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Cooler temps and northern climes associated with increased diabetes diagnoses in dogs

By: Katherine Unger Baillie | Kbaillie@Upenn.Edu | 215-898-9194 Date: Aug 16, 2022
A team from Penn Vet has identified an association between colder weather and climates and diabetes diagnoses in dogs. A parallel link is seen in diagnoses of Type 1 diabetes in people.
A team from Penn Vet has identified an association between colder weather and climates and diabetes diagnoses in dogs. A parallel link is seen in diagnoses of Type 1 diabetes in people.

In people, Type 1 diabetes mellitus diagnoses are more common in northern latitudes and during winter. Now a new study shows a similar pattern in dogs.

The research, published in the journal PLOS ONE,  looked at 960 pet dogs with diabetes mellitus living across the United States. A team of University of Pennsylvania School of Veterinary Medicine researchers found that diabetes diagnoses were significantly more likely to occur in the winter and in the northern U.S. compared to any other season or region. Though the findings don’t explain the underlying cause of this correlation, the link with cold weather hints at future possibilities to pursue.

Dr. Rebecka Hess, Penn Vet
Dr. Rebecka Hess

“This link is something that has been discussed in regard to humans with Type 1 diabetes, but it’s never been rigorously looked at in dogs,” says Rebecka Hess, a professor at Penn Vet and senior author on the study. “It’s important to explore because dogs and people live in the same world. If the environment—cold temperatures and seasonality—are important in this disease in both species, it gives us something to look at with further research.”

To investigate the relationships between geography, seasonality, and diabetes, Hess and Penn Vet colleagues recruited dogs with the condition from across the U.S., reaching out to all of the nation’s veterinary schools, the American Kennel Club, and breed clubs and leveraging social media to gain the broadest sample possible. Owners filled out surveys about their pets, including their dog’s age, date and age at the time of diabetes diagnosis, and state of residence.

For 669 dogs, the date of diabetes diagnosis was known. Of those, 33% were diagnosed in the winter, compared to 24% in the spring, 24% in the summer, and 19% in the fall. When the research team looked at geographic regions of the U.S., the North stood out, with 46% of diagnoses occurring in dogs in this region, compared to 27% in the South, 15% in the central U.S., and 12% in the West. This is despite the fact that many more dogs—more than 31 million—reside in the South compared to about 24 million in the North and about 13 million each in the central and West regions.

“To be honest, I was surprised we found this connection, even though it had been hinted at before. I was always skeptical of the data,” says Hess. “But when I saw our results, it was quite clear. The findings were strengthened by the fact that diabetes diagnoses were more prevalent in both the winter and the North. Results would have been more difficult to interpret if, for example, we had found increased prevalence in the winter but also in the South.”

Three percent of the dogs in the study developed diabetes before they were 1 year of age. Like the diagnoses made in adulthood, these juvenile-onset cases were also more common in colder months and in the North but did not correlate to any particular breed, the researchers found.

Hypotheses about the connection between colder and more northerly climates and diabetes diagnoses in humans include links to vitamin D deficiency, diet, lifestyle, and viral infections. In dogs, the diet connection seems unlikely, Hess says, as most dog owners feed their pets a commercially available kibble, no matter their location or the season. In addition, she says, overweight and obese dogs aren’t at higher risk of developing diabetes, so a connection with exercise, or lack thereof, seems unlikely.

In Hess’ view, the culprits are more likely to involve how the body processes either vitamin D or insulin. In human studies, lower levels of vitamin D have been connected with an increased likelihood of diabetes. And lower temperatures lead to declines in insulin sensitivity. Hess also says some researchers have floated a connection to a viral infection that may be more prevalent in cold weather.

In future work, Hess says she hopes to delve into the vitamin D connection, perhaps exploring how genetic variability in the vitamin D receptor correlates with diabetes risk. A study that examines a prior history of viral infection could also be revealing, she says.

“Given the close relationship between humans and dogs, and the parallels we see when it comes to diabetes, it behooves us to look.”

Rebecka S. Hess is a professor of internal medicine in the University of Pennsylvania School of Veterinary Medicine.

Hess’s coauthors on the work were Penn Vet’s Liang N. Y. Qiu, Stephen V. Cai, and Dennis Chan. 

A private donor supported the work.

About Penn Vet

Ranked among the top ten veterinary schools worldwide, the University of Pennsylvania School of Veterinary Medicine (Penn Vet) is a global leader in veterinary education, research, and clinical care. Founded in 1884, Penn Vet is the first veterinary school developed in association with a medical school. The school is a proud member of the One Health initiative, linking human, animal, and environmental health.

Penn Vet serves a diverse population of animals at its two campuses, which include extensive diagnostic and research laboratories. Ryan Hospital in Philadelphia provides care for dogs, cats, and other domestic/companion animals, handling more than 34,600 patient visits a year. New Bolton Center, Penn Vet’s large-animal hospital on nearly 700 acres in rural Kennett Square, PA, cares for horses and livestock/farm animals. The hospital handles more than 6,200 patient visits a year, while our Field Services have gone out on more than 5,500 farm service calls, treating some 18,700 patients at local farms. In addition, New Bolton Center’s campus includes a swine center, working dairy, and poultry unit that provide valuable research for the agriculture industry.