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CHARLES H. VITE, DVM, PhD, B.S.
Associate Professor Veterinary Neurology, Section of Neurology & Neurosurgery, Department of Clinical Studies, School of Veterinary Medicine University of Pennsylvania

Diplomate, ACVIM (Neurology)

Research Areas: Epilepsy, Feline and Canine models of neurodegenerative diseases, Feline Niemann-Pick Type C Disease, Niemann-Pick type C disease, Neurodegenerative diseases, Neurology,

Contact Information:
Section of Neurology & Neurosurgery
Department of Clinical Studies - Philadelphia
School of Veterinary Medicine
University of Pennsylvania
3900 Delancey Street
 Phone 215-898-9473
 Fax 215-898-9937
 Email vite@vet.upenn.edu

My interests focus on diseases of the brain including epilepsy, neurodegenerative processes, and neurodevelopmental processes. My clinical expertise focuses on improving the diagnosis of disease using nuclear magnetic resonance methods and clinical trials to assess the efficacy of new therapies for currently untreatable disease. I also have specific interests in epilepsy, vestibular dysfunction and myotonia congenita.

The focus of my lab is to improve the characterization and treatment of neurological diseases by studying naturally-occurring feline and canine models of human diseases. Our lab develops and identifies ante mortem biochemical and nuclear magnetic resonance markers of disease severity and progression and uses these markers to evaluate the efficacy of gene therapy, cell-based therapy, and pharmacotherapy to treat disease.
We currently maintain breeding colonies that produce cats affected with Niemann-Pick type C disease and alpha-mannosidosis, and dogs affected with globoid cell leukodystrophy and mucopolysaccharidoses. We also maintain dogs with naturally occurring epilepsy for which we are evaluating neurophysiologically-based response pharmacotherapy using intracranially EEG. The goal of this work is to develop methods to predict seizure occurrence and to prevent them. We will implant devices and maintain epileptic dogs proposed for use in this study.

Howbert, J Jeffry. Patterson, Edward E. Stead, S Matt. Brinkmann, Ben. Vasoli, Vincent. Crepeau, Daniel. Vite, Charles H. Sturges, Beverly. Ruedebusch, Vanessa. Mavoori, Jaideep. Leyde, Kent. Sheffield, W Douglas. Litt, Brian. Worrell, Gregory A. Forecasting seizures in dogs with naturally occurring epilepsy. PLoS ONE [Electronic Resource] 9: e81920, 2014.

Swain, G P. Prociuk, M. Bagel, J H. O'Donnell, P. Berger, K. Drobatz, K. Gurda, B L. Haskins, M E. Sands, M S. Vite, C H. Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain. Gene Therapy 21: 28-36, 2014.

Coles, Lisa D. Patterson, Edward E. Sheffield, W Douglas. Mavoori, Jaideep. Higgins, Jason. Michael, Bland. Leyde, Kent. Cloyd, James C. Litt, Brian. Vite, Charles. Worrell, Gregory A. Feasibility study of a caregiver seizure alert system in canine epilepsy. Epilepsy Research 106: 456-60, 2013.

Fan, Martin. Sidhu, Rohini. Fujiwara, Hideji. Tortelli, Brett. Zhang, Jessie. Davidson, Cristin. Walkley, Steven U. Bagel, Jessica H. Vite, Charles. Yanjanin, Nicole M. Porter, Forbes D. Schaffer, Jean E. Ory, Daniel S. Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling. Journal of Lipid Research 54: 2800-14, 2013.

Roszell, Blair R. Tao, Jian-Qin. Yu, Kevin J. Gao, Ling. Huang, Shaohui. Ning, Yue. Feinstein, Sheldon I. Vite, Charles H. Bates, Sandra R. Pulmonary abnormalities in animal models due to Niemann-Pick type C1 (NPC1) or C2 (NPC2) disease. PLoS ONE [Electronic Resource] 8: e67084, 2013.

Bagel, Jessica H. Sikora, Tracey U. Prociuk, Maria. Pesayco, Jill P. Mizisin, Andrew P. Shelton, G Diane. Vite, Charles H. Electrodiagnostic testing and histopathologic changes confirm peripheral nervous system myelin abnormalities in the feline model of niemann-pick disease type C. Journal of Neuropathology & Experimental Neurology 72: 256-62, 2013.

Malik, Saafan Z. Lewis, Melissa. Isaacs, Alison. Haskins, Mark. Van Winkle, Thomas. Vite, Charles H. Watson, Deborah J. Identification of the rostral migratory stream in the canine and feline brain. PLoS ONE [Electronic Resource] 7: e36016, 2012.

Stein, Veronika M. Crooks, Alexandra. Ding, Wenge. Prociuk, Maria. O'Donnell, Patricia. Bryan, Caroline. Sikora, Tracey. Dingemanse, Jasper. Vanier, Marie T. Walkley, Steven U. Vite, Charles H. Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C. Journal of Neuropathology & Experimental Neurology 71: 434-48, 2012.

Porter, Forbes D. Scherrer, David E. Lanier, Michael H. Langmade, S Joshua. Molugu, Vasumathi. Gale, Sarah E. Olzeski, Dana. Sidhu, Rohini. Dietzen, Dennis J. Fu, Rao. Wassif, Christopher A. Yanjanin, Nicole M. Marso, Steven P. House, John. Vite, Charles. Schaffer, Jean E. Ory, Daniel S. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Science Translational Medicine 2: 56ra81, 2010.

Ward, Sarah. O'Donnell, Patricia. Fernandez, Steven. Vite, Charles H. 2-hydroxypropyl-beta-cyclodextrin raises hearing threshold in normal cats and in cats with Niemann-Pick type C disease. Pediatric Research 68: 52-6, 2010.

DVM Purdue University, 1990

PhD University of Pennsylvania, 2003

B.S. Cornell University, 1986