Our laboratory studies the signals that turn on and regulate the immune system during infections with common respiratory viruses, such as the influenza virus or the respiratory syncytial virus.
These viruses can cause or exacerbate chronic lung diseases, such as asthma, and can be fatal in some patients.
Our long-term goals are to better understand the factors that modulate virus pathogenesis and to harness this knowledge for the development of better vaccines and antiviral therapies.
Find us here in Penn Vet Research Labs and, if you want to find our most up-to-date research goals and news, click on the Lopez Laboratory link above or find us at www.lopezlab.org
Xu J, Mercado-López X, Grier J, Kim W, Chun L, Irvine EB, Del Toro Y, Kell A, Hur S, Gale M, Raj A, and López CB Identification of a Natural Viral RNA Motif that Facilitates Viral Recognition by RIG-I-Like Receptors mBio In press: , 2015.Sun Y, Jain D, Koziol-White CJ, Genoyer E, Gilbert M, Tapia K, Panettieri RA, Hodinka RL, and López CB Immunostimulatory Defective Viral Genomes Promote Strong Innate Antiviral Responses During Respiratory Syncytial Virus Infection in Mice and Humans PLOS Pathogens 11: e1005122. doi:10.1371/journal.ppat.1005122, 2015.Benitez AA, Panis M, Xue J, Shim JV, Varble A, Frick AL, López CB, Sachs D, and tenOever BR In vivo RNAi screening identifies MDA5 as a contributor to the cellular defense against influenza A virus Cell Reports 11: 1714-26, 2015.López CB Defective viral genomes: critical danger signals of viral infections (Gem-Review) J Virol 88: 8720-3, 2014.Kim WK, Jain D, Sánchez MD, Koziol-White CJ, Matthews K, Ge MQ, Haczku A, Panettieri RA Jr, Frieman MB, López CB. Deficiency of MDA5 Results in Exacerbated Chronic Post-Viral Lung Inflammation. Am J Respir Crit Care Med. 189: 437-48, 2014.Mercado-López X, Cotter CR, Kim WK, Muñoz L, Tapia K, and López CB. Highly Immunostimulatory RNA Derived from a Sendai Virus Defective Viral Genome. Vaccine 31(48): 5713-21, 2013.Tapia K, Kim WK, Sun Y, Mercado-López X, Dunay E, Wise M, Adu M, and López CB Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity. PLoS Pathogens 9(10): e1003703, 2013.Hermesh T, Moran TM, Jain. D, and López CB. Granulocyte colony-stimulating factor protects mice during respiratory virus infections. PLoS One 7(5):e37334: , 2012.López CB and Hermesh T Systemic Responses During Local Viral Infections: Type I IFNs Sound the Alarm Curr.Opi. Immunol. 23: 495-9, 2011.Hermesh Tamar, Moltedo Bruno, Moran Thomas M, López Carolina B Antiviral instruction of bone marrow leukocytes during respiratory viral infections. Cell host & microbe 7: 343-53, 2010.