Penn Veterinary Medicine | University of Pennsylvania

Research at Penn Vet Radiology

Tumor micro-perfusion evaluated with Power Doppler in a Murine model (Image courtesy of Dr Gabriela Seiler)

Structure and Areas of Expertise

The Section of Radiology is actively engaged in research that ranges from basic science to clinical applications to new technologies. Research is an important part of our activity and our faculty is involved in many individual and collaborative research projects. The integration of our section within our multi-disciplinary hospital along with the proximity of the medical school, dental school and engineering school stimulates research at Penn Vet Radiology.

The main areas of interest and expertise include:

• Contrast-Enhanced Ultrasound (CE-US):
  • Tumor perfusion assessment with potential for developing ultrasound-driven targeted chemotherapy;
  • Non invasive assessment of the effect of novel cancer treatments on tumor neo-vascularization and perfusion;
  • Use of contrast enhanced ultrasound to non-invasively detect lack of perfusion to some organs and thereby detect vascular compromise.
• Vascular imaging, using contrast enhanced dynamic computed tomography (CT) or magnetic resonance angiography (MRA):
  • Anatomic diagnosis of vascular anomalies;
  • Screening of organ donors.
• Pulmonary imaging especially with computed tomography.
• Evidence based imaging – clinical research in diagnostic imaging.
• High-resolution imaging and its application to non invasive imaging of laboratory rodents. The proximity of a research core facility at the medical school, the small animal imaging facility, helps developing collaborative research between researchers at the medical school and the veterinary school.

 

Publications

Contrast Enhanced Renal Micro-computed tomography in a Murine model (Image courtesy of Dr Wilfried Mai)

 

 

 

 

 

 

 

 

Over the past years, these research projects have led to numerous publications in various scientific journals both in veterinary medicine and human medicine. A list of the publications from the Penn Vet Radiology faculty is presented below:

Wilfried Mai, Dr Med Vet, MS, PhD, DACVR, DECVDI, Assistant Professor of Radiology
Jeffrey Wortman, VMD, PhD, DACVR, Associate Professor of Radiology
Jennifer Adolf Reetz, DVM, DACVR, DACVIM, Staff Veterinarian in Radiology
Ana Caceres, DVM, DACVR, Staff Veterinarian in Radiology
Yael Porat-Mosenco, DVM, DECVDI, Staff Veterinarian in Radiology

 

                     Contrast-enhanced renal MRA in a dog

(Image courtesy of Dr Wilfried Mai)

 

 

 

 

 

 

WILFRIED MAI, Dr Med Vet, PhD, DACVR, DECVDI, Cert Clin Res - ASSISTANT PROFESSOR OF RADIOLOGY

 

1. Pouchelon J.L., Chetboul V., Delisle F., Devauchelle P., Mai W., Vial V. "Diagnosis of pulmonary thrombo-embolism in a cat using echocardiography and pulmonary scintigraphy", J Small Anim Pract. 1997, 38: 306-310.
2. Mai W., Ledieu D., Venturini L., Fournel C., Fau D., Palazzi X., Magnol J.P. "Ultrasonographic appearance of intra-abdominal granuloma secondary to retained surgical sponges", Vet Radiol Ultrasound. 2001, 42: 157-160.
3. Mai W., Janier M.F., Allioli N., Quignodon L., Chuzel T., Flamant F., Samarut J. "Thyroid hormone receptor ? is a molecular switch of cardiac function between fetal and post-natal life." Proc Natl Acad Sci USA. 2004; 101:10332-7.
4. Sappey-Marinier D., Beuf O., Billotey C., Chereul E., Dupuy J., Jeandey M., Grenier D., Hasserodt J., Langlois J.B., Lartizien C., Mai W., Odet C., Samarut J., Vray D., Zimmer L., Janier M. "The ANIMAGE project: a multimodal imaging platform for small animal research." Nucl Instr Meth Phys Res A. 2004; 527:117-123.
5. Mai W., Le Floc’h J., Vray D., Samarut J., Barthez P., Janier M. "Evaluation of cardiovascular flow characteristics in the 129Sv mouse fetus using color-Doppler-guided spectral Doppler ultrasound." Vet Radiol Ultrasound. 2004; 45:568-573.
6. Mai W., Barraud L., Lefrancois L., Scoazec J.Y., Guerret S., Vray D., Merle P., Vitvitski-Trepo L., Trepo C., Janier M.F. "Ultrasound detection of spontaneous hepato-cellular carcinomas in X/myc bitransgenic mice." Liver International. 2004; 24:651-657.
7. Chuzel T., Mai W., Ponce F. "What is your diagnosis? Abdominal distension with loss of intra-abdominal contrast and decreased visibility of serosal surfaces of the small and large intestines." J Am Vet Med Assoc. 2004; 224:1921-2.
8. Mai W., Badea C.T., Wheeler C.T., Hedlund L.W., Johnson G.A. "Effects of breathing and cardiac motion on the spatial resolution in microscopic imaging of rodents." Magn Reson Med. 2005; 53:858-865.
9. Chuzel T., Bublot I., Mai W. "What Is Your Diagnosis? Primary hyperparathyroidism in a dog." J Am Vet Med Assoc. 2005; 226:203-204.
10. Brown S.D.M., Chambon P., Hrabe de Angelis M. & The EUMORPHIA Consortium. "EMPReSS: standardized phenotype screens for functional annotation of the mouse genome." Nature Genetics. 2005; 37:1155.
11. Reetz J.A., Mai W., Muravnick K.B, Goldschmidt M., Schwarz T. "CT evaluation of anatomic and pathologic variations in the feline nasal septum and paranasal sinuses." Vet Radiol Ultrasound. 2006; 47:321-327.
12. Carme S., Mai W., Mazzadi A., Janier M., Revel D., Magnin I., Wiart M., Neyran B., Canet-Soulas E. "Importance of parametric mapping and deconvolution in analyzing magnetic resonance myocardial perfusion images." Invest Radiol. 2006; 41:374-383.
13. Wiart M., Carme S., Mai W., Larsson H.B.W., Neyran B., Canet-Soulas E. "In vivo quantification of regional myocardial blood flow: validity of the fast-exchange approximation for intravascular T1 contrast agent and long inversion time." Magn Reson Med. 2006;56:340-347.
14. Mai W. "The hilar peri-venous hyperechoic triangle: another sign of acute splenic torsion in dogs." Vet Radiol Ultrasound. 2006; 47:487-491.
15. Kinns J., Mai W., Seiler G., Zwingenberger A., Johnson V., Cáceres A., Valdés-Martínez A., Schwarz T. "Radiographic sensitivity and negative predictive value for acute canine spinal trauma" Vet Radiol Ultrasound. 2006; 47:563-570.
16. Spriet M., Mai W., Mc Knight A. "Asymmetric signal intensity in normal collateral ligaments of the distal interphalangeal joint in horses with a low field MRI system: a manifestation of the magic angle effect" Vet Radiol Ultrasound. 2007; 48:95-100.
17. Chuzel T., Couturier L., Nicolier A., Bublot I., Mai W., Cadore J.L. "Persistent truncus arteriosus in a cat." J Vet Cardiol. 2007; 9:43-46
18. Valdés-Martínez A., Cianciolo R., Mai W. "Association between renal hypoechoic subcapsular thickening and lymphosarcoma in cats". Vet Radiol Ultrasound. 2007; 48:357-360.
19. Kinns J., Mai W. "Association between malignancy and sonographic heterogeneity in canine and feline abdominal lymph nodes". Vet Radiol Ultrasound. 2007; 48:565-569.
20. Mai W., Cáceres A.V. "Dual-phase computed tomographic angiography in three dogs with pancreatic insulinoma." Vet Radiol Ultrasound. 2008; 49:141-148.
21. Valdés-Martínez A., Seiler G*., Mai W., Bolt D.M., Mudge M., Dukti S.A., Hubert J.D. "Quantitative analysis of scintigraphic findings in tibial stress fractures in Thoroughbred racehorses." Am J Vet Res. 2008; 69:886-890.
22. Cáceres A.V., Zwingenberger A.L., Aronson L.R., Mai W. "Characterization of normal feline renal vascular anatomy with dual-phase CT angiography." Vet Radiol Ultrasound. 2008; 49:350-356.
23. Ivancic M., Mai W. "Qualitative and quantitative comparison of renal vs. hepatic ultrasonographic intensity in healthy dogs." Vet Radiol Ultrasound. 2008; 49:368-373.
24. Mai W. "Pseudo-layering artifact on post-contrast magnetic resonance images of the bladders of 18 dogs and three cats." Vet Rec. 2008; 163:116-119.
25. Cavrenne R., Mai W. "Time-resolved renal contrast-enhanced MRA in normal dogs." Vet Radiol Ultrasound. 2009; 50:58–64.
26. Mai W. "Multi-phase time-resolved contrast enhanced portal MRA in normal dogs." Vet Radiol Ultrasound. 2009; 50:52–57.

 

 

PW-Doppler examination of the

umbilical cord in a 13 days mouse fetus

(Image courtesy of Dr Wilfried Mai)

 

 

 

 

 

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JEFFREY WORTMAN, VMD, PhD, DACVR, ASSOCIATE PROFESSOR OF RADIOLOGY

1. Wortman, JA, Zontine WJ: Prostatic Disease. Radiographic Interpretation. Modern Veterinary Practice, 56(7): 485-490, July, 1975.
2. Crow, SE, Hall, AD, Walshaw R, Wortman, JA: Giant Cell Tumor in a Dog. JAAHA, 15(4):473-476, 1979.
3. Crow, SE, Bell, TG, Wortman, JA: Hematuria Associated with Renal Hemangiosarcoma in a Dog: JAVMA, 176(6):531-533, 1980.
4. Carrig, CB, Wortman, JA, Morris, EL, Blevins, WE, Root, CR, Hanlon, G, Suter, PF: Ectrodactyly (Split-hand Deformity) in the Dog. Veterinary Radiology, 22(3):123-143, 1981.
5. Carrig, CB, Wortman JA: Acquired Dysplasias of the Canine Radius and Ulna. Compendium on Continuing Education, 3:557-564, 1981. [This article was republished in The Compendium Collection Radiology in Practice, Veterinary Learning Systems Co., Inc., Trenton, NJ, 1994]
6. Stick, JA, Krehbiel, JD, Kunze, DJ, Wortman, JA: Esophageal Healing in the Pony: A Comparison of Sutured vs. Non-sutured Esophagotomy. Amer J Vet Res, 42(9):1506-1513, 1981.
7. Eigenmann, JE, Wortman, JA, Haskins, ME. Elevated Growth Hormone Levels and Diabetes Mellitus in a Cat with Acromegalic Features. JAAHA, 20:747-752, 1984.
8. Haskins, ME, Wortman, JA, Wilson, S, Wolfe, JH: Bone Marrow Transplantation in the Cat. Transplant¬ation, 37(6):634-636, 1984.
9. Villa Godoy, A, Ireland, JJ, Wortman, JA, Ames, NK, Hughes, TL, Fogwell, RL: Effect of Ovarian Follicles on Luteal Regression in Heifers. J An Sci, 60(2):519 527, 1985.
10. Fogwell, RL, Cowley, JL, Wortman, JA, Ames, NK, Ireland, JJ: Luteal Function in Cows Following Destruction of Ovarian Follicles at Midcycle. Theriogenology, 23(2):389-398, 1985.
11. Goldstein, EJ, Burnett, KR, Wortman, JA, Wolf, GL, Joseph, P, Sen, S: Contrast Enhancement of Spon¬taneous Animal CNS Tumors: Correlation of MR with CT. Physiol Chem Phys Med NMR, 17:113 122, 1985.
12. Lang, J, Wortman, JA, Glickman, LT, Biery, DN, Rhodes, WH: Sensitivity of Radiographic Detection of Lung Metastases in the Dog. Veterinary Radiology, 27(3):74-78, 1986.
13. Tilley, LP, Miller, MS, Wortman, JA, Biery, DN, Coward, BH: Teleradiology in Veterinary Medicine. Semin Vet Med Surg (Small Anim), 1(2):172-175, 1986.
14. Wortman, JA: Principles of X Ray Computed Tomography and Magnetic Resonance Imaging. Semin Vet Med Surg (Small Anim), l(2):176-184, 1986.
15. Lichtensteiger, CA, Wortman, JA, Eigenmann, JE: Functional Pituitary Acidophil Adenoma in a Cat with Diabetes Mellitus and Acromegalic Features. Vet Pathol, 23(4):518-521, 1986.
16. Emms, SG, Wortman, JA, Johnston, DE, Goldschmidt, MH: Evaluation of Canine Hyper¬adrenocorticism using Computed Tomography. JAVMA, 189(4):432-439, 1986.
17. Saik, JE, Diters, RW, Wortman, JA: Metastasis of a Well Dif¬ferentiated Liposarcoma in a Dog and a Note on Nomenclature of Fatty Tumours. J Comp Pathol, 97(3):369-373, 1987.
18. Wortman, JA, Chang-Winterkorn, P, Knight, DH, Jacobs, GJ: Receiver Operating Characteristic Curve Analysis of the Utility of Thoracic Radiographs for the Diagnosis of Feline Cardiac Disease. Veterinary Radiology, 28(4):121-126, 1987.
19. Wood, AKW, Kundel, HL, McGrath, JT, Wortman, JA: CT, MRI and Pathologic Observations of the Effects of Intrathecal Metrizamide and Iohexol on the Canine Central Nervous System. Investigative Radiology, 22:672-677, 1987.
20. Wortman, JA, Alavi A, Attie, M, Yudd AP, Johnston, S, Greenberg, J: Quantitative Autoradiography of Parathy¬roid Glands in Rats with Carbon 14-Labeled Amino Acids. J Nucl Med, 28:1447-1452, 1987.
21. Schelling, CG, Wortman, JA, Saunders, HM: Ultrasonographic Detection of Splenic Necrosis in the Dog: Three Case Reports of Splenic Necrosis Secondary to Infarct¬ion. Veterinary Radiology, 29(5):227-233, 1988.
22. Van Vechten, M, Goldschmidt, MH, Wortman, JA: Embryonal Rhabdomyosarcoma of the Urinary Bladder in Dogs. The Compendium on Continuing Education for the Practicing Veterinarian, 12(6):783-793, 1990.
23. Wortman, JA: Film/Screen Combinations for Fine Detail Radiography. Veterinary Medicine Report, 1:80-86, 1991.
24. Speciale, J, Van Winkle, TJ, Steinberg, SA, Wortman, JA: Computed Tomography in the Diagnosis of Focal Granulomatous Meningoencephalitis: Retrospective Evaluation of Three Cases. JAAHA, 28(4):327-332, 1992.
25. Sheridan, O, Wortman, J, Harvey C, Hayden, J, Haskins, M: Craniofacial Abnormalities in Animal Models of Mucopolysaccharidoses I, VI, and VII. J Craniofac Genet Dev Biol, 14:7-15, 1994.
26. Mansfield, LS, Alavi, A, Wortman, JA, Schad, GA: Gamma Camera Scintigraphy for Direct Visualization of Larval Migration in Strongyloides stercoralis - Infected Dogs. Am J Trop Med Hyg, 52(3):236-240, 1995.
27. Pugh, CR, Wortman, JA, Lloyd, JKF, Saunders, HM, Biery, DN, Rhodes, WH, Evans, SM, Walker, LM, Green, P, Mendez-Aguillar, R, Regan, J: Comparative Evaluation of an Ultraviolet and an Orthochromatic Rare-Earth Imaging System for Veterinary Radiography. Vet Radiol & Ultrasound 36(6):485-492, 1995.
28. O'Brien, RT, Evans, SM, Wortman, JA, Hendrick, MJ: The Radiographic Findings in Cats with Intranasal Neoplasia or Chronic Rhinitis:29 Cases (1982-1988). JAVMA 208(3):385-389, 1996.
29. Shiue, CY, Shiue, GG, Zhang, SX, Wilder, S, Greenberg, J, Benard, F, Wortman, JA, Alavi, A: N-(N-Benzylpiperidin-4-yl)-2-[18F]fluorobenzamide: A Potential Ligand for PET Imaging of Sigma Receptors. Nucl Med & Biol 24(7) 671-676, 1997.
30. Saunders, HM, Burns, PN, Needleman, L, Liu, J-B, Boston, R, Wortman, JA, Chan, L: Hemodynamic Factors Affecting Uterine Artery Doppler Waveform Pulsatility in Sheep. J Ultrasound Med 17(6):357-368,1998.
31. Wortman, JA, Cesano, A, Pourdehnad, M, Visonneau, S, Mozley, D, Bhatnagar, A, Alavi, A, Santoli, D: Effects of Development of Host Immunity on the Biodistribution of Xenogeneic MHC Non-restricted Cytotoxic T Cells:Implications for Adoptive Cell Therapy of Cancer. Intl J Oncol, 14(2):233-244, 1999.
32. Reynolds, CH, Annan, N, Beshah, K, Huber, JH, Shaber, SH, Lenkinski, RE, Wortman, JA: Gadolinium-Loaded Nanoparticles: New Contrast Agents for Magnetic Resonance Imaging. J Am Chem Soc 122(37):8940-8945, 2000.
33. Davis, GJ, Kapatkin AS, Craig, LE, Heins, GS, Wortman, JA: Comparison of Radiography, Computed Tomography and Magnetic Resonance Imaging for Evaluation of Appendicular Osteosarcoma in Dogs. JAVMA 220(8):1171-1176, 2002.
34. Mayhew, PD, Kapatkin, AS, Wortman, JA, Vite, CH: Association of Cauda Equina Compression on Magnetic Resonance Images and Clinical Signs in Dogs with Degenerative Lumbosacral Stenosis. J Am Anim Hosp Assoc 38(6):555-562, 2002.

 

Micro-tumor perfusion evaluated with Power Doppler in a Murine model (Image courtesy of Dr Gabriela Seiler)

JENNIFER ADOLF REETZ, DVM, DACVR, DACVIM, STAFF VETERINARIAN IN RADIOLOGY

1. Adolf JA, Perkins G, Ainsworth DM, de Lahunta A. Lymphoma of the central nervous system in horses. Compend Contin Educ Pract Vet 2001; 23:194-202.
2. Adolf JA, Dykes NL, Semevolos S, Divers TJ. The diagnosis and treatment of a thoracic abscess in an alpaca. Aust Vet J, 2001; 79:675-679.
3. Adolf JA, Divers TJ, Fortier LA, Bernard WV. Hepatic diseases in foals. In: Mair T, Divers TJ, Ducharme N, eds. Manual of Equine Gastroenterology. WB Saunders Co, London, 2002, pp. 513-525.
4. Reetz JA, Seiler G, Mayhew PD, Holt DE. Ultrasonographic and color-flow Doppler ultrasonographic assessment of direct cutaneous arteries used for axial pattern skin flaps in dogs. JAVMA 2006; 228:1361-1365.
5. Reetz JA, Mai W, Muravnick KB, Goldschmidt MH, Schwarz T. Computed Tomographic evaluation of anatomic and pathologic variations in the feline nasal septum and paranasal sinuses. Vet Radiol Ultrasound 2006; 47(4):321-327.
6. Morgan O.D.E, Reetz J.A., Brown D.C., Tucker S.M., Mayhew P.D. Complication rate, outcome and risk factors associated with surgical repair of fractures of the lateral aspect of the humeral condyle in dogs. VCOT 2008 (In Press).

ANA CACERES, DVM, DACVR, STAFF VETERINARIAN IN RADIOLOGY

1. Patel, RT, Cáceres A, French AF, McMannus PM. Multiple Myeloma in sixteen cats: a retrospective study. Veterinary Clinical Pathology, 2005; 34(4):341-52.
2. Cáceres A, Zwingenberger A, Hardam E, Lucena J, Schwarz T. Helical CT angiography of the normal canine pancreas. Vet Radiol Ultrasound, 2006; 47(3):270-278.
3. Kinns J., Mai W., Seiler G., Zwingerberger A., Johnson V., Cáceres A., Valdes-Martinez A., Schwarz T., Radiographic sensitivity and negative predictive value for acute canine spinal trauma. Vet Radiol Ultrasound, 2006; 47(6): 563-570.
4. Mai W., Cáceres A.V. "Dual-phase computed tomographic angiography in three dogs with pancreatic insulinoma." Vet Radiol Ultrasound. 2008; 49:141-148.
5. Cáceres A.V., Zwingenberger A.L., Aronson L.R., Mai W. "Characterization of normal feline renal vascular anatomy with dual-phase CT angiography." Vet Radiol Ultrasound. 2008; 49:350-356.

YAEL PORAT-MOSENCO, DVM, DECVDI, DACVR, STAFF VETERINARIAN IN RADIOLOGY

1. Porat-Mosenco Y., Schwarz T. and Kass P.H.: Thick-Section Reformatting of Thinly Collimated Computed Tomography for Reduction of Skull-Base Related Artifacts in Dogs and Horses. Vet Radiol Ultrasound. 2004; 45(2):131-5.
2. Berent A., Mayhew P.D., Porat-Mosenco Y.: Use of cystoscopic-guided laser ablation for treatment of intramural ureteral ectopia in male dogs: four cases (2006-2007). JAVMA. 2008; 232(7):1026-1034.