Dr. Bruce Freedman
Associate Professor of Pathobiology
School of Veterinary Medicine, University of Pennsylvania
Dr. Freedman's work focuses on physiological processes that regulate lymphocyte and macrophage development and function, and the viral and cellular determinants of viral tropism and pathogensis. His lab has focused on the signal transduction pathways activated in human macrophages and T cells by HIV-1 envelope protein (gp120) upon interaction with CD4 and chemokine receptors. The lab's goal is to understand the functional consequences of signaling on virus entry, post-entry steps of viral replication, and the consequences on target cell functions apart from infection.