Dr Brown's clinical interest is in the management of chronic pain in pets, particularly those with joint pain, cancer pain, and oral pain. She is specifically interested in identifying new strategies to manage chronic pain in those animals that are failing conventional pain management.
Dr Brown’s research focuses on development and validation of outcome assessment instruments for chronic pain in companion animals and then the application of those instruments to companion animal clinical trials evaluating the efficacy of novel interventions for chronic pain in those species. This work is funded by industry and foundation sponsors that have a direct interest in companion animal pain management, as well as NIH and industry sponsors that are focused on human health, yet realize the extent to which companion animals, such as dogs with pain due to bone cancer, osteoarthritis, or oral mucositis make excellent preclinical models of these human chronic pain states. Dr Brown directs the Veterinary Clinical Investigations Center (VCIC) utilizing her degree in Master of Science in Clinical Epidemiology, Clinical Trials Track, from the University Of Pennsylvania School Of Medicine. Through the VCIC, Dr Brown matches investigators from the faculty and staff at the School of Veterinary Medicine with the expertise needed for a given sponsored study and then advises on the study design, data collection, management and analysis for successful completion of that study. The VCIC works to expand interdisciplinary collaborations between human and animal health, expeditiously expanding the knowledge base for both human and non-human species, accelerating biomedical research discoveries.
Brown Dorothy Cimino, Reetz Jennifer Single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcoma. Evidence-based complementary and alternative medicine : eCAM 2012: 384301, 2012.Michel, Kathryn E. Brown, Dorothy Cimino. Determination and application of cut points for accelerometer-based activity counts of activities with differing intensity in pet dogs. American Journal of Veterinary Research 72: 866-70, 2011.Brown, Dorothy Cimino. Boston, Raymond C. Farrar, John T. Use of an activity monitor to detect response to treatment in dogs with osteoarthritis. Journal of the American Veterinary Medical Association 237: 66-70, 2010.Dow, Caitlin. Michel, Kathryn E. Love, Molly. Brown, Dorothy Cimino. Evaluation of optimal sampling interval for activity monitoring in companion dogs. American Journal of Veterinary Research 70: 444-8, 2009.Brown, Dorothy Cimino. Boston, Raymond. Coyne, James C. Farrar, John T. A novel approach to the use of animals in studies of pain: validation of the canine brief pain inventory in canine bone cancer. Pain Medicine 10: 133-42, 2009.Brown, Dorothy Cimino. Boston, Raymond C. Coyne, James C. Farrar, John T. Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis. Journal of the American Veterinary Medical Association 233: 1278-83, 2008.Brown, Dorothy Cimino. Boston, Raymond C. Coyne, James C. Farrar, John T. Development and psychometric testing of an instrument designed to measure chronic pain in dogs with osteoarthritis. American Journal of Veterinary Research 68: 631-7, 2007.Brown, Dorothy Cimino. Control of selection bias in parallel-group controlled clinical trials in dogs and cats: 97 trials (2000-2005). Journal of the American Veterinary Medical Association 229: 990-3, 2006.Brown, Dorothy Cimino. Iadarola, Michael J. Perkowski, Sandra Z. Erin, Hardam. Shofer, Frances. Laszlo, Karai J. Olah, Zoltan. Mannes, Andrew J. Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model. Anesthesiology 103: 1052-9, 2005.Karai, Laszlo. Brown, Dorothy C. Mannes, Andrew J. Connelly, Stephen T. Brown, Jacob. Gandal, Michael. Wellisch, Ofer M. Neubert, John K. Olah, Zoltan. Iadarola, Michael J. Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control. Journal of Clinical Investigation 113: 1344-52, 2004.
BS (Zoology ) The University of Maryland at College Park, College Park, Maryland, 1988DVM (Doctor of Veterinary Medicine ) Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia, 1992MSCE (Master of Science in Clinical Epidemiology) University of Pennsylvania, School of Medicine, Philadelphia, PA, 2006