In a previous study conducted here at PennVet, the mushroom supplement I’m-Yunity® significantly increased survival time in dogs with splenic hemangiosarcoma. I’m-Yunity® extract effectively delivers the standardized ingredient polysaccharopeptide (PSP) which can only be isolated from the Coriolus Versicolor mushroom. 

In this new trial, we will be comparing I’m-Yunity’s® effect on survival time and quality of life to the standard chemotherapy treatment.

Owners will be given the opportunity to choose either chemotherapy or I’m-Yunity® as treatment for their dog.  Half of the dogs getting chemotherapy will be randomly chosen to receive I'm Yunity® concurrently with the chemotherapy, and owners will not know whether or not their dog is getting I'm Yunity®.  Dogs enrolled in this study will have 11 weekly visits, followed by monthly follow-up visits until the end of their life.


  • Diagnosis of hemangiosarcoma following splenectomy.
  • At least 4 kg.
  • Not currently undergoing treatment for cancer.
  • No other significant health concerns that are an immediate threat to life.
  • Ability to administer oral medication (pills) to your dog.
Please contact the VCIC at 215-573-0302 or for more information about this study.