University of Pennsylvania: School of Veterinary Medicine

Richard R Miselis V.M.D., Ph.D.

Professor of Animal Biology
Head, Laboratories of Anatomy

Department of Animal Biology
3800 Spruce Street
School of Veterinary Medicine
University of Pennsylvania
Philadelphia , PA 19104-6010

Qualifications

1967 B.S., Tufts University, Biology

1973 V.M.D. University of Pennsylvania, Veterinary Medicine

1973 Ph.D., University of Pennsylvania, Biology

Research Interests

Neuroanatomy (circumventricular organs, hypothalamus, central autonomic nervous system, vagal complex, medulla, viscerotopography, viscerotopy); CNS; Visceral neuraxis; Vagus Nerve; Cranial nerves; Tract tracing techniques; Histochemistry; Immunocytochemistry; Neurotropic Virus; Pseudorabies virus - central nervous system transport; Drinking behavior; Feeding behavior; Salt appetite; Body weight control.

Related areas of expertise: Physiology of water balance, food intake and body weight control Physiology of Sodium balance

Selected Publications

Daniels, D., Miselis, R.R., and Flanagan-Cato, L.M. Central Neuronal Circuit Innervating the Lordosis-Producing Muscles Defined by Transneuronal Transport of Pseudorabies Virus. J. Neurosci., 19: 2823-2833, 1999.
Yang, M., Card, J.P., Tirabassi, R.S., Miselis, R.R. and L.W. Enquist. Retrograde, transneuronal spread of pseudorabies virus in defined neuronal circuitry of the rat brain is promoted by gE mutations that reduce virulence. J. Virol. 1999. 73:4350-4359, 1999.
Yang, M., Zhao, X. and Miselis, R.R.: The origin of catecholamine fibers in the subdiaphragmatic vagus nerve of the rat. J. Autonomic Nerv. Sys., 76:108-117, 1999.
Valentino, R.J., Miselis, R.R. and Pavocovitch, L.A. Pontine regulation of pelvic viscera: pharmacological target for pelvic visceral dysfunctions. Trends Pharmacol. Sci., 20: 253-260, 1999.
Chen, S., Yang, M., Miselis, R.R., and Aston-Jones, G. Characterization of transsynaptic tracing with central application of pseudorabies virus. Brain Res., 838: 171-183, 1999.
Valentino, R.J., Kosboth, M ., Colflesh, M., Miselis, R.R. Transneuronal labeling from the rat distal colon: Anatomic evidence for regulation of distal colon function by a pontine corticotropin-releasing factor system. J. Comp. Neurol., 417: 399-414, 2000.
Shammah-Lagnado, S.J., Beltramino, C.A., McDonald, A.J., Miselis, R.R., Yang, M., de Olmos, J., Heimer, L., and Alheid, G.F. The supracapsular bed nucleus of the stria terminalis contains central and medial extended amygdala elements: Evidence from anterograde and retrograde tracing experiments in the rat. J Comp Neurol. 2000 Jul 10;422(4):533-55.
Daniels, D., Miselis, R.R., and Flanagan-Cato, L.M. Transneuronal tracing from sympathectomized lumbar epaxial muscle in female rats. J. Neurobiology, 48(4):278-90, 2001.
Velde K, Ross MW, Orsini JA, Parente EJ, Foley B, Richardson DW, Miselis RR. Tracing axons of peripheral nerves in rats: a potential technique to study the equine recurrent laryngeal nerve. J Invest Surg. 2004 May-Jun;17(3):151-62.
McKinley MJ, Mathai ML, McAllen RM, McClear RC, Miselis RR, Pennington GL, Vivas L, Wade JD, Oldfield BJ. Vasopressin secretion: osmotic and hormonal regulation by the lamina terminalis. J Neuroendocrinol. 2004 Apr;16(4):340-7.
Rouzade-Dominguez ML, Miselis R, Valentino RJ. Central representation of bladder and colon revealed by dual transsynaptic tracing in the rat: substrates for pelvic visceral coordination. Eur J Neurosci. 2003 Dec;18(12):3311-24.
Daniels D, Miselis RR, Flanagan-Cato LM. Hypothalamic co-localization of substance P receptor and transneuronal tracer from the lordosis-relevant lumbar epaxial muscles in the female rat. Neurosci Lett. 2003 Feb 27;338(2):111-4.
Holt, D.E., Cole, S.G., Anderson, R.B., Miscelis, R.R. and Bridges, C.R. The canine caudal accessory lobe pulmonary veins: Revised anatomical description, clinical relevance, and embryological implications. Anat. Histol. Embryol., 34: 1-3. 2005.