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Science & Research News


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Penn Vet Team Shows a Protein Modification Determines Enzyme’s Fate

The human genome encodes roughly 20,000 genes, only a few thousand more than fruit flies. The complexity of the human body, therefore, comes from far more than just the sequence of nucleotides that comprise our DNA, it arises from modifications that occur at the level of gene, RNA and protein.

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Disrupting Cells’ ‘Powerhouses’ Can Lead to Tumor Growth, Penn Study Finds

Cancer cells defy the rules by which normal cells abide. They can divide without cease, invade distant tissues and consume glucose at abnormal rates.

A biopsy of an infertile man's testis shows the precursors of sperm, but no mature sperm.

Penn Team Identifies Gene Responsible for Some Cases of Male Infertility

In the most severe form of male infertility, men do not make any measurable levels of sperm. This condition, called azoospermia, affects approximately 1 percent of the male population and is responsible for about a sixth of cases of male infertility.

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Penn Vet Research Confirms a More Accurate Method for Blood Glucose Testing

For diabetics, a quick prick of the finger can give information about their blood glucose levels, guiding them in whether to have a snack or inject a dose of insulin. Point-of-care glucose meters, or glucometers, are also used in the veterinary world to monitor cats and dogs with diabetes or pets hospitalized for other reasons. In both cases, the device’s readout can literally be a matter of life and death.

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New Bolton Center Researchers Study Effect of Equine Microbiome on Colic

The role of the equine microbiome in colic is the focus of new research at Penn Vet’s New Bolton Center.

Researchers are analyzing microbiome data from horses undergoing surgery, comparing horses given antimicrobials to horses that were not given antimicrobials. Preliminary data shows antimicrobials have a significant effect on the equine microbiome.


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Penn Study Identifies Molecular Link Between DNA Damage and Premature Aging

Like a beloved pair of jeans, human DNA accumulates damage over time, and older people’s bodies can’t repair it as well. Many scientists believe a build up of damage can cause cells to enter an irreversible dormant state known as senescence. Cellular senescence is believed to be responsible for some of the telltale signs of aging, such as weakened bones, less resilient skin and slow-downs in organ function.

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Penn Vet, Montreal and McGill Researchers Show How Blood-Brain Barrier Is Maintained

The brain is a privileged organ in the body. So vital to life, the brain is protected from alterations elsewhere in the body by a highly regulated gateway known as the blood-brain barrier, which allows only selected molecules to pass through.

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One Health - Penn Vet’s Collection of 50,000 Salmonella Strains

The 50,000 glass vials locked away in a building on Penn Vet’s New Bolton Center campus hold the keys to new research into Salmonella, the number-one cause of foodborne illness in the United States.  Read this story...

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Penn Scientists Describe the Function of an Enzyme Critical to Male Fertility

Researchers are one step closer to unraveling the extraordinarily complex series of processes that lead to an event crucial to human reproduction: the creation of sperm.

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Penn Vet Researchers Identify Effective Treatment for Niemann Pick Type C

Niemann Pick Disease type C, or NPC, is a disease most people have never heard of, affecting just one person in 150,000. Yet the disease is a devastating one. Frequently diagnosed in children in their elementary school years, sufferers usually die by the time they’re 20. The disease is sometimes referred to as “childhood Alzheimer’s” because of the progressive mental and physical decline seen in the children it afflicts.

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About Equine Blood Transfusion Crossmatching

New Bolton Center’s Dr. Rose Nolen-Walston conducted two separate studies on blood transfusions in horses.

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Mosquitoes Ramp Up Immune Defenses After Sucking Blood

If you were about to enter a crowded subway during flu season, packed with people sneezing and coughing, wouldn’t it be helpful if your immune system recognized the potentially risky situation and bolstered its defenses upon stepping into the train?

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The “Barth” Memorial Fund for Mitral Valve Disease Research Established at Penn Vet

A $450,000 gift from Bruce Wiltsie and William Davenport will support Penn Vet research in the treatment of canine Mitral Valve Disease (MVD). Named in honor of their beloved dog, Barth, who passed away from MVD, the “Barth” Memorial Fund for Mitral Valve Disease Research will enable experts at Penn Vet to investigate new medications to stop or reverse the process of the disease. This work also has important implications for non-surgical treatment of MVD in people.