Penn Veterinary Medicine | University of Pennsylvania

Research

 

Current research interests and selected publications

The research program is focused on clinical research in dentistry and oral surgery. Our primary goals are to prevent disease and to optimize patient care. This can be accomplished by

• Enhancing knowledge of oral pathology development and
• Expanding diagnosis and treatment options

Clinical research makes use of existing patient material by maintaining comprehensive medical and dental records, collecting specimens (tissue and fluid samples), and ensuring adequate follow-up. Investigational studies on privately owned animals are sometimes performed (e.g., on patients with oral cancer when available treatment options have failed or are declined by the owner), require consent by the patient owner, and must be approved by the University of Pennsylvania Institutional Animal Care and Use Committee (IACUC).

 

Current research interests

 

Periodontal disease

• Evaluation of associations between oral disease and kidney health in cats
• Assessment of the effectiveness of dietary reduction of plaque and calculus in the management of dogs with diabetes
• Validation of scoring techniques and teeth sets for assessment of periodontal disease in dogs and cats
• Investigations of the carnivore periodontal biofilm in health and disease

 

Periodontal surgery

• Apically positioned flaps in periodontal pocket prevention and crown lengthening procedures in dogs
• Laterally positioned flaps for repair of gingival defects in dogs

Tooth resorption

• Evaluation of associations between oral disease and kidney health in cats
• Evaluation of epidemiological and laboratory data in dogs with tooth resorption
• Histological studies of tooth resorption in dogs and cats

Back to Top

Palate surgery

• Management of congenital defects and defects acquired after birth of the hard and soft palate in dogs

 

Oral and maxillofacial trauma

• Interdental wiring and intraoral resin splinting in dogs with mandibular and maxillary fractures
• Modified Risdon wiring technique and intraoral resin splinting for repair of jaw fractures in dogs
• Osseous wiring alone or combined with non-invasive techniques for management of mandibular fractures in dogs

 

Oral and maxillofacial cancer

• Lymphatic staging and sentinel lymph node identification in canine oral malignant melanoma
• Treatment of feline oral squamous cell carcinoma (SCC) with 2-difluoromethylornithine (DFMO)
• Mandibulectomy procedures in the treatment of squamous cell carcinoma in cats
• Extent of tongue resection and quality of life maintenance in cats and dogs with lingual neoplasia or trauma

 

Soft tissue and bone reconstruction

• Bone grafting techniques for reconstruction of mandibular defects in dogs

 

Others

• Evaluation of use of antibiotics in the management of patients with oral diseases
• Survey of oral and dental disease and management in dogs and cats at US animal shelters
• Use of computed tomography in the diagnosis of masticatory muscle disorders
• Oral and dental presentations in dogs with ectodermal dysplasia
• Prevalence, diagnosis and treatment of dental disease in rescued ferrets

Back to Top

Selected publications

• Berent AC, Weisse C, Rondeau MP, Reiter AM. Balloon-expandable metallic stent placement for benign nasopharyngeal stenosis in three dogs and three cats. Journal of the American Veterinary Medical Association (accepted).
• Lewis JR, Okuda A, Shofer FS, Pachtinger G, Harvey CE, Reiter AM. Significant association between tooth extrusion and tooth resorption in domestic cats. Journal of Veterinary Dentistry (in press).
• Harvey CE, Laster L, Shofer FS. The Total Mouth Periodontal Scoring system. Journal of Veterinary Dentistry (in press).
• Mohn KL, Jacks TM, Schleim KD, Harvey CE, Miller BR, Halley B, Feeney WP, Hill SL, Hickey G. Alendronate binds to tooth root surfaces and inhibits progression of feline tooth resorption: A pilot proof-of-concept study. Journal of Veterinary Dentistry (in press).
• Reiter AM, Lewis JR. Dental bulge restoration and gingival collar expansion after endodontic treatment of a complicated maxillary fourth premolar crown-root fracture in a dog. Journal of Veterinary Dentistry 2008; 25: 34-45.
• Reiter AM, Schwarz T. Computed tomographic appearance of masticatory myositis in dogs: 7 cases (1999-2006). Journal of the American Veterinary Medical Association 2007; 231: 924-930.
• Lewis JR, Tsugawa AJ, Reiter AM. Use of CO2 laser as an adjunctive treatment for caudal stomatitis in a cat. Journal of Veterinary Dentistry 2007; 24: 240-249.
• Reiter AM. Dental surgical procedures. In: Tutt C, Deeprose J, Crossley D (eds). BSAVA Manual of Canine and Feline Dentistry, BSAVA, Gloucester, 2007, 178-195.
• Casal ML, Lewis JR, Mauldin EA, Tardivel A, Ingold K, Favre M, Paradies F, Demotz S, Gaide O, Schneider P. Significant correction of disease after postnatal administration of recombinant EDA in canine X-linked ectodermal dysplasia. American Journal of Human Genetics 2007; 81: 1050-1056.
• Gawor JP, Reiter AM, Jodkowska K, Kurski G, Wojtacki MP, Kurek A. Influence of diet on oral health in cats and dogs. Journal of Nutrition 2006; 136: 2021S-2023S.
• Blazejewski S, Lewis JR, Reiter AM. Mucoperiosteal flap for extraction of multiple teeth in the maxillary quadrant of the cat. Journal of Veterinary Dentistry 2006; 23: 200-205.
• Radice M, Martino AM, Reiter AM. Evaluation of subgingival bacteria in the dog and their susceptibility to commonly used antibiotics. Journal of Veterinary Dentistry 2006; 23: 219-224.
• Lipscomb V, Reiter AM. Surgical materials and instrumentation. In: Brockman DJ, Holt DE (eds). BSAVA Manual of Canine and Feline Head, Neck and Thoracic Surgery, BSAVA, Gloucester, 2005, 16-24.
• Reiter AM, Smith MM. The oral cavity and oropharynx. In: Brockman DJ, Holt DE (eds). BSAVA Manual of Canine and Feline Head, Neck and Thoracic Surgery, BSAVA, Gloucester, 2005, 25-43.
• Reiter AR, Lewis JR, Okuda A. Update on the etiology of tooth resorption in the domestic cat. Veterinary Clinics of North America Small Animal Practice 2005; 35: 913-942.
• Harvey CE. Management of periodontal disease: Understanding the options. Veterinary Clinics of North America Small Animal Practice 2005; 35: 819-836.

• Lewis JR, Reiter AM. Management of generalized gingival enlargement in a dog – Case report and review of the literature. Journal of Veterinary Dentistry 2005; 22: 160-169.
• Rawlinson JE, Reiter AM. Repair of a gingival cleft associated with a maxillary canine tooth in a dog. Journal of Veterinary Dentistry 2005; 22: 234-242.
• Reiter AM, Lyon KF, Nachreiner RF, Shofer FS. Evaluation of calciotropic hormones in cats with odontoclastic resorptive lesions. American Journal of Veterinary Research 2005; 66: 1446-1452.
• Reiter AM, Lewis JR, Rawlinson JE, Gracis M. A case series study on hemisection of carnassial teeth in client-owned dogs. Journal of Veterinary Dentistry 2005; 22: 216-226.
• Reiter AM. Symphysiotomy, symphysiectomy and intermandibular arthrodesis in a cat with open-mouth jaw locking - case report and literature review. Journal of Veterinary Dentistry 2004; 21: 147-158.
• Reiter AM, Brady CA, Harvey CE. Local and systemic complications in a cat after poorly performed dental extractions. Journal of Veterinary Dentistry 2004; 21: 215-221.
• Harvey CE, Orsini PG, McLahan C, Schuster C. Mapping of the radiographic central point of feline dental resorptive lesions. Journal of Veterinary Dentistry 2004; 21: 15-21.
• Harvey CE. Shape and size of teeth of dogs and cats: Relevance to studies of plaque and calculus accumulation. Journal of Veterinary Dentistry 2002; 19: 186-195.
• Reiter AM, Mendoza KA. Feline odontoclastic resorptive lesions. An unsolved enigma in veterinary dentistry. Veterinary Clinics of North America Small Animal Practice 2002; 32: 791-837.
• Gioso MA, Shofer F, Barros PSM, Harvey CE. Mandible and mandibular first molar tooth measurements in dogs: Relationship of radiographic height to body weight. Journal of Veterinary Dentistry 2001; 18: 65-68.
• Reiter AM. Feline odontolysis in the 1920s – the forgotten histopathological studies of feline odontoclastic resorptive lesions. Journal of Veterinary Dentistry 1998; 15: 35-41.
• Harvey CE. Periodontal disease in dogs: Etiology, pathogenesis and prevalence. Veterinary Clinics of North America Small Animal Practice 1998; 28: 1111-1128.
• Gracis M, Harvey CE. Radiographic study of the maxillary canine tooth in mesaticephalic dogs. Journal of Veterinary Dentistry 1998; 15: 73-76.
• Harvey CE. Aging horses by examining the teeth. A centuries old inexact science. Journal of Veterinary Dentistry 1997; 14: 97-98.
• Harvey CE, Shofer F, Laster L. Correlation of diet, other chewing activities and periodontal disease in North American client-owned dogs. Journal of Veterinary Dentistry 1996; 13: 101-110.
• DeBowes LJ, Mosier D, Logan E, Harvey CE, Lowry S, Richardson DC. Association of periodontal disease and histologic lesions in multiple organs from 45 dogs. Journal of Veterinary Dentistry 1996; 13: 57- 60.
• Anderson MA, Orsini PG, Harvey CE. Temporomandibular ankylosis: treatment by unilateral condylectomy in two dogs and two cats. Journal of Veterinary Dentistry 1996; 13: 23-26.
• Hennet P, Harvey CE. Root canal anatomy in the cat. American Journal of Veterinary Research 1996; 57: 1545-1548.
• Harvey CE, Thornsberry C, Miller BR, Shofer FS. Antimicrobial susceptibility of sub-gingival flora in cats with gingivitis. Journal of Veterinary Dentistry 1995; 12: 157-160.
• Harvey CE, Thornsberry C, Miller BR, Shofer FS. Antimicrobial susceptibility of sub-gingival bacterial flora in dogs with gingivitis. Journal of Veterinary Dentistry 1995; 12: 151-156.
• Harvey CE, Thornsberry C, Miller BR. Subgingival bacteria - comparison of culture results in dogs and cats with gingivitis. Journal of Veterinary Dentistry 1995; 12: 147-150.
• Okuda A, Harvey CE, Flax BR. Challenges in treatment of external odontoclastic resorptive lesions in cats. Compendium on Continuing Education of the Veterinary Practitioner 1995; 17: 1461-1469.
• Harvey CE. The history of veterinary dentistry, part one: From the earliest record to the end of the 18th century. Journal of Veterinary Dentistry 1994; 11 (4): 135-139.
• Harvey CE, Shofer F, Laster L. Association of age and body weight with periodontal disease in North American dogs. Journal of Veterinary Dentistry 1994; 11 (3): 94-105.
• Sarkiala E, Dambach, D, Harvey CE. Jaw lesions resulting from renal hyperparathyroidism in a young dog - a case report. Journal of Veterinary Dentistry 1994; 11 (2): 121-124.
• Miller BR, Harvey CE. Compliance with oral hygiene recommendations following periodontal treatment in client-owned dogs. Journal of Veterinary Dentistry 1994; 11 (1): 18-19.
• Miller BR, Harvey CE, Shofer F. Effectiveness of SofScale Calculus Scaling Gel as an aid during dental scaling of teeth of dogs. Journal of Veterinary Dentistry 1994; 11 (1): 14-17.

• Miller BR, Harvey CE. Dental instrument sharpening. Veterinary Technician 1994; 15 (1): 29-32, 48.
• Miller BR, Harvey CE. Ultrasonic scaling: Practical procedures and techniques. Compendium on Continuing Education for the Practicing Veterinarian 1994; 16: 743-746, 749-751.
• Sheridan O, Wortman J, Harvey C, Hayden J, Haskins M. Craniofacial abnormalities in animal models of mucopolysaccharidoses I, VI, and VII. Journal of Craniofacial Genetics and Developmental Biology 1994; 14 (1): 7-15.
• Harvey CE, Emily PP. Small Animal Dentistry. Mosby-Year Book, Inc., St. Louis 1993.
• Sarkiala E, Harvey CE. Systemic antimicrobials in the treatment of periodontitis in dogs. Seminars in Veterinary Medicine and Surgery 1993; 8: 197-203.
• Harvey CE. Feline dental resorptive lesions. Seminars in Veterinary Medicine and Surgery 1993; 8: 187-196.
• Harvey CE, Hammond BF. Bacterial isolates from blood cultures of dogs undergoing dentistry. Veterinary Surgery 1993; 22: 327-329.
• Anderson JG, Harvey CE. Masticatory muscle myositis. Journal of Veterinary Dentistry 1993; 10 (1): 6-8.
• Harvey CE. Feline Dentistry. Veterinary Clinics of North America. W. B. Saunders Company, Philadelphia 1992.
• Hennet PR, Harvey CE. Natural development of periodontal disease in the dog: A review of clinical, anatomical and histological features. Journal of Veterinary Dentistry 1992; 9 (3): 13-19.
• Hennet PR, Harvey CE, Emily PP. The Angle classification system of malocclusion - is it appropriate for use in veterinary dentistry? Journal of Veterinary Dentistry 1992; 9 (3): 10-12.
• Hennet PR, Harvey CE. Diagnostic approach to malocclusions in dogs. Journal of Veterinary Dentistry 1992; 9 (2): 23-26.
• Hennet PR, Harvey CE. Craniofacial development and growth in the dog: A review. Journal of Veterinary Dentistry 1992; 9 (2): 11-18.
• Van Wessum R, Harvey CE, Hennet P. Feline dental resorptive lesions. Prevalence patterns. Veterinary Clinics of North America Small Animal Practice 1992; 22: 1405-1416.
• Okuda A, Harvey CE. Etiopathogenesis of feline dental resorptive lesions. Veterinary Clinics of North America Small Animal Practice 1992; 22: 1385-1404.
• Harvey CE, Flax BM. Feline oral-dental radiographic examination and interpretation. Veterinary Clinics of North America Small Animal Practice 1992; 22: 1279-1295.
• Rabinowitz JF, Sheridan O, Craig RG, Feldman R, Grossman ER, Harvey CE, Haskins ME. Lipid composition and biosynthesis in the gingiva of the domestic cat. Journal of Periodontology 1991; 62: 495-498.

• Hennet PR, Harvey CE. Spirochetes in periodontal disease in the dog: a review. Journal of Veterinary Dentistry 1991; 8 (3): 16-17.
• Hennet PR, Harvey CE. Anaerobes in periodontal disease in the dog: a review. Journal of Veterinary Dentistry 1991; 8 (2): 18-21.
• Hennet PR, Harvey CE. Aerobes in periodontal disease in the dog: a review. Journal of Veterinary Dentistry 1991; 8 (1): 9-11.
• Knowles JO, Dawson S, Gaskell RM, Gaskell CJ, Harvey CE. Neutralization patterns amongst recent British and North American feline calicivirus isolates from different clinical origins. Veterinary Record 1990; 127 (6):125-127.
• Harvey CE, Newton CD, Schwartz A. Small Animal Surgery. JB Lippincott, Philadelphia 1990.
• Harvey CE, Orr HS. BSAVA Manual of Small Animal Dentistry. British Small Animal Veterinary Association, Cheltenham 1990.
• Knowles J, Gaskell RM, Gaskell CJ, Harvey CE, Lutz H. Prevalence of feline calicivirus, feline leukemia virus, and antibodies to FIV in cats with chronic stomatitis. Veterinary Record 1989; 124: 336 338.
• Zetner K, Kampfer P, Lutz H, Harvey C. Vergleichende immunologische und virologische Untersuchungen von Katzen mit chronischen oralen Erkrankungen. Wiener Tierarztliche Monatschrift 1989; 76: 303 308.
• Mallonnee D, Harvey CE, Venner M, Hammond BF. Bacteriology of periodontal disease in the cat. Archives of Oral Biology 1988; 33: 677-683.
• Harvey CE. Palate defects in dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian 1987; 9: 405-418.
• Harvey CE. Oral surgery: Radical resection of maxillary and mandibular lesions. Veterinary Clinics of North America Small Animal Practice 1986; 16: 983-993.
• Emms SG, Harvey CE. Results following maxillectomy in dogs and cats. Journal of Small Animal Practice 1986; 27: 291-306.
• Harvey CE. Veterinary Dentistry. W. B. Saunders Company, Philadelphia 1985.
• Harvey CE. Oral surgery. Veterinary Annual 1985; 25: 284-291.
• Golden AM, Stoller NH, Harvey CE. Survey of oral and dental disease in dogs anesthetized at a veterinary hospital. Journal of the American Animal Hospital Association 1982; 18: 891-899.
• Harvey CE. Parotid gland enlargement and hypersialosis in a dog. Journal of Small Animal Practice 1981; 22: 19-23.
• Harvey CE. Parotid salivary duct rupture and fistula in the dog and cat. Journal of Small Animal Practice 1977; 18: 163-167.
• Harvey CE. Oral surgery in the dog. Veterinary Annual 1973; 14: 110-113.
• Harvey CE, Koch SA. Surgical complications of parotid duct transposition in the dog. Journal of the American Animal Hospital Association 1971; 7: 122-126.
• Harvey CE. Sialography in the dog. Journal of the American Veterinary Radiology Society 1969; 10: 18-27.
• Harvey CE. Canine salivary mucocele. Journal of the American Animal Hospital Association 1969; 5: 155-165.