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  Faculty
Margret Casal
Assistant Professor of Medical Genetics

Department of Clinical Studies -Philadelphia
3900 Delancey Street
School of Veterinary Medicine
University of Pennsylvania
Philadelphia, PA   19104-6010
Qualifications

-Veterinary Degree, University of Zürich, Switzerland
-Doctorate in Virology (Master’s equivalent), University of Bern, Switzerland
-PhD, University of Pennsylvania
-Diplamate, European College of Animal Reproduction

Memberships

-Phi Zeta
-AVMA
-European College of Animal Reproduction

Clinical Interests
Genetic and Pediatric Diseases of Dogs and Cats, Small Animal Reproduction
Research Interests

-Genodermatoses (Inherited Skin Disorders)
-Collagen Defects (Osteogenesis imperfecta)
-Wolfhound Rhinitis and Epilepsy in the Irish Wolfhound
Selected Publications

Casal ML, Dambach DM, Meister T, Jezyk PF, Patterson DF, Henthorn PS. (2004)
Familial glomerulonephropathy in the bullmastiff. Vet Pathol. 41(4):319-25.

Casal ML, Wolfe JH. (2001) In utero transplantation of fetal liver cells in the mucopolysaccharidosis type VII mouse results in low-level chimerism, but overexpression of beta-glucuronidase can delay onset of clinical signs. Blood. 97(6):1625-34.

Henthorn PS, Liu J, Gidalevich T, Fang J, Casal ML, Patterson DF, Giger U. (2000) Canine cystinuria: polymorphism in the canine SLC3A1 gene and identification of a nonsense mutation in cystinuric Newfoundland dogs. Hum Genet. 107(4):295-303.

Sammarco C, Weil M, Just C, Weimelt S, Hasson C, O'Malley T, Evans SM, Wang P, Casal ML, Wolfe J, Haskins M. (2000) Effects of bone marrow transplantation on the cardiovascular abnormalities in canine mucopolysaccharidosis VII. Bone Marrow Transplant. 25(12):1289-97.

Casal ML, Wolfe JH. (2000) Mucopolysaccharidosis type VII in the developing mouse fetus. Pediatr Res. 47(6):750-6.

Casal ML, Wolfe JH. (1998) Variant clinical course of mucopolysaccharidosis type VII in two groups of mice carrying the same mutation. Lav Invest. 78(12):1575-81.

Casal ML, Jezyk PF, Greek JM, Goldschmidt MH, Patterson DF. (1997) X-linked extodermal dysplasia in the dog. J Hered. 88(6):513-7.

Giger U, Casal ML. (1997) Feline colostrum -- friend of foe: maternal antibodies in queens and kittens. J Reprod Fertil Suppl. 51:313-6.

Casal ML, Wolfe JH. (1997) Amphoteric and ecotropic retroviral vector viruses transduce midgestrational murine fetal liver cells in a dual-chambered cocultivation system. Gene Ther. 4(1):39-44.

Casal ML, Jezyk PF, Giger U. (1996) Transfer of colostral antibodies from queens to their kittens. Am J Vet Res. 57(11):1653-8.

Griot-Wenk ME, Callan MB, Casal ML, Chisholm-Chait A, Spitalnik SL, Patterson DF, Giger U. (1996) Blood type AB in the feline AB blood group system. Am J Vet Res. 57(10):1438-42.

Casal ML, Giger U, Bovee KC, Patterson DF. (1995) Inheritance of cystinuria and renal defect in Newfoundlands. J Am Vet Med Assoc. 207(12):1585-9.

Somber RL, Pullen RP, Casal ML, Patterson DF, Felsburg PJ, Henthorn PS. (1995) A single nucleotide insertion in the canine interleukin-2 receptor gamma chain results in X-linked sever combined immunodeficiency disease. Vet Immunol Immunopathol. 47(3-4):203-13.

A. Lupoid Dermatosis
B. Black Hair Follicular Dysplasia
C. Ichthyosis (Porokeratosis of Mibelli)
D. X-linked Ectodermal Dysplasia