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Instruments & Applications


The Penn Vet Imaging Core (PVIC) has a variety of microscopes available to meet a broad range of imaging needs.  Information on the specific instruments available in the PVIC is provided below, along with examples of some of the types of work that can be done with each of these microscopes.

Focus: Second Harmonic Generation (SHG)

Skin SHG, Volk Lab, Imaging Core

SHG microscopy was used to visualize fibrillar collagen (green) in a section of skin at the epidermal and dermal junction.

Scheduling Core Instruments

Registered users can access the PVIC online scheduler to reserve and use the Penn Vet Imaging Core instruments.

If you are not already registered, please contact the core manager.

Imaging Core Instruments


hydrogel, Imaging Core

Leica SP8 Confocal/Multiphoton Microscope

This upright laser scanning confocal microscope has 2-Photon capability, providing the added ability to perform intravital imaging and second harmonic generation (SHG) imaging.

Learn more about the SP8 Confocal/Multiphoton Microscope
Cell Mask, Penn Vet Imaging

Leica SP5-II Confocal/ Fluorescence Lifetime Imaging Microscope (FLIM)

The fully integrated PicoQuant fluorescence lifetime imaging system on this inverted laser scanning confocal microscope gives users the option of analyzing fluorescent probe distribution based on fluorescence lifetime in addition to fluorescence intensity.

Learn more about FLIM
VP40-timelapse-movie-still

Leica DMI4000 Microscope with Yokagawa CSU-X1 Spinning Disk Confocal Attachment

A full environmental enclosure, programmable motorized stage, and sensitive EM-CCD camera make this spinning disk confocal system ideal for long-term multipoint timelapse microscopy. It is also excellent for large-scale automated tile acquisition and image stitching.

Learn more about the Spinning Disk
Leishmania, Imaging Core

Leica DM6000 Widefield Fluorescence Microscope

This upright widefield microscope is equipped with both color and monochrome cameras, making it suitable for imaging either histology slides or fluorescently labeled samples.

Learn more about the Leica DM6000
TIRF microscope, Imaging Core, Penn Vet 

Leica Total Internal Reflection Fluorescence (TIRF) Microscope*

Through evanescent wave illumination that can be adjusted to penetrate as little as 70 nm, events at or near the cell membrane can be imaged with high Z-Axis resolution.

* This microscope is available by special arrangement with the laboratory of Dr. Bruce Freedman.  Please contact Dr. Freedman or the core manager directly to schedule use of the TIRF microscope.

Learn more about the TIRF System
PVIC stereo microscope Nikon SMZ1000

Additional Equipment Available

The ring light and camera mount on this microscope make it possible to acquire images of small opaque objects, such as a small insect. This stereo microscope is also available to aid in dissection or microsurgery when needed to prepare samples for live imaging on the 2-Photon microscope.

Learn more about the Nikon SMZ1000 Stereo Microscope
PVIC incubator

New Brunswick Galaxy 48-S CO2 Incubator

For the convenience of those imaging live cells in culture, this small incubator is available for maintaining cells prior to imaging.

Learn more about the Nikon SMZ1000 Stereo Microscope