Cyclical Lung recruitment and Pa O2 Oscillations on Multiple Organ Dysfunction.
Mentors: Rebecca Syring, Cynthia Otto
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Kirsten Steele
Title of Project: Mechanisms of the Anti-Tumor Effect of Tumor Necrosis Factor (TNF) in Pre-Clinical Models.
Mentor: Douglas Fraker
Department: Surgical Oncology, School of Medicine
Student: Heather Wall
Title of Project: Modafinil and msrA Expression in Drosophila.
Mentor: Joan Hendricks
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Koranda Wallace
Title of Project: Immunohistochemical Investigation of Laminin 5 and Other Basement Membrane Zone Proteins in a Litter of Labrador Retrievers with Inherited Epidermolysis Bullosa.
Mentor: Margaret Casal
Department: Clinical Studies, Philadelphia, Veterinary Medicine
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Funded Projects - 2003
Student: Greg Arbitter
Title of Project: Kinetic Gait Analysis of Healthy Dogs on Various Surfaces.
Mentor: Amy Kapatkin
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Jennifer Ascano
Title of Project: A Direct Interaction Between Dynein Intermediate Chain and Neurofilament subunits M and L May Mediate Retrograde Trafficking of Neurofilaments.
Mentor: Erika Holzbaur
Department: Physiology, School of Medicine
Student: Jessica Bertout
Title of Project: Steroid Regulation of EMP2 Localization and Expression in Human Endometrial Cells.
Mentor: Carmen Williams
Department: OB/GYN
Student: Alexandre Daley
Title of Project: Anchoring of CA 2+ Signaling Pathway in the Sperm Flagellum.
Mentor: Regina Turner
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Keira Geithman
Title of Project: Canine Parvovirus: A Case-Control Study on Factors Influencing Disease Incidence.
Mentor: Gary Smith
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Jennifer Kim
Title of Project: Drug Metabolism by Recominant Cytochrome P450 2D6
Mentor: Narayan Avadhani, Gary Smith
Department: Animal Biology, Veterinary Medicine
Student: Maureen Luschini
Title of Project: Prevalence of Ehrlichia canis, Anaplasma phagocytophila, and Bartonella spp. In Dogs Determined by PCR and Serology.
Mentor: Shelley Rankin
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Kari Lyon
Title of Project: Gait Analysis in Dynamitin Mice: Correlation with Early Axonal Transport Defects.
Mentor: Erika Holzbaur
Department: Physiology, School of Medicine
Student: Xuan Pan
Title of Project: Temporal Requirements of YY1 Expression for PcG-Dependent Transcriptional Repression.
Mentor: Michael Atchison
Department: Animal Biology, Veterinary Medicine
Student: Lora Perl
Title of Project: Comparison of Mouse and Cat Oct4.
Mentor: Hans Scholer
Department: Animal Biology, New Bolton Center, Veterinary Medicine
Student: Zoe Ramagnano
Title of Project: An In Vitro Study on the Role of CD46 in the Differentiation and Propagation of Murine Tr1 Cells.
Mentor: Philip Scott and Oriol Sunyer
Department: Pathobiology, Veterinary Medicine
Student: Ellen Rickey
Title of Project: Strain Characteristics of the Equine Cruciate Ligaments.
Mentor: David Nunamaker
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Jennifer Stevens
Title of Project: Development of a Rapid Dot Blot Immunoassay for the Detection of Salmonella enterica Serotype Newport.
Mentor: Helen Aceto and Shelley Rankin
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Alanna Toll
Title of Project: Lymphocyte/Enterocyte Interactions in Canine Inflammatory Bowel Disease.
Mentor: Robert Washabau
Department: Clinical Studies, Philadelphia, Veterinary Medicine
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Funded Projects - 2002
Student: Beth Appleman
Title of Project: Characterization of the Altered Glycosaminoglycans and Proteoglycans in Collagen X Transgenic and Null Mice.
Mentor: Olena Jacenko
Department: Animal Biology, Veterinary Medicine
Student: Diana Chang
Title of Project: Regulation of Glut3, a Glucose Transporter, During Sperm Capacitation and Germ Cell Development
Mentor: George Gerton
Department: OB/GYN
Student: Rachel Cianciolo
Title of Project: Dynamics of Membrane Rafts During Sperm Capacitation.
Mentor: Carmen Williams
Department: OB/GYN
Student: Daniel Clayton
Title of Project: Mechanisms of Immunopathology in Canine Inflammatory Bowel Disease.
Mentor: Robert Washabau
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Kathy Heym
Title of Project: Expression Optimization of a Fish DNA Vaccine against Infectious Hematopoietic Necrosis Virus
Mentor: Oriol Sunyer
Department: Pathobiology, Veterinary Medicine
Student: Melissa Java
Title of Project: The Effects of pO 2 Oscillations on the Production of Cytokines.
Mentor: Cindy Otto
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Kimberly Kovath
Title of Project: The Effects of Intermittent Hypoxia on Coagulation and Inflammatory Mediators in Mice.
Mentor: Sigrid Veasey
Department: Neurosciences, School of Medicine
Student: Rebecca Linke
Title of Project: Demonstration of Functional Competence in Pig Sperm from Testis Xenographs.
Mentor: Ina Dobrinski
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Jennifer Luff
Title of Project: The Spatial Dynamics of West Nile Virus Infection in Birds in the USA.
Mentor: Gary Smith
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Lauren May
Title of Project: Role of Mitochondrial Stress Signaling in Tumor Progression and Invasion.
Mentor: Narayan Avadhani, Gary Smith
Department: Animal Biology, Veterinary Medicine
Student: James Rhodes
Title of Project: Sequence Generation and Analysis of Canine ED1 and NEMO: Two Suspect Genes in Canine X-linked Hypohidrotic Ectodermal Dysplasia.
Mentor: Margaret Casal
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: John Rossi
Title of Project: The Role of Platelets in Circulating Tumor Cell Survival and Proliferation in Pulmonary Metastasis.
Mentor: Ruth Muschel
Department: Psychology, School of Medicine
Student: Kelli Russel
Title of Project: Feline Hyperthyroidism: Determination of Differential Activation of G s a and G i a Proteins in Response to Thyrotropin Treatment.
Mentor: Cindy Ward
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Sara Ryan
Title of Project: Immune Function in Canine X-linked Hypohidrotic Ectodermal Dysplasia.
Mentor: Margaret Casal
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Todd Strochlic
Title of Project: A Possible Nuclear Role for a Msb3p-Tci1p Complex in the Development of Cell Polarity.
Mentor: Erfei Bi
Department: Cell and Developmental Biology, School of Medicine
Student: Kathryn Vickery
Title of Project: An In Vitro and In Vivo Study on the Role of Various Cytokines in Promoting IL-10 Producing Cells in Leishmania major Infections.
Mentor: Philip Scott
Department: Pathobiology, Veterinary Medicine
Student: Fred Wininger
Title of Project: Biomechanical Optimization of Dynamic Compression Plate Fixation for Arthrodesis of the Carpal Joint in the Dog.
Mentor: Gail Smith
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Steven Zedler
Title of Project: AAV Transduction of Condrocytes in Equine Cartilage Explant Culture.
Mentor: Dean Richardson
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
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Funded Projects - 2001
Student: Beth Appleman
Title of Project: Characterization of the Altered Glycosaminoglycans and Proteoglycans in Collagen X Transgenic and Null Mice.
Mentor: Olena Jacenko
Department: Animal Biology, Veterinary Medicine
Student: Raul Casas-Dolz
Title of Project: Differential Gene Expression in Stallions with Testicular Degeneration.
Mentor: Regina Turner
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Rebecca Garabed
Title of Project: Zoopork – Prevalence of Zoonotic Pathogens in Different Housing Systems for Fattening Pigs.
Mentor: Helen Wheeler-Aceto and Shelley Rankin
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Daniel Hall
Title of Project: Demonstration of Viscerotropy Within Barrington’s Nucleus in Rats.
Mentor: Richard Miselis
Department: Animal Biology, Veterinary Medicine
Student: Deborah Hirschmann
Title of Project: A Minimal Genome-Wide Scan for Patent Ductus Arteriosus (PDA) Using DNA from a Large Informative Canine Family.
Mentor: Paula Henthorn
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Alice Hsu
Title of Project: Endocrine Regulation of a Novel Form of Adenylyl Cyclase in the Male Reproductive Tract.
Mentor: Gregory Kopf
Department: OB-GYN, Medicine
Student: Jennifer Kaae
Title of Project: Analysis of the Immune Status in Collagen X Defective Mice.
Mentor: Olena Jacenko
Department: Animal Biology, Veterinary Medicine
Student: Colleen Kane
Title of Project: Role of NF-kB in T Cell Survival.
Mentor: Chris Hunter
Department: Pathobiology, Veterinary Medicine
Student: Kimberly Kovath
Title of Project: An Evaluation of Thromboelastography in Dogs with Immune-Mediated Hemolytic Anemia.
Mentor: Cindy Otto
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Emily Kupprion
Title of Project: Coal Flyash as Dairy Bedding Amendments for Mastitis Bacteria Control.
Mentor: Zhengxia Dou
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Chung Lee
Title of Project: Mechanism of E47-Pip DNA Binding and Transcriptional Synergy.
Mentor: Michael Atchison
Department: Animal Biology, Veterinary Medicine
Student: Mark Lopez
Title of Project: The Anatomy and Function of Specific Sensory Neurons in Three Species of Parasitic Nematodes and One Free-Living Nematode Species.
Mentor: Gerry Schad
Department: Pathobiology, Veterinary Medicine
Student: Julie McDade
Title of Project: The Effect of Fimbriae Expression Salmonella enteric Serovar Enteritidis on Heeterophil and Monocyte Response in Chickens.
Mentor: Dieter Schifferli and Wil Weber
Department: Pathobiology, Veterinary Medicine
Student: Anne Skope
Title of Project: Cloning and Expression of Non-Human Primate DC-SIGNR.
Mentor: Robert Doms
Department: Pathology, Medicine
Student: Amy Snedaker
Title of Project: Investigation of the Developmental Potential of Porcine Spermatogenic Cells in Organ Culture and Tissue Grafts.
Mentor: Ina Dobrinski
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Todd Strochlic
Title of Project: Analysis of the Interaction Between PLAC-24 and CLIP-115.
Mentor: Erika Holzbaur
Department: Animal Biology, Veterinary Medicine
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Funded Projects - 2000
Student: Brady Beale
Title of Project: Improving fertility of cryopreserved canine semen.
Mentor: Cindy Ward
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Danalyn Dess
Title of Project: Role of soluble adenylyl cyclase in regulating metabolic changes during sperm capacitation.
Mentor: Stuart Moss
Department: Cell and Developmental Biology
Student: Tracy Anne Filler
Title of Project: Identification of erythrocyte pyruvate kinase deficiency in long hair Dachshund, Chihuahua, and Toy Eskimo dogs.
Mentor: Urs Giger
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Alfredo Geigel
Title of Project: Identification, localization, and binding specificity of trout C3b receptors.
Mentor: Oriol Sunyer
Department: Pathobiology
Student: Dan Hall
Title of Project: Generation of cDNA libraries from male germ cells in goats.
Mentor: Ina Dobrinski
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Alexander Hamberg
Title of Project: Adeno-associated virus induction of alpha-L-iduronidase cDNA in Mucopolysaccharidosis I kittens.
Mentor: Mark Haskins
Department: Pathobiology
Student: Colleen Kane
Title of Project: Immunocompetence of murine fetal liver cells in mixed lymphcyte reactions.
Mentor: Margaret Casal
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Eric Lombardini
Title of Project: Zoonotic transmission of helminth parasitism from the consumption of wildlife in Bioko, Equatorial Guinea
Mentor: Gerry Schad
Department: Pathobiology
Student: Katherine Masek
Title of Project: Expression and localization of soluable adenylyl cyclase in murine oocytes.
Mentor: Carmen Williams
Department: OB/GYN
Student: Julie McDade
Title of Project: Effect of fimbriae expression in Salmonella enteritidis on heterophil and moncyte response in chickens.
Mentor: Dieter Schifferli
Department: Pathobiology
Student: Catherine McManus
Title of Project: In vitro mucosal effects of short chain fatty acids in the canine and feline colon.
Mentor: Robert Washabau
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Courtney North
Title of Project: Identification of Rab3 proteins involved in sperm acrosomal exocytosis.
Mentor: Cindy Ward
Department: Clinical Studies, Philadelphia, Veterinary Medicine
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Funded Projects - 1999
Student: Christine Adreani
Title of Project: The Cloning and Expression of a Functional Equine Tissue Inhibitor of Matrix Metalloproteinase - 1.
Mentor: Dr. Dean Richardson
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Amy Bucher
Title of Project: Effects of Drug Therapies on Blood Flow to the Equine Hoof.
Mentor: Dr. Eric Birks
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: David J. Champaigne
Title of Project: Benzodiazepine Influences on Amygdalar Modulation of Sleep.
Mentor: Dr. Larry D. Sanford
Department: Animal Biology, Veterinary Medicine
Student: Catherine Cheng
Title of Project: REM-A as a Model of REM Behavior Disorder (RBD).
Mentor: Dr. Adrian Morrison
Department: Animal Biology, Veterinary Medicine
Student: Rosalind S. Chow
Title of Project: The use of reduced and oxidized glutathione levels in serum and erythrocytes as indicators of reperfusion injury following blunt vehicular trauma in dogs.
Mentor: Dr. Cynthia M. Otto
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Sherri S. Cokefair
Title of Project: Serum Tumor Necrosis Factor Levels in Dogs Following Blunt Vehicular Trauma.
Mentor: Dr. Cynthia Otto
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Jennifer W. Gschwend
Title of Project: Estimates of Heritability of Hip Scores in Golden Retrievers.
Mentor: Dr. Gail K. Smith
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Meryl Gupta
Title of Project: Cdc42-Responsive Elements in the Cyclin A Promoter.
Mentor: Dr. Margaret M. Chou
Department: Cell and Developmental Biology, Medicine
Student: Aspen A. Hammond
Title of Project: The Effect of Training on Bone Modulus in Thoroghbred Racehorses: A Biochemical Study.
Mentor: Dr. David Nunamaker
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Kristina Lu
Title of Project: Genetic Imprinting in Androgenetic Mouse Chimeras.
Mentor: Dr. K. John McLaughlin
Department: Animal Biology, Veterinary Medicine
Student: Katherine Masek
Title of Project: Expression and Localization of Glucose Transporter Proteins in Murine Sperm and Developing Male Germ Cells.
Mentor: Prof. Gregory S. Kopf
Department: OB-GYN, Medicine
Student: Catherine M. McManus
Title of Project: Effects of Fiber Fermentation Metabolites on Feline Gastrointestinal Function: Smooth Muscle Contractility and Mucosal Transport.
Mentor: Drs. Kathryn Michel
and Robert Washabau
Department: Clinical Studies, Philadelphia, Veterinary Medicine
Student: Aliza Moldofsky
Title of Project: Health and Productivity of Dairy Cows Following Rumenocentesis: A Risk Assessment Study.
Mentor: Dr. Helen Wheeler-Aceto and Dr. James Ferguson
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Robert Richardson
Title of Project: Osteonal Trajectories in Equine Cortical Bone: Relationships of Primary and Secondarty Osteons with Exercise.
Mentor: Dr. David Nunamaker
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Katherine Wentworth
Title of Project: The Effects of Cryopreservation on Hyaluronidase Activity in Equine Sperm.
Mentor: Dr. Stuart Meyers
Department: Clinical Studies, New Bolton Center, Veterinary Medicine
Student: Steve West
Title of Project: Immunomagnetic Separation (IMS) as a Method for Isolating Mycobacterium paratuberculosis (M.ptb) from Ruminant Fecal Samples.
Mentor: Dr. Robert Whitlock
Department: Clinical Studies, New Bolton Center, Veterinary Medicine