We are recruiting client-owned cats with diabetic ketoacidosis (DKA) to participate in a clinical study that compares the effectiveness of two different types of insulin, Lispro insulin and Regular insulin. This study is designed to compare the insulin that is the current standard of care (Regular insulin), with a newer type of insulin (Lispro insulin) that is currently used in humans and has also been used to successfully treat dogs with DKA. In the course of this study, cats will be treated for DKA in the same manner that cats not enrolled in the study would be treated for DKA except for being randomly assigned to treatment with one of the two insulins being studied. Treatment will be provided at a reduced cost, as much of the initial diagnostic testing (see below) is covered by the study. The owner will otherwise be responsible for covering costs not covered by the study. Items covered by the study include:

  • Blood work (complete blood count and chemistry screen)
  • Urinalysis
  • Urine culture
  • Thyroid level
  • Feline leukemia virus and feline immunodeficiency virus testing
  • Blood test for pancreatitis (PLI)
  • Abdominal ultrasound
  • Chest x-rays

In order to qualify for enrollment, cats must not have been started on insulin prior to enrollment, other than maintenance (intermediate- or long-acting) insulin given subcutaneously to previously diagnosed diabetics. Additional enrollment criteria include confirmation of a sufficient level of acidosis, ketosis and hyperglycemia at the time of presentation to MJR-VHUP.

This study has been approved by the University of Pennsylvania Institutional Animal Care and Use Committee (IACUC). Please contact Dr. Danielle Weinstein of the Internal Medicine Service for further details at 215-573-2376 or daniwein@vet.upenn.edu. For emergency referral, please have your veterinarian contact the MJR-VHUP Emergency Service at 215-746-8911.