Here are a selection of recent publications for the Avadhani Laboratory. For a comprehensive list, please visit Dr. Avadhani's PubMed Link.
1: Bansal S, Anandatheerthavarada HK, Prabu GK, Milne GL, Martin MV, Guengerich FP, Avadhani NG. Human Cytochrome P450 2E1 Mutations That Alter MitochondrialTargeting Efficiency and Susceptibility to Ethanol-induced Toxicity in Cellular Models. J Biol Chem. 2013 May 3;288(18):12627-44
2: Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK,Martin MV, Guengerich FP, Avadhani NG. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. J Biol Chem. 2013 Feb 8;288(6):4436-51.
3: Sleeper MM, Rosato BP, Bansal S, Avadhani NG. Mitochondrial dysfunction in
myocardium obtained from clinically normal dogs, clinically normal anesthetized dogs, and dogs with dilated cardiomyopathy. Am J Vet Res. 2012
4: Srinivasan S, Avadhani NG. Cytochrome c oxidase dysfunction in oxidative
stress. Free Radic Biol Med. 2012 Sep 15;53(6):1252-63.
5: Tang W, Chowdhury AR, Guha M, Huang L, Van Winkle T, Rustgi AK, Avadhani NG.Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo. Carcinogenesis. 2012 Sep;33(9):1762-8.
6: Bansal S, Srinivasan S, Anandasadagopan S, Chowdhury AR, Selvaraj V, Kalyanaraman B, Joseph J, Avadhani NG. Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes. J Biol Chem. 2012 May 4;287(19):15284-97.
7: Ren L, Hong SH, Chen QR, Briggs J, Cassavaugh J, Srinivasan S, Lizardo MM,
Mendoza A, Xia AY, Avadhani N, Khan J, Khanna C. Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma. Cancer Res. 2012 Feb 15;72(4):1001-12.
8: Avadhani NG. Targeting of the same proteins to multiple subcellular destinations: mechanisms and physiological implications. FEBS J. 2011 Nov;278(22):4217
9: Avadhani NG, Sangar MC, Bansal S, Bajpai P. Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals. FEBS J. 2011 Nov;278(22):4218-29.
10: Yan C, Avadhani NG, Iqbal J. The effects of smoke carcinogens on bone. Curr Osteoporos Rep. 2011 Dec;9(4):202-9.
11: Raza H, Prabu SK, John A, Avadhani NG. Impaired mitochondrial respiratory
functions and oxidative stress in streptozotocin-induced diabetic rats. Int J Mol Sci. 2011;12(5):3133-47.