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| Research Interests |
| This laboratory studies the events that regulate protective immunity to the parasite Toxoplasma gondii. Molecular and cellular techniques are used to understand how Natural Killer and T cell responses are co-ordinated by cytokines and costimulatory molecules to develop an integrated protective immune response without the development of immunopathology. |
| Selected Publications : Search PubMed for articles |
| Shibuya, K., Robinson, D., Zonin, D., Hartley, S., Macatonia, S.E., Somoza, C., Hunter, C.A. , Murphy, K.M., O'Garra, A. (1998). IL-1a and TNF-a are required for IL-12 induced development of Th1 cells producing high levels of interefron-g in BALB/c but not C57BL/6 mice. Journal Immunology160:1708-1716.
Bohne, W., Hunter, C.A. , White, M.W., Ferguson, D.J.P., Gross, U. and Roos, D.S. (1998). Targeted disruption of the bradyzoite-specific gene bag1does not prevent tissue cyst formation in Toxoplasma gondii. Molecular Biochemical Parasitology 92: 291-301. Coughlin, C.M., Salhany, K.E., Wysocka, M., Aruga, E., Kurzawa, H., Chang, A.E., Hunter, C.A. , Fox, J.C., Trinchieri, G., and Lee, W.M.F. (1998). Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. Journal Clinical Investigation 101:1441-1452. Kurzawa, H., Hunter, C.A. , Wysocka, M., Trinchieri, G., and Lee. W.M.F. (1998). Immune suppression by recombinant IL-12 involves IFNg induction of nitric oxide synthase 2 (iNOS) activity: Inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect. Journal Experimental Medicine 188:1603-1610. Hodge-Dufour, J., Marino, M.W., Horton, M.R., Jungbluth, A., Burdick, M.D., Strieter, R.M., Noble, P.W., Hunter, C.A. , and PurÈ, E. (1998). Inhibition of interferon induced interleukin 12 production: A potential mechanism for the anti-inflammatory activities of tumor necrosis factor. Proceedings National Academy Sciences (USA) 95:13806-13811. Li, J., Hunter, C.A. , and Farrell, J.P. (1999). Anti-TGF-b treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production. Journal Immunology 162:974-979 Walker, W., Aste-Amezaga, M., Kastelein, R.A., Trinchieri, G., and Hunter, C.A. (1999). Interleukin (IL)-18 and CD28 uses distinct molecular mechanisms to enhance natural killer cell production of IL-12-induced interferon-gamma. Journal of Immunology 162: 5894-5901. Alexander, J. and Hunter, C.A (1998) Immunoregulation during Toxoplasmosis. Chemical Immunology 70: 81-104 (In Immunology of Intracellular Parasites, Editors F.Y.Liew and F.E.G. Cox). Villegas, E.N., Wille, U., Craig, L., Linsley, P.S., Rennick, D.M., Peach, R., Hunter, C.A. (2000). Blockade of costimulation prevents infection-induced immunopathology in Reichmann, G., Walker, W., Villegas, E.N., Craig, L., Cai, G., Alexander, J., Hunter, C.A. (2000) The CD40/CD40L interaction is required for resistance to toxoplasmic Cai, G., Radzanowski, T., Villegas, E., Kastelein, R.A., Hunter, C.A. (2000). Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma Cai, G., Kastelein, R.A., Hunter, C.A. (2000). Interleukin 18 enhances innate IL-12-mediated resistance to Toxoplasma gondii. Infection and Immunity 68:6932-6938. Blass, S.L., Pure, E., Hunter, C.A. (2001). A role for CD44 in the production of IFN-g and immunopathology during toxoplasmosis. Journal of Immunology 166: 5726-5733. Hunter, C.A. , D.Yu, M.Gee, C.Ngo, C.Sevignani, S.Evans, T. Golovkina, Villarino, A., Planz, L., Lieberman, L., Wilson, E., Yoshida, H., Mak, T., Kastelein, R., Saris, C. and Hunter, C.A. (2003). The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19: 645-655. Pearce, E. L, Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C. A., Shen, H., Cereb, N., Yang, S. Y., Lindsten, T., Rossant, J., Hunter, C. A., Reiner, S. L. (2003). Control of effector CD8+ T cell function by the transcription factor Eomesodermin, Science 302: 1041-3 Mason, N.J.. Liou, H.C., Hunter, C.A. (2004). C-Rel plays a critical role in the regulation of T cell responses required for resistance to toxoplasmic encephalitis. Journal Immunology 172: 3704-3711 Tato, C.M., G. Martins, F.A. High, K. DiCoco, S.L. Reiner and C.A. Hunter. (2004) Cutting Edge: Early production of IFN-$B&C(B by NK cells is independent of epigenetic modification of the IFN-$B&C(B promoter. Journal Immunology 173:1514-1518. Lieberman, L., Cardillo, F., Cua,D., Rennick, D., Kastelein, R., Hunter, C.A. (2004). IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12 Journal Immunology 173:1887-1893. Artis, D.; Villarino, A.; Silverman, M.; He, W.; Thornton, E.M; Mu, S.; Summer, S.; Covey, T.; Huang, E.; Yoshida, H.; Koretzky, G.; Goldschmidt, M.; Wu, G.D.; de Sauvage, F.; Millar, H.R.P.; Saris, C.; Scott, P.; Hunter, C.A. 2004. The IL-27R (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. Journal Immunology 173: 5626-34. Pepper, M., Dzierszinski, F., Hunter, CA., Roos, D. (2004). Development of a system to study CD4+-T-cell responses to transgenic ovalbumin-expressing Toxoplasma gondii during toxoplasmosis. Infection and Immunity 72: 7240-6.
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| Graduate Groups |
Immunology Parsitology |
| Graduate Students |
| Guifang Cai, (1996-present, Parasitology). Eric Villegas, (1996-present, Parasitology). Sarah Blass, (1997-present, Immunology). Christina Tato (1999, Immunology). |
| Postdocs and Fellowships |
| William Walker 1996-present Jorge Cammano 1998-present Ulrike Wille 1998-present |
