Immunotherapies have revolutionized treatment for people with a variety of cancers. But when given to those with triple-negative breast cancer (TNBC), a particularly aggressive form of the disease, less than 20% respond.
While some of our body’s cells divide in a matter of hours, the process of making sperm, meiosis, alone takes about 14 days from start to finish. And fully six of those days are spent in the stage known as the pachytene, when pairs of chromosomes from an individual’s mother and father align and connect.
Researchers at the University of Pennsylvania’s School of Veterinary Medicine (Penn Vet) today announced the launch of a novel study exploring possible effects resulting from the combined use of furosemide, commonly known as Lasix, and bisphosphonates in equine athletes.
They know their names. We can read their facial expressions, sort of. And some of them really like having us around. These are among the purported findings of recent scientific studies aimed at deciphering the behavior of some of our most mysterious yet ubiquitous companions: pet cats.
While many immunologists use mouse models to conduct their research, J. Oriol Sunyer of Penn’s School of Veterinary Medicine has made transformational scientific insights using a very different creature: rainbow trout.
Radiation therapy to treat cancer can be grueling, requiring consecutive days of therapy over days or weeks. "When you talk to patients about coming in for 35 treatments, or seven weeks of daily therapy, usually their face kind of sags in disappointment or perhaps apprehension,” says Keith Cengel, a radiation oncologist at Penn’s Perelman School of Medicine.
When wildlife biologist Matthew Schnupp began his career, the emphasis was on conserving habitat. “The paradigm of wildlife management for the last 20 years has been habitat management,” he says, aiming to conserve the land and ecosystems animals require to thrive.
The threadlike parasite Dirofilaria immitis causes the debilitating canine heartworm disease. A related parasite, Brugia malayi, infects humans and is one of the parasites responsible for lymphatic filariasis, a neglected disease that affects 120 million and can give rise to elephantiasis, characterized by disfiguring and painful swollen limbs.
Until a month ago, it’s possible to never have heard of coronavirus, despite the fact that science has known about this family of seven viruses since the 1960s. Four are common, causing mild or moderate respiratory symptoms like a runny nose and sore throat, all of which dissipate quickly.
Toxoplasma gondii is best known as the parasite that may lurk in a cat’s litter box. Nearly a third of the world’s population is believed to live with a chronic Toxoplasma infection. It’s of greatest concern, however, to people with suppressed immune systems and to pregnant women, who can pass the infection to their fetuses.
More sure-footed and confident by the day, the U litter puppies of the Working Dog Center are not yet 3 months old, yet are already a month into their training to use their agile bodies and sensitive noses to serve society.
These changes require energy. In a study using a new, genetically altered mouse model, researchers led by Rumela Chakrabarti of Penn’s School of Veterinary Medicine have uncovered a key protein involved in supplying the mammary gland with fuel during puberty. It’s a protein that her group had earlier shown to play a role in triple-negative breast cancer (TNBC), a particularly aggressive form of the disease
A treatment called extracorporeal shockwave therapy (ESWT) is used in patients both human and equine to speed healing of injured tendons and ligaments. Using high-pressure sonic waves, ESWT is thought to increase blood flow to the treated area, and has been shown to reduce pain over the short term.
[December 9, 2019; PHILADELPHIA, PA – Three researchers from the School of Veterinary Medicine at the University of Pennsylvania (Penn Vet) are among the recipients of the annual Innovation awards from the Penn Center for Innovation (PCI), which recognizes the six most significant scientific discoveries or partnerships at the University of Pennsylvania during the preceding twelve months.
For patients with cutaneous leishmaniasis, a skin infection transmitted by a sand fly that can lead to painful and disfiguring ulcers, treatment can be grueling. The first-line therapy offered to many requires daily infusions of the metalloid pentavalent antimony for three weeks, and half of patients don’t respond to just one round of therapy. Some fail two or even three courses. And the side effects of therapy can range from mere irritation to far more serious conditions.
Dogs that are spayed at a young age have a reduced risk of developing mammary tumors, the canine equivalent of breast cancer. Early spaying reduces levels of estrogen production, leading many veterinarians and scientists to cast estrogen in a negative light when it comes to mammary cancer.
Penn Vet and the Pennsylvania Game Commission (PGC) recently initiated the Pennsylvania Wildlife Futures Program (WFP), a new science-based, wildlife health program that will increase disease surveillance, management and innovative research aimed at better protecting wildlife across the Commonwealth.
Given the dazzling array of dog breeds, from dachshunds to mastiffs, from poodles to bloodhounds, it’s easy to forget that most of that diversity arose only in the last few centuries or so, thanks to human tinkering. People have bred dogs for their looks, but the lion’s share of breeding efforts have taken aim at eliciting particular behaviors, according to the University of Pennsylvania’s James A. Serpell.
Creating an effective gene therapy for inherited diseases requires three key steps. First, scientists must identify and characterize the disease. Second, they must find the gene responsible. And finally, they must find a way to correct the impairment.
[PHILADELPHIA, September 12, 2019] - A new core facility, the first on the east coast to exclusively focus on the isolation and characterization of extracellular vesicles, has opened at the University of Pennsylvania’s School of Veterinary Medicine (Penn Vet). The Extracellular Vesicle Core Facility at Penn Vet supports investigators with the necessary scientific and technical capabilities to define, standardize and monitor research in pathological and physiological conditions.