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LAWRENCE R. SOMA, VMD,

Founding Member, American College of Veterinary Anesthesiology

Research Areas: Race horse screening for Anabolic and Androgenic Steroids, Pharmacokinetics, Pharmacology

Contact Information:
University of Pennsylvania
School of Veterinary Medicine
Dept of Clinical Studies
New Bolton Center
382 West Street Road
 Phone 610-925-6265
 Fax 610-925-6820
 Email soma@vet.upenn.edu

Soma LR, Guan F, Uboh CE, Luo Y, Driessen B Pharmacokinetics of hemoglobin-based oxygen carrier-200 (HBOC-200; Oxyglobin®) in the Horse. Anesthesia & Analgesia 100: 1570-1575, 2005.

Luo Y, Uboh CE, Soma LR, Guan F, Rudy JA, Tsang DS Simultaneous analysis of twenty-one glucocorticoids in equine plasma by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 19: 1245-1256, 2005.

Guan F, Uboh CE, Soma LR, Luo Y, Rudy J, Tobin T Detection, quantification and confirmation of anabolic steroids in equine plasma by liquid chromatography and tandem mass spectrometry. Journal of Chromatography B 829: 56-59, 2005.

Soma LR, Uboh CE, Luo Y, Guan F, Moat PJ, Boston RC Pharmacokinetics of Intra-articular Administration of Methylprednisolone Acetate: Effect on Endogenous Hydrocortisone and Cortisone in the Horse. American Journal of Veterinary Research 67: 654-662 , 2006.

Guan F, CE Uboh, LR Soma, Y Luo, and S Petterman Collision-induced decomposition of anabolic steroids by electrospray ionization quadrupole time-of-flight (QTOF). Mass Spectrometry 17: 477-489, 2006.

Lankveld DPK, Driessen B, Soma LR, Moate PJ, Rudy J, Uboh CE, van Dijk P & Hellebrekers LJ Pharmacodynamic effects and pharmacokinetic profile of a long-term continuous rate infusion of racemic ketamine in healthy conscious horses. Journal of Veterinary Pharmacology & Therapeutics 29 : 477-488 , 2006.

Orsini JA, Moate PJ, Kuersten K, Soma LR, Boston RC Pharmacokinetics of fentanyl delivered transdermally in healthy adult horses-variability among horses and clinical implications. Journal of Veterinary Pharmacology & Therapeutics 29: 539-546, 2006.

Soma LR, Uboh CE, Guan F, McDonnell S, Pack J Pharmacokinetics of Boldenone and Stanozolol and the Results of Screening for Anabolic and Androgenic Steroids and in Race Horses and Non-Race Horses. Journal of Veterinary Pharmacology & Therapeutics 30: 101-108, 2006.

Guan F, Uboh CE, Soma LR, Birks E, Chen J, You Y, Xu F, Mbuy G Extraction and Confirmation of Recombinant Human Epo and Darbepoetin-Alpha in Equine Plasma by LC-MS. Anal Chem 79: 4627-4635 , 2007.

You Y, Uboh CE, Soma LR, Guan F, Rudy J Determination of Alcohol Administration Biomarkers: Ethyl Glucuronide and Ethyl Sulfate in Equine Urine by Liquid Chromatography-Tandem Mass Spectrometry. Rapid Communications Mass Spectrometry 21: 3785-3794, 2007.

Read Jennifer R, Boston Raymond C, Abraham Getu, Bauquier Sebastien H, Soma Lawrence R, Nolen-Walston Rose D Effect of prolonged administration of clenbuterol on airway reactivity and sweating in horses with inflammatory airway disease. American journal of veterinary research 73: 140-5, 2012.

Guan Fuyu, Uboh Cornelius E, Soma Lawrence R, You Youwen, Li Xiaoqing, McDonnell Sue Ex vivo spontaneous generation of 19-norandrostenedione and nandrolone detected in equine plasma and urine. The Journal of steroid biochemistry and molecular biology 128: 1-11, 2012.

Soma Lawrence R, Uboh Cornelius E, You Yowen, Guan Fuyu, Boston Raymond C Pharmacokinetics of intra-articular, intravenous, and intramuscular administration of triamcinolone acetonide and its effect on endogenous plasma hydrocortisone and cortisone concentrations in horses. American journal of veterinary research 72: 1234-42, 2011.

Liu Ying, Uboh Cornelius E, Soma Lawrence R, Li Xiaoqing, Guan Fuyu, You Youwen, Chen Jin-Wen Efficient use of retention time for the analysis of 302 drugs in equine plasma by liquid chromatography-MS/MS with scheduled multiple reaction monitoring and instant library searching for doping control. Analytical chemistry 83: 6834-41, 2011.

You Youwen, Uboh Cornelius E, Soma Lawrence R, Guan Fuyu, Li Xiaoqing, Liu Ying, Rudy Jeffrey A, Chen Jinwen, Tsang Deborah Simultaneous separation and determination of 16 testosterone and nandrolone esters in equine plasma using ultra high performance liquid chromatography-tandem mass spectrometry for doping control. Journal of chromatography. A 1218: 3982-93, 2011.

Guan Fuyu, Uboh Cornelius E, Soma Lawrence R, Rudy Jeffrey Sequence elucidation of an unknown cyclic peptide of high doping potential by ETD and CID tandem mass spectrometry. Journal of the American Society for Mass Spectrometry 22: 718-30, 2011.

Liu Ying, Uboh Cornelius E, Soma Lawrence R, Li Xiaoqing, Guan Fuyu, You Youwen, Rudy Jeffrey A, Chen Jin-Wen Analysis of gabapentin in equine plasma with measurement uncertainty estimation by liquid chromatography-tandem mass spectrometry. Journal of analytical toxicology 35: 75-84, 2011.

Mangal Dipti, Uboh Cornelius E, Soma Lawrence R Analysis of bioactive eicosanoids in equine plasma by stable isotope dilution reversed-phase liquid chromatography/multiple reaction monitoring mass spectrometry. Rapid communications in mass spectrometry : RCM 25: 585-98, 2011.

Guan Fuyu, Uboh Cornelius E, Soma Lawrence R, Maylin George, Jiang Zibin, Chen Jinwen Confirmatory Analysis of Continuous Erythropoietin Receptor Activator and Erythropoietin Analogues in Equine Plasma by LC-MS for Doping Control. Analytical chemistry : , 2010.

Liu Ying, Uboh Cornelius E, Soma Lawrence R, Li Xiaoqing, Guan Fuyu, You Youwen, Rudy Jeffrey A, Chen Jin-Wen Detection and confirmation of 60 anabolic and androgenic steroids in equine plasma by liquid chromatography-tandem mass spectrometry with instant library searching. Drug testing and analysis 3: 54-67, 2011.

Guan Fuyu, Uboh Cornelius E, Soma Lawrence R, You Youwen, Liu Ying, Li Xiaoqing High-throughput UHPLC-MS/MS method for the detection, quantification and identification of fifty-five anabolic and androgenic steroids in equine plasma. Journal of mass spectrometry : JMS 45: 1270-9, 2010.

Chen Jin-Wen, Uboh Cornelius E, Soma Lawrence R, Li Xiaoqing, Guan Fuyu, You Youwen, Liu Ying Determining the source of equine bloodstains by dinucleotide repeats. Journal of forensic sciences 55: 1610-4, 2010.

Chen Jin-Wen, Uboh Cornelius E, Soma Lawrence R, Li Xiaoqing, Guan Fuyu, You Youwen, Liu Ying Identification of racehorse and sample contamination by novel 24-plex STR system. Forensic science international. Genetics 4: 158-67, 2010.

VMD (Veterinary Medicine) University of Pennsylvania, 1957

(Pre-Vet) University of Connecticut, 1953