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New Bolton Center Kennett Square, PA
Emergencies & Appointments:
610-444-5800
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Ryan Hospital Philadelphia, PA
Emergencies:
215-746-8911
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215-746-8387
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MANTI GUHA, PhD

Research Assistant Professor, Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine

Research Areas: Mitochondrial defects in cellular reprogramming; Epithelial-mesenchymal transition and mammary tumor metastasis;  Chromatin modifications;  Transcriptional regulation of nuclear genes;  Regulation of telomere and telomerase

Contact Information:

Mitochondrial retrograde signaling; Mitochondrial DNA depletion and breast cancer metastasis

Tanaka, K., Whelan, K. A., Chandramouleeswaran, P. M., Kagawa, S., Rustgi, S. L., Noguchi, C., Guha, M., Srinivasan, S., Amanuma, Y., Ohashi, S., Muto, M., Klein-Szanto, A. J., Noguchi, E., Avadhani, N. G., Nakagawa, H. ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds Am J Cancer Res 6: 781-796, 2016.

Srinivasan, S., Guha, M., Dong, D. W., Whelan, K. A., Ruthel, G., Uchikado, Y., Natsugoe, S., Nakagawa, H., Avadhani, N. G. Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming Oncogene 35: 1585-1595, 2016.

Srinivasan, S., Guha, M., Avadhani, N. G. Mitochondrial respiratory defects promote the Warburg effect and cancer progression Mol Cell Oncol 3: e1085120, 2016.

Zhang, G., Frederick, D. T., Wu, L., Wei, Z., Krepler, C., Srinivasan, S., Chae, Y. C., Xu, X., Choi, H., Dimwamwa, E., Ope, O., Shannan, B., Basu, D., Zhang, D., Guha, M., Xiao, M., Randell, S., Sproesser, K., Xu, W., Liu, J., Karakousis, G. C., Schuchter, L. M., Gangadhar, T. C., Amaravadi, R. K., Gu, M., Xu, C., Ghosh, A., Xu, W., Tian, T., Zhang, J., Zha, S., Liu, Q., Brafford, P., Weeraratna, A., Davies, M. A., Wargo, J. A., Avadhani, N. G., Lu, Y., Mills, G. B., Altieri, D. C., Flaherty, K. T., Herlyn, M. Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors J Clin Invest 126: 1834-56, 2016.

Guha, M., Srinivasan, S., Koenigstein, A., Zaidi, M., Avadhani, N. G. Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene Ann N Y Acad Sci 1364: 52-61, 2016.

Whelan, K. A., Kinugasa, H., Tanaka, K., Srinivasan, S., Guha, M., St Clair, D., Klein-Szanto, A., Avadhani, N., Diehl, A., Rustgi, A., Nakagawa, H. Mitochondrial SOD2 regulates EMT and cancer stem cell-like cell populations Cancer Res 75: , 2015.

Kinugasa, H., Whelan, K. A., Tanaka, K., Natsuizaka, M., Long, A., Guo, A., Chang, S., Kagawa, S., Srinivasan, S., Guha, M., Yamamoto, K., St Clair, D. K., Avadhani, N. G., Diehl, J. A., Nakagawa, H. Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression Oncogene 34: 5229-5239, 2015.

Dong, D. W., Srinivasan, S., Guha, M., Avadhani, N. G. Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis Genom Data 6: 99-107, 2015.

Yu, Q., Katlinskaya, Y. V., Carbone, C. J., Zhao, B., Katlinski, K. V., Zheng, H., Guha, M., Li, N., Chen, Q., Yang, T., Lengner, C. J., Greenberg, R. A., Johnson, F. B., Fuchs, S. Y. DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function Cell Rep 11: 785-797, 2015.

Srinivasan, S., Guha, M., Dong, D., Ruthel, G., Whelan, K., Uchikado, Y., Natsugoe, S., Nakagawa, H., Avadhani, N. G. Cytochrome c Oxidase dysfunction induces retrograde signaling and invasive phenotype Mol Biol Cell 25: , 2014.

PhD (Life Sciences) Jadavpur University, 2003