The P3VMS (Penn-Pitt Partnership in Veterinary Medical Science) Summer Research Program is designed to expose students in their first or second year of veterinary school to all phases of biomedical research, particularly those involving primate studies at the University of Pittsburgh.
This includes the development of research ideas, the preparation of research proposals, the performance of biomedical research, and the presentation of research results in written and oral formats. Students in the program perform full time biomedical research during the months of June, July, and August, participate in weekly seminars, and present their work in oral, poster, and written presentations.
The program provides a rich experience in biomedical research for students and simultaneously exposes them to a wide variety of research topics through seminars. Students also benefit from close association with University faculty who might become your advisor in an established PhD program. The University of Pittsburgh currently ranks 5th among universities in the nation with federally funded NIH grants.
Who Is Eligible?
Any veterinary student who has completed one semester of veterinary school is eligible to apply. Students are solely from the University of Pennsylvania.
Assistance with identifying low cost housing, and a $5,000 stipend and $500 relocation allowance are provided by the University of Pittsburgh. Available Laboratories All of the laboratories at the University of Pittsburgh Schools of Health Sciences are potentially available (with approval).
The following laboratories have been selected and agreed to be host laboratories with a deep interest in veterinary students from the University of Pennsylvania:
Peter L. Strick, PhD:
- Dr. Strick is the Chair of Neurobiology, Director of the Systems Neuroscience Institute, and Co-Director of the CNUP and CNBC. He is a world’s expert in mapping neurons in the CNS using herpes virus and recently elected member of the National Academy of Sciences. Strick's research focuses on four major issues: motor learning and the control of voluntary movement by the motor areas of the cerebral cortex; the motor and cognitive functions of the basal ganglia and cerebellum; the neural basis for the mind-body connection; and unraveling the complex neural networks that comprise the central nervous system.
- Please contact him at 412-383-9961 or firstname.lastname@example.org .
Joanne Flynn, PhD:
- Their lab studies the pathogenesis of Mycobacterium tuberculosis, the causative agent of tuberculosis. Tuberculosis kills about 2 million people every year worldwide. After a century of study of this organism, we still do not understand many basic mechanisms by which it causes disease, and how to protect against it. Their lab focuses on the host-pathogen interactions and immunology of M. tuberculosis, with the majority of studies in non-human primate models. They have pioneered the use of the cynomolgus macaque for basic biology, immunology, and pathogenesis, drug and vaccine studies, and have incorporated state-of-the-art immunologic techniques and serial imaging (PET/CT) into our studies. They also use a small new world monkey, the common marmoset, for studies of transmission of infection. They benchmark our studies against the human data obtained from collaborators. The non-human primate models of tuberculosis we have developed and used are extremely similar to tuberculosis in humans. We work closely with pathologists, veterinarians, microbiologists, immunologists and drug and vaccine experts in developing the models as well as using these models in translational studies. At the University of Pittsburgh, they have outstanding and unparalleled BSL3 facilities for studying TB in monkeys, including PET/CT imaging in the BSL3.
- Contact Dr. Flynn at 412-624-7743 or email@example.com
Simon Barratt-Boyes, BVSc, PhD, Dip ACVIM:
- Defining dendritic cells and macrophages in HIV/AIDS pathogenesis using the simian immunodeficiency virus (SIV) model Mononuclear phagocytes are important innate immune cells that include monocytes, macrophages, and dendritic cells (DCs), which in the human and nonhuman primate consist of two major subsets, myeloid and plasmacytoid. Given their function in antiviral immunity, dendritic cells are thought to play a protective role in HIV and SIV infection, and loss of both subsets is associated with disease progression. However, recently emphasis has been placed on the potential role of the innate immune response in chronic, generalized immune activation that is a hallmark of AIDS. In this scenario, over-active mononuclear phagocytes produce pro-inflammatory cytokines that drive chronic interferon production and inflammation in lymphoid and gut tissues. Hence there is a basic unanswered question in HIV pathogenesis: are DCs, monocytes and macrophages beneficial or detrimental to the infected host? We use the model of SIV infection of rhesus macaques, which replicates the pathogenesis of HIV-1 infection in humans and leads to simian AIDS, to address this question.
- Contact Dr. Barratt-Boyes at firstname.lastname@example.org or 412 383 7537.
J. Timothy Greenamyre, MD, PhD:
- The lab is interested in mechanisms of neurological disease and neurodegeneration in general, and focuses primarily on Parkinson’s disease and epilepsy. We are particularly interested in mitochondrial impairment, oxidative mechanisms and inflammation in the brain. In addition to defining pathogenic mechanisms, the lab is working to develop new therapeutic approaches including gene therapies. We use a wide variety of in vitro and in vivo models, and techniques range from molecular biology to behavior. Contact Dr. Greenamyre at email@example.com or 412-648-9793. Bennett Van Houten, PhD: His lab studies the formation and repair of DNA damage in nuclear and mitochondrial genomes with particular interest in the structure and function of proteins that mediate nucleotide excision repair and the role of oxidative stress in human disease; Understanding the structure and function of nucleotide excision Repair (NER) proteins, both in bacteria and in humans; Solving protein and protein-DNA structures by X-ray crystallography; Visualizing NER on DNA using single-molecule techniques, including atomic force microscopy and fluorescence microscopy using quantum dot labeling; Investigating tumor cell bioenergetics and potential strategies for therapeutic intervention.
- Contact Dr. Van Houten at 412-623-7762 or firstname.lastname@example.org.
Michael T. Lotze, MD:
- The DAMP Laboratories of the University of Pittsburgh were formed in 2006 to focus on the role of Damage Associated Molecular Pattern Molecules [DAMPs], released or secreted by damaged or injured cells or the inflammatory cells responding to the "danger". Initiated as a coalition of the laboratories headed up by Drs. Liang, Lotze, Tang and Zeh, they focus on the critical role of DAMPs in the initiation of chronic inflammation and the disease that often eventuates as a consequence, cancer. Many local and international collaborators are working with this group to evaluate the role of DAMPs in cancer. They are located in the G.27 Hillman Cancer Center and span fundamental studies related to the role of DAMPs and their receptors [DAMP-R] in cancer pathogenesis and persistence in transgenic and transplantable murine tumor models, closely linked with the clinical efforts to limit necrotic cell death and promote normal, and programmed [apoptotic] cell death.
- Contact Dr. Lotze at email@example.com or 412-623-6790
Patrick Moore MD and Yuan Chang MD:
- The Chang-Moore lab <tumorvirology.pitt.edu> in the Cancer Virology Program focuses on carcinogenic human herpesviruses and polyomaviruses. Our laboratory discovered the two most recent human tumor viruses, KSHV and MCV, causing Kaposi's sarcoma and Merkel cell carcinoma, respectively. Current projects involve basic investigations into how these viruses induce cell transformation. For MCV, we are focused on examining the role of large T antigen in inducing the cellular oncoprotein survivin and on examining the role of small T antigen in regulating cap-dependent protein translation. We are generating a conditionally-expressed small T antigen mouse as a potential model for Merkel cell carcinogenesis. For KSHV, we have lately been concentrating on understanding non-canonical translation proteins expressed from the LANA1 locus, and identifying unique cellular interactors with non-canonical LANA1 proteins.
- Contact Dr. Moore (firstname.lastname@example.org ) or Dr. Chang (email@example.com) or call 412-623-7721.
Carolyn B. Coyne, PhD:
- Dr. Coyne’s research employs aspects of cell biology, immunology, and microbiology to study multiple aspects of host-pathogen interactions. Their studies primarily focus on: (1) the identification of novel host cell innate immune molecules and pathways that regulate antiviral signaling, (2) the viral factors that attenuate host antiviral signals, and (3) the mechanisms employed by human placental trophoblasts to combat microbial access to the fetal compartment. Through these studies, they found that primate-specific microRNAs (miRNAs) that are produced almost exclusively by placental trophoblasts are secreted via exosomes and mediate protection from viral infections. They are currently dissecting the molecular basis for this protection and developing systems to study the role of these miRNAs in viral protection in vivo.
- Contact Carolyn Coyne at firstname.lastname@example.org or 412-383-5149.
Karen A. Norris, PhD and Mark T. Gladwin, MD:
- Dr. Norris is a Professor of Immunology and the Director of Basic Sciences in the HIV Lung Research Center. Dr. Norris conducts research in immunology and infectious diseases with emphasis on cardiopulmonary complications of HIV infection, chronic obstructive pulmonary disease and pulmonary hypertension. Dr. Norris’ research efforts are focused on non-human primate (NHP) models of HIV infection and pulmonary disease. She works with a team of investigators and collaborators who provide expertise in all aspects of these studies including veterinary, pulmonary, cardiology, pathology, immunology, radiology, virology, morphometric analyses and immunology. This team has been successful in establishing the first primate model of Pneumocystis infection and she has established that SIV-associated COPD is dependent upon Pneumocystis colonization. Recent research efforts involve the development and evaluation primate models of pulmonary arterial hypertension, immune-mediated lung pathology and Pneumocystis vaccine development. Dr. Norris is highly committed to integrated studies of complex biomedical problems utilizing non-human primate models and establishing multidisciplinary, collaborative research teams to accomplish these goals.
- Contact Dr. Karen Norris at email@example.com or 412 648-8848.
Timothy R. Billiar, MD:
- Researchers in the general surgery and vascular labs are asking (and answering) some fundamental questions about how the immune system responds to cell damage. Why do some people get multiple organ failure after trauma, while others recover without complication? Why do vascular grafts fail? How does inflammation in cells and tissues of major organs affect immune responses? Can we predict how well individual patients will recover from surgery and trauma? Cell damage occurs in many situations, such as following surgery or surgical procedures, after trauma (including bone fractures) or during infection. Limiting harmful inflammation may help patients to recover from injury more quickly, and with fewer complications. Extensive mouse colonies with floxed alleles of HMGB1, TLRs, caspase 1, and others are important to the work of the group.
- Contact Dr. Billiar at firstname.lastname@example.org or 412-647-1749. Application to the Program
Apply now to the P3VMS Research Training Program
To apply to the program, students interested in performing biomedical research discuss research ideas with participating faculty. All faculty members at the University of Pittsburgh are eligible (with approval) to accept a student in the program, thus students are not restricted to the participating faculty list. University of Pittsburgh Office of the Senior Vice Chancellor for the Health Sciences Scaife Hall Suite 401, 3550 Terrace Street Pittsburgh, PA 15261
• Email: email@example.com General Inquiries: 412-383-7765 The Program Co-Directors, Drs. Michael Atchison and Michael Lotze, can assist students in identifying faculty with interests compatible with theirs, or students can identify a faculty mentor through information available at the various Pitt graduate group web pages, and departmental web pages.
• The student and faculty mentor fill out an application package and write a short research proposal (approximately 3 pages) which is due February 14th this year.
• Please make sure to contact possible faculty mentors as soon as possible. The research proposal should define the questions being pursued and should explain the experimental approaches to be taken to answer those questions.
• The advisory committee reviews the applications with respect to academic standing of the student, quality of the research proposal, and training potential of the mentor's laboratory. Students whose applications are funded are notified by mid March of their award.
• Please contact Megan Seippel for questions.
• Megan Seippel, MPA Program Administrator University of Pittsburgh Cancer Institute 5150 Centre Avenue UPMC Cancer Pavillion, Room 405 Pittsburgh, PA 15232 Phone: 412-623-5977 Email: firstname.lastname@example.org
• Michael T. Lotze, MD Program Director Professor of Surgery, Immunology, and Bioengineering UPCI, Hillman Cancer Center 5117 Centre Avenue, Suite G.27A Phone: 412-623-6790 Email: email@example.com
Expand Your Range of Research Skills
If you are interested in engaging in groundbreaking research in addition to pursuing your VMD, or if you are an intern, resident, or post-doctoral student interested in expanding your current scope of capabilities, Penn Vet offers a unique combination of opportunities:
- Penn-Pitt Partnership
- NIH/Merial Summer Research Program
- Merial Veterinary Scholars & Other Programs
- Biomed Post-Doc Programs
- Graduate Groups
- Training Grants
- Clinical Research Training