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New Bolton Center
Research  Centers & Laboratories


Our faculty at New Bolton Center are engaged in ongoing groundbreaking research in topics ranging from Laminitis to Botulism. Here are examples of research centers and laboratories and the projects being investigated at New Bolton Center.

  • ASMG Laboratory - Microbial Genomics

    asmg-lab-new-bolton-center 500

    The Agricultural Systems and Microbial Genomics Laboratory (ASMG Laboratory) was established to support Dr. Dou and Dr. Pitta in their research endeavors.

    Dr. Pitta is the ruminant nutrition and microbiologist at the Center for Animal Health and Productivity (CAHP), New Bolton Center, University of Pennsylvania.

    Microbial Genomics

    Research in the Microbial Genomics section of the ASMG lab focuses primarily on the gut microbial composition of ruminants, utilizing both culture-based and advanced molecular methodologies. The alimentary tract of a ruminant is colonized by millions of microbes living in a symbiotic relationship with the host. Therefore, knowledge of the microbial composition of the entire gut can provide insights into improving the overall health and productivity of the animal.

    Microbiology Component

    new-bolton-center-asmg-lab-microbial-genomics 400The recent advent of next generation sequencers has greatly enhanced the ability to explore community microbial populations. The ASMG lab has the capabilities to perform metagenomic studies including sample preparation, genomic DNA extraction and generating 16S amplicon libraries for sequencing on next generation platforms. The sequenced data is analyzed at the ASMG laboratory utilizing the appropriate bioinformatics tools for data interpretation. The lab is in the process of streamlining the protocols for generating 18S libraries for protozoa and fungal communities.

     

    Read More About The ASMG Laboratory - Microbial Genomics
  • Center for Animal Health & Productivity (CAHP)

    The Center for Animal Health and Productivity (CAHP) was established in 1986 to implement teaching, research and service programs directed toward the improvement of health and productivity in food animal herds and flocks.

    These programs involve an integrated approach making use of our expertise in clinical nutrition, reproduction, health economics, and computer science, in addition to conventional specialties in veterinary medicine.

    Our focus is the maintenance of physical and economic health in the whole animal population rather than clinical treatment of individual sick animals.

    Read More About The Center for Animal Health & Productivity (CAHP)
  • Equine Pharmacology Laboratory

    Dr. Mary Robinson, Equine Pharmacology

    Our Mission: The mission of the Equine Pharmacology Laboratory at New Bolton Center is to promote the welfare of the working horse and the integrity of sport through pharmacological and forensic research.

     

    Read More About The Equine Pharmacology Laboratory
  • Marshak Dairy

    Marshak Dairy, New Bolton CenterThe Marshak Dairy is named in honor of Robert Marshak, the ninth dean of the School of Veterinary Medicine whose support was instrumental in establishing the farm. Built in 1996, the greenhouse dairy was the first of its kind and was recognized as a dairy of distinction in 1998. The greenhouse design uses natural lighting and excellent ventilation within the barn to promote a healthy environment for the cows.

    The Marshak Dairy provides an easily accessible working dairy farm for research trials. In addition, the Dairy serves as a laboratory for teaching students on topics related to cow healthcare, preventive medicine, nutrition and food safety.

    Read More About The Marshak Dairy
  • Ortved Laboratory

    The Ortved Laboratory at New Bolton Center is focused on understanding the pathophysiology of post-traumatic osteoarthritis (PTOA) and developing gene and cell-based therapies to help regenerate cartilage and prevent the development of PTOA following joint injury.

    Due to the many similarities in joint biomechanics and propensity for PTOA, our lab uses the horse as a large animal model for human joint disease. Our goal is to develop translational regenerative therapies that would benefit both the equine and human patient.

    Lab Mission

    • To improve cartilage repair using stem cell and gene therapy.
    • To limit the long-term effects of joint trauma through gene therapy immunomodulation of the joint.
    • To further elucidate the pathogenesis of post-traumatic osteoarthritis (PTOA).

    Dr. Kyla Ortved, New Bolton Center

    Interested in Working With Us?

    We are always seeking highly motivated students and post-doctoral fellows with an interest in:

    • Orthopedic research
    • Joint disease
    • Stem cell therapy
    • Gene therapy
    • Regenerative medicine
    • Cartilage biology

    Contact: Dr. Kyla Ortved at kortved@vet.upenn.edu

    Read More About The Ortved Laboratory
  • Preclinical Service Core - Comparative Orthopedic Research Laboratory

    CORL surgery, Penn Vet

    In the current medtech landscape, investors, and ultimately payers (insurance companies, hospitals and patients), require medical innovation that provides value – reducing health care costs through better clinical outcomes and/or reduced procedure costs. This means product development decisions need to be thoughtful of 1) the overall cost for developing a product and its ultimate release, as well as, 2) the value it brings.

    Appropriately aligning your product development efforts, including your preclinical testing, can make your team more efficient and ultimately increase the likelihood of a successful product. For over a decade, we have taken time to listen to you and to understand the product development plan, intended market, and the value proposition for your investigational therapy or device. Our objective is to ask the right questions in order to choose a refined preclinical model with high translational fidelity. This approach has delivered answers in the context of the intended clinical indication of your technology. Together, we have successfully moved numerous new therapies to market; and we have failed, but failing at the preclinical stage is a whole lot better than later in clinical trials.

    The Preclinical Service Core at the University of Pennsylvania School of Veterinary Medicine (Penn Vet) is focused on non-clinical and clinical (VICH-GL9) translation. Leveraging the multi-disciplinary specialties at Penn Vet, PRS & CORL provide a refined platform of successful translation using experimental and naturally-occurring disease models. We partner with pharmaceutical and medical-device companies, government agencies, and academic institutions to meet a broad range of R&D needs.

    Specialties: Preclinical study design and execution from proof-of-concept to pivotal trials compliant with the United States Food and Drug Administration (FDA) Good Laboratory Practice (GLP) Regulations, 21 CFR Part 58 and VICH-GL9. Bioskills training and prototype testing.

    Read More About The Preclinical Service Core - Comparative Orthopedic Research Laboratory
  • Reference Andrology Laboratory

    The Reference Andrology Laboratory provides complete testing of neat, cooled and frozen-thawed semen from mammalian and avian species. The primary purpose of these services is to aid practitioners in their differential diagnosis of individual/herd/flock reproductive problems.

    These services are also frequently used by practitioners and studs as a third-party quality control component in an ongoing stud auditing process.

    The laboratory strives to perform objective, validated techniques for assessing samples for the basic spermiogram parameters of sample volume, motility, morphology, and concentration. With advanced notification, we will also try to accommodate requests for supplemental assessment techniques on sperm subcellular structures. We also offer semen extender analysis and microbiological testing of the extended semen product and purified water used in extenders.

    Read More About The Reference Andrology Laboratory
  • Swine Teaching and Research Center
    Penn Vet's Swine facilityToday the US swine industry finds itself confronted with rapidly changing public opinion and policy on how gestating sows should be housed. Penn Vet is uniquely positioned to provide the industry with relevant scientific data collected from this living laboratory.
    Read More About The Swine Teaching and Research Center