University of Pennsylvania: School of Veterinary Medicine

Mark E. Haskins V.M.D. , M.S. , Ph.D.

Professor of Pathology and Medical Genetics

Department of Clinical Studies -Philadelphia
310A Rosenthal
3800 Spruce Street
School of Veterinary Medicine
University of Pennsylvania
Philadelphia , PA 19104-6010

215.898.4852 Phone
215.898.0719 Fax
mhaskins@vet.upenn.edu Email

Qualifications

-VMD, University of Pennsylvania
-MS, Drexel University
-Ph.D., University of Pennsylvania

Clinical Interests

Genetic and Pediatric Diseases of Dogs and Cats

Research Interests

Lysosomal Storage Diseases, Gene Therapy
Referral Center for Animal Models of Human Genetic Disease

Selected Publications

Zhang, J., Xu, L., Haskins, M.E., Ponder, K.P. (2004) Neonatal gene transfer with a retroviral vector results in tolerance to human factor IX in mice and dogs. Blood 103:143-151.
Silverstein Dombrowski, D.C., Carmichael, K.P., Wang, P., O'Malley, T., Haskins, M.E., Giger, U. (2004) Mucopolysaccharidosis type VII in a German Shepherd Dog. JAVMA 224:553-557.

Ellinwood, N.M., Vite, C.H., and Haskins, M.E. (2004) Gene therapy for lysosomal storage diseases: The lessons and promise of animal models. J. Gene Medicine 6:481-506.
Mango, RL, Xu L, Sands, MS, Vogler, C, Seiler, G, Schwarz, T, Haskins, ME, Ponder, KP. (2004) Neonatal retroviral vector-mediated hepatic gene therapy reduces bone, joint, and cartilage disease in mucopolysaccharidosis VII mice and dogs. Mol Genet Metab, 82:4-19.

Sleeper, M.M., Fornasari, B., Ellinwood, N.M., Weil, M.A., Melniczek, J., O'Malley, T.M., Sammaroc, C.D., Xu, L., Ponder, K.P., and Haskins, M.E. (2004) Gene therapy ameliorates cardiovascular disease in dogs with mucopolysaccharidosis VII. Circulation 110:815-820.

Suter, S.E., Gouthro, T.A., McSweeney, P.A., Nash, R.A., Haskins, M.E., Felsburg, P.J., Henthorn, P.S. (2004) Isolation and characterization of pediatric canine bone marrow CD34+ cells. Vet. Immunol. and Immunopathology 101:31-47.

Xu, L., O'Malley, T., Sands, M.S., Wang, B., Meyerrose, T., Haskins, M., Ponder, K.P. (2004) In vivo transduction of hematopoietic stem cells after neonatal intravenous injection of an amphotropic retroviral vector in mice. Mol Therapy 10:37-44.

Tomatsu, S., Okamura, K., Maeda, H., et al (2004) Keratan sulfate levels in mucopolysaccharidoses and mucolipidoses. J Inherit Metab Dis 27:1-16.

Arruda, V.R., Stedman, H.H., Nichols, T.C., Haskins, M.E., Nicholson, M., Herzog, R.W., Couto, L.B., High, K.A. (2005) Regional intravascular delivery of AAV-2-F.IX to skeletal muscle of an isolated limb achieves long-term correction of hemophilia B in a large animal model. Blood 105:3458-3464.

Vite, C.H., Niogi, S.N., McGowan, J.C., Passini, M.A., Drobatz, K.J., Haskins, M.E. and Wolfe, J.H. (2005) Effective gene therapy for an inherited diffuse CNS disease in a large animal model. Ann. Neurol 57:355-364.

Simonaro, C.M., D'Angelo, M., Haskins, M.E, Schuchman, E.H. (2005) Joint and bone disease in mucopolysaccharidoses VI and VII: Identification of new therapeutic targets and biomarkers using animal models, Pediatr Res 57:701-707.

Volk, S.M., Diefenderfer, D.L., Christopher, S.A., Haskins, M.E., Leboy, P.S. (2005) Inducers of osteogenesis in canine mesenchymal stem cells. Am J Vet Res, in press.

Gomez, G, Lischka, F.W., Haskins, M.E. and Rawson, N.E. (2005) Evidence for multiple calcium response mechanisms in mammalian olfactory receptor neurons. Chemical Senses in press.

Walkley, S.U., Thrall, M.A., Haskins, M.E., Mitchell, T.W., Wenger, D.A., Brown, D.E., Dial, S. and Seim, H. (2005) Abnormal neuronal metabolism and storage in mucopolysaccharidosis type VI (Maroteaux-Lamy) disease. Neuropathology and Applied Neurobiology in press.

Suter, S.E., Gouthro, T.A., McSweeney, P.A., Nash, R.A., Haskins, M.E., Felsburg, P.J.. Henthorn, P.S. (2005) Optimized transduction of canine pediatric CD34+ cells using an MSCV-based bicistronic vector Vet Research Communications (in press).