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  Faculty
Peter J. Felsburg V.M.D., Ph.D.
Trustee Professor of Clinical Immunology

Department of Clinical Studies -Philadelphia
3900 Delancey Street
School of Veterinary Medicine
University of Pennsylvania
Philadelphia, PA   19104-6010
Qualifications

-VMD, University of Pennsylvania
-Ph.D., University of Pennsylvania

Clinical Interests
Clinical Immunology
Research Interests
Hereditary immunodeficiencies, SCID, gene therapy
Selected Publications
Suter SE, Gouthro TA, McSweeney PA, Nash RA, Haskins ME, Felsburg PJ, Henthorn PS. (2004) Isolation and characterization of pediatric canine bone marrow CD34(+) cells. Vet Immunol Immunopathol. 101(1-2):31-47.

Cruickshank SM, McVay LD, Baumgart DC, Felsburg PJ, Carding SR. (2004) Colonic epithelial cell mediated suppression of CD4 T c

Suter SE, Gouthro TA, McSweeney PA, Nash RA, Haskins ME, Felsburg PJ, Henthorn PS. (2004) Isolation and characterization of pediatric canine bone marrow CD34(+) cells. Vet Immunol Immunopathol. 101(1-2):31-47.

Cruickshank SM, McVay LD, Baumgart DC, Felsburg PJ, Carding SR. (2004) Colonic epithelial cell mediated suppression of CD4 T cell activation. Gut. 53(5):678-84.

Ashcroft AJ, Cruickshank SM, Croucher PI, Perry MJ, Rollinson S, Lippitt JM, Child JA, Dunstan C, Felsburg PJ, Morgan GJ, Carding SR. (2003) Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin. Immunity. 19(6):849-61.

Felsburg PJ, Hartnett BJ, Gouthro TA, Henthorn PS. (2003) Thymopoiesis and T cell development in common gamma chain-deficient dogs. Immunol Res. 27(2-3):235-46.

Felsburg PJ. (2002) Overview of immune system development in the dog: comparison with humans. Hum Exp Toxicol. 21(9-10):487-92.

Hartnett BJ, Yao D, Suter SE, Ellinwood NM, Henthorn PS, Moore PE, McSweeney PA, Nash RA, Brown JD, Weinberg KI, Felsburg PJ. (2002) Transplantation of X-linked severe combined immunodeficient dogs with CD34+ bone marrow cells. Biol Blood Marrow Transplant. 8(4):188-97.

Morris DO, Clayton DJ, Drobatz KJ, Felsburg PJ. (2002) Response to Malassezia pachydermatis by peripheral blood mononuclear cells from clinically normal and atopic dogs. Am J Vet Res. 63(3):358-62.

Hartnett BJ, Somberg RL, Krakowka S, Ochs HD, HogenEsch H, Moore PF, Weinberg KI, Felsburg PJ. (2000) B-cell function in canine X-linked severe combined immunodeficiency. Vet Immunol Immunopathol. 75(1-2):121-34.

Hartnett BJ, Henthorn PS, Moore PF, Weinberg KI, Ochs HD, Felsburg PJ. (1999) Bone marrow transplantation for canine X-linked severe combined immunodeficiency. Vet Immunol Immunopathol. 69(2-4):137-44.

Felsburg PJ, Hartnett BJ, Henthorn PS, Moore PF, Krakowka S, Ochs HD. (1999) Canine X-linked severe combined immunodeficiency. Vet Immunol Immunopathol. 69(2-4):127-35.

Felsburg PJ, Somberg RL, Hartnett BJ, Henthorn PS, Carding SR. (1998) Canine X-linked severe combined immunodeficiency. A model for investigating the requirement for the common gamma chain (gamma c) in human lymphocyte development and function. Immunol Res. 17(1-2):63-73.

Pullen RP, Somberg RL, Felsburg PJ, Henthorn PS. (1997) X-linked severe combined immunodeficiency in a family of Cardigan Welsh corgis. J Am Anim Hosp Assoc. 33(6):494-9.

Felsburg PJ, Somberg RL, Hartnett BJ, Suter SF, Henthorn PS, Moore PF, Weinberg KI, Ochs HD. (1997) Full immunologic reconstitution following nonconditioned bone marrow transplantation for canine X-linked severe combined immunodeficiency. Blood. 90(8):3214-21.

Somberg RL, Tipold A, Hartnett BJ, Moore PF, Henthorn PS, Felsburg PJ. (1996) Postnatal development of T cells in dogs with X-linked severe combined immunodeficiency.
J Immunol. 156(4):1431-5.

Hogenesch H, Snyder PW, Scott-Moncrieff JC, Glickman LT, Felsburg PJ. (1995) Interleukin-6 activity in dogs with juvenile polyarteritis syndrome: effect of corticosteroids. Clin Immunol Immunopathol. 77(1):107-10.

Somberg RL, Pullen RP, Casal ML, Patterson DF, Felsburg PJ, Henthorn PS. (1995) A single nucleotide insertion in the canine interleukin-2 receptor gamma chain results in X-linked severe combined immunodeficiency disease. Vet Immunol Immunopathol. 47(3-4):203-13.

Snyder PW, Kazacos EA, Scott-Moncrieff JC, HogenEsch H, Carlton WW, Glickman LT, Felsburg PJ. (1995) Pathologic features of naturally occurring juvenile polyarteritis in beagle dogs. Vet Pathol. 32(4):337-45.

Somberg RL, Robinson JP, Felsburg PJ. (1994) T lymphocyte development and function in dogs with X-linked severe combined immunodeficiency. J Immunol. 153(9):4006-15.

Henthorn PS, Somberg RL, Fimiani VM, Puck JM, Patterson DF, Felsburg PJ. (1994) IL-2R gamma gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease. Genomics. 23(1):69-74.

Deschenes SM, Puck JM, Dutra AS, Somberg RL, Felsburg PJ, Henthorn PS. (1994) Comparative mapping of canine and human proximal Xq and genetic analysis of canine X-linked severe combined immunodeficiency. Genomics. 23(1):62-8.