University of Pennsylvania: School of Veterinary Medicine

Bernard H Shapiro Ph.D.

Professor of Biochemistry

Department of Animal Biology

Qualifications

1960-64 A.B. Hunter College of the City University of New York, NY

1964-65 VM.S. University of New Hampshire, Durham, NH

1965-70 Ph.D. Rutgers University, New Brunswick, NJ

Research Interests

Growth hormone regulation of hepatic gender-dependent iso forms of CYP. Identify growth hormone-dependent signal transduction pathways, as well as imprinting mechanisms, inducing and suppressing individual forms of CYP, characteristic of male and female liver.

Selected Publications

Sharma, M.C., Agrawal, A.K., Sharma, M.R.. and Shapiro, B.H.: Interactions of gender, growth hormone and phenobarbital induction on murine Cyp2b expression. Biochem. Pharmacol., 56:1251-1258, 1998.
Pampori, N.A. and Shapiro, B.H.: Gender differences in the responsiveness of the sex-dependent isoforms of hepatic P450 to the feminine plasma growth hormone profile. Endocrinology, 140:1245-1254, 1999.
Agrawal, A.K. and Shapiro, B.H.: Differential expression of gender-dependent hepatic isoforms of cytochrome P450 by the pulse signals in the circulating masculine episodic growth hormone profile of the rat. J.Pharmacol.Exp.Ther., 292:228-237, 2000.
Agrawal, A.K. and Shapiro, B.H.: Latent overexpression of hepatic CYP2C7 in adult male and female rats neonatally exposed to phenobarbital: A developmental profile of gender-dependent P450s. J.Pharmacol.Exp.Ther. 293:1027-1033, 2000.
Pampori, N.A. and Shapiro, B.H.: Nominal growth hormone pulses in otherwise normal masculine plasma profiles induce intron retention of over-expressed hepatic CYP2C11 with associated nuclear splicing deficiency. Endocrinology 141: 4100-4106, 2000.
Agrawal, A.K. and Shapiro, B.H. Intrinsic signals in the sexually dimorphic circulation growth hormone profiles of the rat. Mol Cell Endocrinol., 173: 167-181, 2001.
Pampori, N.A., Agrawal, A.K., and Shapiro, B.H.: Infusion of gender-dependent plasma growth hormone profiles into intact rats: effects of subcutaneous, intraperitoneal, and intravenous routes of rat and human growth hormone on endogenous circulating growth hormone profiles and expression of sexually dimorphic hepatic CYP isoforms. Drug Metab Dispos. 29:8-16, 2001.
Garcia, M.C., Thangavel C., Shapiro, B.H. Epidermal growth factor regulation of female-dependent CYP2A1 and CYP2C12 in primary rat hepatocyte culture. Drug Metab Dispos. 29: 111-120, 2001.