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  Faculty
Sydney M. Evans V.M.D., M.S., Dip. A.C.V.R.
Associate Professor of Radiology Oncology, School of Medicine

Department of Clinical Studies -Philadelphia
3900 Delancey Street
School of Veterinary Medicine
University of Pennsylvania
Philadelphia, PA   19104-6010
Qualifications

1970-1973 BS, Rutgers University, College of Agriculture and Environmental Science, New Brunswick, N.J.
1973-1977 VMD, Cum Laude; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pa.
1982-1985 MS, University of Pennsylvania, Biomedical Studies, Comparative Medical Sciences. Thesis: Response of Human Neuroblastoma and Melanoma Multicellular Spheroids to Single Dose Irradiation.

Postgraduate Training:
1977-1978 Intern, Veterinary Hospital of the University of Pennsylvania, Philadelphia, Pa.
1979-1982 Resident, Section of Radiology, Veterinary Hospital of the University of Pennsylvania, Philadelphia, Pa.

Specialty Certification:
1985 American College of Veterinary Radiology

Clinical Interests
Diagnostic Radiology Radiation Therapy
Research Interests
Tumor Physiology Radiation Resistance
Selected Publications

1. Evans SM, Biery D:  Peritoneopericardial diaphragmatic hernia in the dog and cat: a literature review and 17 additional case histories. Veterinary Radiology, 21:108-116, 1980.

2. Evans SM, Laufer I:  Double contrast gastrography in the normal dog. Veterinary Radiology, 22:1-22, 1981.

3. Evans SM:  Double contrast gastrography in the cat. Veterinary Radiology, 24:3-4, 1983.

4. Evans SM:  Double versus single contrast gastrography in the dog and cat. Veterinary Radiology, 24:6-10, 1983.

5. Evans SM, Thrall DE:  Postoperative orthovoltage radiation therapy of parotid salivary gland adenocarcinoma. Journal of the American Veterinary Medical Association, 182:933-934, 1983.

6. Evans SM, Labs L, Yuhas JM:  Response of human neuroblastoma and melanoma multicellular tumor spheroids (MTS) to single dose irradiation. International Journal Radiation Oncology, Biology , Physics, 12:969-973, 1986.

7. Evans SM:  Canine hemangiopericytoma: a response to surgery and orthovoltage radiation. Veterinary Radiology, 28:13-16, 1987.

8. Evans SM, Shofer F:  Prognostic factors and survival in irradiated canine oral non-tonsillar squamous cell carcinoma. Veterinary Radiology, 29:133-137, 1988.

9. Evans SM, Goldschmidt MH, McKee L, Harvey CE:  Prognostic factors and survival following radiation therapy for canine intranasal neoplasms: 70 cases (1974-1985).  Journal of the American Veterinary Medical Association, 194:1460-1463, 1989.

10. Evans SM, Hendrick M:  Survival in cats treated with radiation therapy for intranasal tumors. Veterinary Radiology, 30:128-132, 1989.

11. Evans SM, LaCreta F, Helfand S, Van Winkle T, Curran  WJ Jr., Brown DQ, Hanks G:  Technique, pharmacokinetics, toxicity and efficacy of intratumoral etanidazole and radiotherapy for treatment of spontaneous feline oral squamous cell carcinoma. International Journal of Radiation Oncology, Biology ,Physics, 20: 703-708, 1991.

12. Evans SM, Van Winkle T, Michel K, Kennedy AR:  Protection against radiation induced thymic lymphosarcoma in c57bl/6 mice by an autoclave resistant factor present in soybeans. Radiation Research, 132:259-262, 1992.

13. Evans SM, Dayrell-Hart B, Powlis W, Christie G, Van Winkle T:  Orthovoltage radiation therapy of canine brain masses. Journal of Veterinary Internal Medicine, 7:216-219,1993.

14. Evans SM, Koch CJ, Joiner B, Jenkins WT, Laughlin KM, Lord EM:  2-nitroimidazole binding for identification of hypoxic cell fraction in cells and tissues of epigastric 9L tumors. British Journal of Cancer, 72:875-882, 1995.

15. Koch CJ, Evans SM, Lord EM:  Oxygen dependence of cellular uptake of EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide): analysis of drug adducts by fluorescent antibodies vs. bound radioactivity. British Journal of Cancer, 72:865-870, 1995.

16. Thrall DE, Prescott DM, Samulski TV, Denman DL, Legorreta RL, Rosner GL, Dodge RK, Page RL, Cline JM, Lee J, Evans SM, Oleson JR, Dewhirst MW:  Radiation and local hyperthermia vs. radiation and whole body hyperthermia combined with local hyperthermia in canine sarcomas. International Journal Radiation Oncology, Biology, Physics. 34:1087-1096, 1995.

17. Evans SM, Jenkins WT, Joiner B, Lord EM, Koch CJ:  2-nitroimidazole binding predicts radiation resistance in individual 9L subcutaneous tumors. Cancer Research, 56:405-411, 1996.

18. Evans SM, Jenkins WT, Shapiro M, Laughlin K, Chan C, Koch CJ:  Evaluation of the concept of "hypoxic fraction" as a descriptor of tumor oxygenation status. Advances in Experimental Biology and Medicine, 411:215-225, 1997.

19. Evans SM, Lord EM, Bergeron M, Bialik S, Ferriero D, Hermeking H, Kitsis RN, Schwentker A, Vogelstein B, Koch CJ:  Imaging hypoxia in diseased tissues. Advances in Experimental Biology and Medicine  428, 585-594, 1998.

20. Evans SM, Laughlin KM, Pugh CR, Sehgal CM, Saunders HM:  Use of power Doppler ultrasound guided biopsies to locate regions of tumor hypoxia. British Journal of Cancer, 76: 1308-1314, 1997. 

21. Evans SM, Koch CJ, Laughlin KM, Jenkins WT, Van Winkle T, Wilson DF:  Tamoxifen induces hypoxia in MCF-7 xenografts. Cancer Research, 57, 5155- 5162, 1997.

22.  Evans SM,  Kachur AV,  Shiue C.-Y, Hustinx R, Jenkins WT,  Shiue GG,  Karp JS, Alavi A, Lord EM, Dolbier WR Jr., Koch CJ. Non-invasive detection of tumor hypoxia using the 2-nitroimidazole [18F]-EF1. Journal of Nuclear Medicine, 41:327-336, 2000

23. Evans SM, Hahn S,  Pook DR, Jenkins WT,  Chalian AA, Zhang P, Stevens C, Weber R, Weinstein G, Benjamin I, Mirza N,  Morgan M, Rubin S,  McKenna WG, Lord EM, Koch CJ.   Detection of hypoxia in human squamous cell carcinoma by EF5 binding. Cancer Research, 60: 2018-2024, 2000