News & Events in Biomedical Sciences

News in the Department

  •  03/20/2015: Dr. Chris Lengner, along with other Penn collaborators, has found evidence of a potential cause of colon cancer,  a protein called MSI2. Dr. Lengner is the senior author on a paper published in Nature Communications, which describes their findings. Read the article...

  • 03/04/2015:  Dr. Jeremy Wang, along with other Penn collaborators, published a paper describing the function of an enzyme critical to male fertility in Genes and Development. Read the article...

  • 08/27/2014: Dr. Peter Dodson and Brandon Hedrick featured on Philly.com for their work on a nest of fossilized juvenile dinosaurs.  Read the article...

  • 04/10/2014: Dr. Kendra Bence's work on obesity and related diseases featured in Penn Current.  Read the article...

  • 03/13/2014: Dr. Jeremy Wang's work with the Children's Hospital of Philadelphia featured in Penn Current.  Read the article...


Recent publications from the labs of Biomedical Sciences. 

  • Vourekas A, Zheng K, Fu Q, Maragkakis M, Alexiou P, Ma J, Pillai RS, Mourelatos Z, and Wang, PJ. MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes and Development. In press.
  • Suzuki D, Sahu R, Leu NA, Senoo M. The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. Development. Dec 11, 2014; pii: dev.118307 [Epub ahead of print]. PMID: 25503409.
  • Banerjee S, Das RK, and Shapiro BH.  Growth hormone-independent suppression of growth hormone-dependent female isoforms of cytochrome P450 by the somatostatin analog octreotide.  Eur J Pharmacol. Sep 5, 2013; 715(0): 256–261. PMCID: PMC375958

  • Moon, E., L.C. Wang, D.V. Dolfi, C.B. Wilson, R. Ranganathan, J. Sun, V. Kapoor, E. Puré, M.C. Milone, C.H. June, J. Riley, E.J. Wherry, S.M. Alblelda. 2014. Multifactorial T cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor transduced human T cells. Clin. Cancer Res. Epub ahead of print. PMID:24919573.

  • Dong DW, Pereira F, Barrett SP, Kolesar JE, Cao K, Damas J, Yatsunyk LA, Johnson FB, Kaufman BA. Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints. BMC Genomics. 2014 Aug 13;15(1):677 PMID:  25124333

  • Epperson CN, Kim DR, Bale TL. Estradiol modulation of monoamine metabolism: one possible mechanism underlying sex differences in risk for depression and dementia. JAMA Psychiatry. 2014 Aug 1;71(8):869-70. PMCID:  PMC4126841

  • Yildirim O, Hung JH, Cedeno RJ, Weng Z, Lengner CJ, Rando OJ. A System for Genome-Wide Histone Variant Dynamics In ES Cells Reveals Dynamic MacroH2A2 Replacement at Promoters. PLoS Genet. 2014 Aug 7;10(8):e1004515 PMCID:  PMC4125097

  • Zhou J, Goldberg EM, Leu NA, Zhou L, Coulter DA, Wang PJ. Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome. Hum Mol Genet. 2014 Jul 15;23(14):3823-9. PMCID:  PMC4065155
  • Cornachione AS, Leite FS, Wang J, Leu NA, Kalganov A, Volgin D, Han X, Xu T, Cheng YS, Yates JR 3rd, Rassier DE, Kashina A. Arginylation of myosin heavy chain regulates skeletal muscle strength.  Cell Reports. 2014 Jul 24;8(2):470-6.

  • Howerton CL, Bale TL.  Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9639-44. PMCID:  PMC4084439

  • Gray CM, McCorkell KA, Chunduru SK, McKinlay MA, May MJ.  Negative feedback regulation of NF-κB-inducing kinase is proteasome-dependent but does not require cellular inhibitors of apoptosis. Biochem Biophys Res Commun. 2014 Jul 18;450(1):341-6. PMCID:  PMC4107106

  • Habineza Ndikuyeze G, Gaurnier-Hausser A, Patel R, Baldwin AS, May MJ, Flood P, Krick E, Propert KJ, Mason NJ. A phase I clinical trial of systemically delivered NEMO binding domain peptide in dogs with spontaneous activated B-cell like diffuse large B-cell lymphoma. PLoS One. 2014 May 5;9(5):e95404 PMCID:  PMC4010398

  • Das RK, Banerjee S, Shapiro BH. Irreversible perinatal imprinting of adult expression of the principal sex-dependent drug-metabolizing enzyme CYP2C11. FASEB J. 2014 Jun 18. pii: fj.13-248864. PMCID:  PMC4139898

  • Suzuki D, Leu NA, Brice AK, Senoo M. Expression analysis of Dact1 in mice using a LacZ reporter. Gene Expr Patterns. 2014 May;15(1):21-30. PMID:  24681206

  • Maria A. Lim, Kendra K. Bence, Ishani Sandesara, Penelope Andreux, Johan Auwerx, Jeff Ishibashi, Patrick Seale, and Robert G. Kalb.  Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of Amyotrophic Lateral Sclerosis.  Human Molecular Genetics, May 15th, 2014, PMID: 24833719.

  • Howerton AR, Roland AV, Bale TL. Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation. J Neurosci. 2014 May 21;34(21):7113-23. PMCID:  PMC4028491

  • Morrison KE, Rodgers AB, Morgan CP, Bale TL. Epigenetic mechanisms in pubertal brain maturation. Neuroscience. 2014 Apr 4;264:17-24. PMCID:  PMC3959229.

  • Rukhadze I, Kalter J, Stettner GM, Kubin L. Lingual muscle activity across sleep-wake States in rats with surgically altered upper airway. Front Neurol. 2014 Apr 28;5:61. PMCID:  PMC4009435

  • Bansal S, Leu AN, Gonzalez FJ, Guengerich FP, Chowdhury AR, Anandatheerthavarada HK, Avadhani NG.  Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. J Biol Chem. 2014 Apr 4;289(14):9936-51. PMCID:  PMC3975038

  • Bhattacharya S, Katlinski KV, Reichert M, Takano S, Brice A, Zhao B, Yu Q, Zheng H, Carbone CJ, Katlinskaya YV, Leu NA, McCorkell KA, Srinivasan S, Girondo M, Rui H, May MJ, Avadhani NG, Rustgi AK, Fuchs SY. Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury.  EMBO Mol Med. 2014 Mar;6(3):384-97. PMCID:   PMC3958312

  • Gray CM, Remouchamps C, McCorkell KA, Solt LA, Dejardin E, Orange JS, May MJ. Noncanonical NF-κB signaling is limited by classical NF-κB activity. Sci Signal. 2014 Feb 4;7(311):ra13 PMCID:  PMC3960999

  • Basu A, Wilkinson FH, Colavita K, Fennelly C, Atchison ML. YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment. Nucleic Acids Res. 2014 Feb;42(4):2208-23. PMCID:  PMC3936737

  • Fu Q, Wang PJ. Mammalian piRNAs: Biogenesis, function, and mysteries. Spermatogenesis. 2014 Feb 7;4:e27889. PMCID:  PMC4114582

  • Ryan C. Tsou, Kimberly S. Rak, Derek J. Zimmer, and Kendra K. Bence.  Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor.  Molecular Metabolism,  Volume 3, issue 3, pages 301-312 (epub Jan. 2014). PMCID: PMC3986631.

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