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MARK A. OYAMA, DVM, MSCE
Professor, Department of Clinical Studies - Philadelphia, University of Pennsylvania School of Veterinary Medicine

Chief, Section of Cardiology, Veterinary Hospital of the University of Pennsylvania, School of Veterinary Medicine

Diplomate, American College of Veterinary Internal Medicine, Cardiology

Clinical Specialties: Cardiology, Cardiac Examinations, Echocardiograms, ECG, Non-invasive & Invasive Surgeries,
Research Areas: Animal models of heart disease Heart Disease Myxomatous mitral valve disease Cardiac biomarkers Clinical trials Epidemiology Biostatistics Diuretic resistance
PubMed Link
Contact Information:
Department of Clinical Studies-Philadelphia
Ryan Veterinary Hospital of the University of Pennsylvania
School of Veterinary Medicine
University of Pennsylvania
3900 Spruce St.




 Phone 215-898-3331
 Email

Canine and feline models of heart disease
Molecular mechanisms of myxomatous mitral valve disease
Diuretic resistance
Epidemiology and biostatistics

Cardiac biomarkers (troponin, natriuretic peptides [BNP, ANP])
Diuretic resistance
Clinical trials
Serotonin signaling and myxomatous valve disease
Animal models of heart disease and heart failure
Epidemiology and biostatistics

Cremer, Signe E; Kristensen, Annemarie T; Reimann, Maria J; Eriksen, Nynne B; Petersen, Stine F; Marschner, Clara B; Tarnow, Inge; Oyama, Mark A; Olsen, Lisbeth H. Plasma and serum serotonin concentrations and surface-bound platelet serotonin expression in Cavalier King Charles Spaniels with myxomatous mitral valve disease. American Journal of Veterinary Research 76: 520-31, 2015.

Fox, P R; Oyama, M A; Hezzell, M J; Rush, J E; Nguyenba, T P; DeFrancesco, T C; Lehmkuhl, L B; Kellihan, H B; Bulmer, B; Gordon, S G; Cunningham, S M; MacGregor, J; Stepien, R L; Lefbom, B; Adin, D; Lamb, K. Relationship of plasma N-terminal pro-brain natriuretic peptide concentrations to heart failure classification and cause of respiratory distress in dogs using a 2nd generation ELISA assay. Journal of Veterinary Internal Medicine 29: 171-9, 2015.

Machen, Maggie C; Oyama, Mark A; Gordon, Sonya G; Rush, John E; Achen, Sarah E; Stepien, Rebecca L; Fox, Philip R; Saunders, Ashley B; Cunningham, Suzanne M; Lee, Pamela M; Kellihan, Heidi B. Multi-centered investigation of a point-of-care NT-proBNP ELISA assay to detect moderate to severe occult (pre-clinical) feline heart disease in cats referred for cardiac evaluation. Journal of Veterinary Cardiology 16: 245-55, 2014.

Cremer, S E; Singletary, G E; Olsen, L H; Wallace, K; Haggstrom, J; Ljungvall, I; Hoglund, K; Reynolds, C A; Pizzinat, N; Oyama, M A. Serotonin concentrations in platelets, plasma, mitral valve leaflet, and left ventricular myocardial tissue in dogs with myxomatous mitral valve disease. Journal of Veterinary Internal Medicine 28: 1534-40, 2014.

Langhorn, R; Thawley, V; Oyama, M A; King, L G; Machen, M C; Trafny, D J; Willesen, J L; Tarnow, I; Kjelgaard-Hansen, M. Prediction of long-term outcome by measurement of serum concentration of cardiac troponins in critically ill dogs with systemic inflammation. Journal of Veterinary Internal Medicine 28: 1492-7, 2014.

Cremer, S E; Zois, N E; Moesgaard, S G; Ravn, N; Cirera, S; Honge, J L; Smerup, M H; Hasenkam, J M; Sloth, E; Leifsson, P S; Falk, T; Oyama, M A; Orton, C; Martinussen, T; Olsen, L H. Strong association between activated valvular interstitial cells and histopathological lesions in porcine model of induced mitral regurgitation. International Journal of Cardiology 174: 443-6, 2014.

Fonfara, Sonja; Hetzel, Udo; Oyama, Mark A; Kipar, Anja. The potential role of myocardial serotonin receptor 2B expression in canine dilated cardiomyopathy. Veterinary Journal 199: 406-12, 2014.

Oyama, Mark A. Using cardiac biomarkers in veterinary practice. [Review] Veterinary Clinics of North America - Small Animal Practice 43: 1261-72, vi, 2013.

Ljungvall, I; Hoglund, K; Lilliehook, I; Oyama, M A; Tidholm, A; Tvedten, H; Haggstrom, J. Serum serotonin concentration is associated with severity of myxomatous mitral valve disease in dogs. Journal of Veterinary Internal Medicine 27: 1105-12, 2013.

Langhorn, R; Oyama, M A; King, L G; Machen, M C; Trafny, D J; Thawley, V; Willesen, J L; Tarnow, I; Kjelgaard-Hansen, M. Prognostic importance of myocardial injury in critically ill dogs with systemic inflammation. Journal of Veterinary Internal Medicine 27: 895-903, 2013.

DVM (Doctor Veterinary Medicine) University of Illinois, 1994

MSCE (Masters of Science in Clinical Epidemiology) University of Pennslyvania, 2015