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| Research Interests |
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| Our research centers on the identification of factors that regulate susceptibility versus resistance in mice infected with the protozoan parasites, Leishmania major and Leishmania donovani. With respect to L. major, our current interest is how uptake of parasites via Fc gamma receptors regulates the production of factors such as IL-10, and TGF- We have shown that normally susceptible strains of mice lacking Fc gamma receptors can control infection and that healing correlates with reduced production of IL-10 production by parasitized macrophages. We are now investigating how different antibody isotypes and different Fc gamma receptors interact to elicit production of this anti-inflammatory cytokine. Our lab also studies the regulation of effector cell responses in mice with visceral leishmaniasis. Most recently, we have focused on the role of the costimulatory molecule, CD28, and the cytokine, IL-10, regulate resistance to L. donovani. Our ultimate goal is to understand the basic mechanisms by which cell receptors and cytokines regulate T cell responses and immunity to leishmaniasis. |
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| Selected Publications |
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| Li, J., P. Scott, and J.P. Farrell. 1996. In vivo alterations in cytokine production following interleukin-12 (IL-12) and anti-IL-4 antibody treatment of CB6F1mice with chronic cutaneous leishmaniasis. Infection and Immunity 62: 5248-5254.
Li, J., T.J.Nolan, and J.P. Farrell. 1997. Leishmania major: A clone with low virulence for BALB/c mice elicits a Th1 type response and protects against infection with a highly virulent clone. Exp. Parasitol. Experimental Parasitology 87:47-57. Li, J., S. Sutterwala, and J.P. Farrell. 1997. Successful therapy of chronic, nonhealing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production. Infection and Immunity 65:3225-3230. Scott, P. and J.P. Farrell. 1998. Experimental Cutaneous Leishmaniasis: Induction and regulation of T cells Following Infection with Leishmania major. Li, J., C.A. Hunter and J.P. Farrell. 1999. Anti-TGF-b treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production. J. Immunol.162:974-979. Li, J., C.A. Hunter and J.P. Farrell. 1999. Anti-TGF-ß treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production. J. Immunol.162:974-979. Murphy, M.L., Wille, U., Villegas, E.N., Hunter, C.A., and J.P. Farrell. 2001. IL-10 mediates susceptibility to Leishmania donovani infection. Eur. J. Immunol. 31: 2848-2856, 2001 U. M. Padigel, P. Perrin and J.P.Farrell. The development of a Th1 Type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulation. J Immunol.167: 5874-5879. Compton, H.L, and J.P. Farrell CD28 costimulation and parasite dose combine to influence the susceptibility of BALB/c mice to infection with Leishmania major J. Immumol. 168:1302-1308, 2002 Li, J., U.M. Padigel, P. Scott and J.P. Farrell. Combined treatment with IL-12 and indomethacin promotes increased resistance in BALB/c mice with established Leishmania major infections. Infection and Immunity. 70: 5715-5720, 2002. Padigel U.M. and J.P. Farrell. CD40-CD40 ligand costimulation is not required for initiation and maintenance of a Th1-type response to Leishmania major infection. Infect Immun. 71:1389-1395, 2003. Padigel, U.M., J.Alexander and J.P. Farrell The role of interleukin-10 in susceptibility of BALB/c mice to infection with Leishmania mexicana and Leishmania amazonensis. J Immunol. 171:3705-10., 2003 Padigel, U.M., N.Kim, Y. Choi, and J.P. Farrell. TRANCE-RANK costimulation is required for IL-12 production and the initiation of a Th1-type response to Leishmania major infection in CD40L deficient mice. J. Immunol. 171: 5437-1541. 2003 Padigel U.M. and J.P. Farrell. Control of infection with Leishmania major in susceptible BALB/c mice lacking the common {gamma}-chain for FcR is associated with reduced production of IL-10 and TGF-{beta} by parasitized cells. J Immunol. 174:6340-6345. 2005 |
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| Graduate Groups |
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Immunology Parasitology |
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| Postdocs and Fellowships |
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| Udai Padigel, Ph.D. Muniraj Manohar, Ph. D |
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