My primary expertise and research interest is veterinary orthopedic pathology, which includes basic and applied (clinical and translational) research projects with collaborators within the PennVet, PennMed, extramural academic institutions, and industry.
One focus pertains to equine laminitis. Collaborations include PennVet's Laminitis Research Laboratory (Dr. Galantino-Homer and Dr. Kurt Hankenson) and Laminitis Institute (Dr. James Orsini) at the School of Veterinary Medicine, New Bolton Center. The goal of the research is to correlate pathological with molecular (genomic & proteomic) data to more completely understand the pathogenesis of laminintis and to identify potential biomarkers of disease.
A secondary focus involves collaboration with Dr. Thomas Schaer at the New Bolton Center's Comparative Orthopedic Research Laboratory (CORL), which utilizes various animal models to evaluate experimental orthopedic surgical implant devices and biomaterials.
A tertiary research interest pertains to gastrointestinal pathology in horses (post ischemic injury, inflammation and post-surgical enteric wound healing, spontaneous equine colic and colitis, and equine enteric microbiome). This research includes collaboration with Dr. Louise Southwood and Dipti Pitta, Dept. of Clinical Studies- New Bolton Center, Dipti Pitta, UPenn's Center for Host-Microbiome Interactions (CHMI), as well as other clinicians at New Bolton Center.
Primary academic research affiliations
Drs. Hannah Galantino-Homer (Laminitis research), Kurt Hankenson (basic and applied musculoskeletal research), Dr. Dean Richardson (basic and applied musculoskeletal research), Dr. Tomas Schaer- CORL (Comparative Orthopedic Research Laboratory), Dr. Louise Southwood (clinical and translational orthopedic and gastrointestinal research), Dipti Pitta (equine microbiomic research), Dr. Chris Hunter (basic orthopedic and immunology research), Dr. Nicola Mason (canine osteosarcoma research).
Stewart Suzanne, Barr Stephanie, Engiles Julie, Hickok Noreen J, Shapiro Irving M, Richardson Dean W, Parvizi Javad, Schaer Thomas P Vancomycin-modified implant surface inhibits biofilm formation and supports bone-healing in an infected osteotomy model in sheep: a proof-of-concept study. The Journal of bone and joint surgery. American volume 94: 1406-15, 2012.Morello Samantha, Southwood Louise L, Engiles Julie, Slack Joann, Crack Aaron, Springate Christopher M K Effect of intraperitoneal PERIDAN™ concentrate adhesion reduction device on clinical findings, infection, and tissue healing in an adult horse jejunojejunostomy model. Veterinary surgery : VS 41: 568-81, 2012.Stock ML, Smith BI, Engiles JB Disseminated hemangiosarcoma in a cow Canadian Veterinary Journal 52: 409-413, 2011.R.A. Carter, J.B. Engiles, S.O. Megee, M. Senoo, H.L. Galantino-Homer. Decreased expression of p63, a regulator of epidermal stem cells, in the chronic laminitic equine hoof. Equine Veterinary Journal. : Epub., 2011.GA Tyner, RD Nolen-Walston, T Hall, JP Palmero, L Coutëil, L Javsicas, A Stack, H Schott, A Johnson, L Hardefeldt, A Gruntman, C Sommardahl, N Menzies-Gow, P dePedro, T Norman, LC Fennell, JE Axon, S Lindborg, H Aceto, R Boston, J Engiles. A multicenter retrospective study of 151 renal biopsies in horses Journal of Veterinary Internal Medicine : Epub., 2011.James, Frances M. Engiles, Julie B. Beech, Jill. Meningitis, cranial neuritis, and radiculoneuritis associated with Borrelia burgdorferi infection in a horse. Journal of the American Veterinary Medical Association 237: 1180-5, 2010.Engiles, Julie B. Pathology of the distal phalanx in equine laminitis: more than just skin deep. [Review] [43 refs] Veterinary Clinics of North America - Equine Practice 26: 155-65, 2010.Ahern, B. J. Engiles, J. Smith, J. J. Parente, E. J. Paranasal sinus fibromatosis in a horse. Equine Veterinary Education. 22: 23-28, 2010.Nolen-Walston, R D. Parente, E J. Madigan, J E. David, F. Knafo, S E. Engiles, J B. Branchial remnant cysts of mature and juvenile horses. Equine Veterinary Journal 41: 918-23, 2009.H.L. Reesink*, E.J. Parente, P.L. Sertich, J.B. Engiles*. Malignant fibrous histiocytoma of the mammary gland in a mare. Equine Veterinary Education. : , 2009..M. A. Smith*, D. G. Levine, L. M. Getman, E. J. Parente, J. B. Engiles.* Vulvar squamous cell carcinoma in situ within viral papillomas in an aged Quarter Horse mare. Equine Veterinary Education. 21:1: 11-16, 2009.
B.A. (Biophysics, Dean's Scholar Program) University of Delaware, 1994VMD School of Veterinary Medicine, University of Pennsylvania, 2002Internship New Jersey Equine Clinic, Millstone, NJ, 2003Dip. ACVP (Residency in Veterinary Pathology ) University of Pennsylvania, 2006