Parasitology Seminar Series
Title: “Environmental and genetic determinants of malaria transmission"
Speaker: Matthias Marti, PhD
Professor of Molecular Parasitology
Wellcome Centre for Integrative Parasitology
Institute of Infection, Immunity and Inflammation,
College of Medical Veterinary & Life Sciences,
University of Glasgow, Scotland
Date: Monday, November 30, 2020
Time: 12 - 1 pm
Malaria parasites have coevolved with humans over thousands of years, mirroring their migration out of Africa. They persist to this day, despite continuous elimination efforts worldwide. Life-history theory predicts that parasites can adjust investment into (within-host) replication versus (between-host) transmission, dependent on the environmental conditions. Studies in P. falciparum revealed that epigenetic mechanisms regulate the plasticity in sexual conversion rates (i.e. the proportion in a given asexual cohort that produce sexual, transmissive progeny) in response to changes in the within-host environment. Given the spread and persistence of malaria parasites across a wide range of transmission settings, it is likely that the sexual conversion rate is also be subject to natural selection. I will present data demonstrating that both environmental and genetic factors contribute to the regulation of malaria transmission.
Questions: Please contact Sue Waddington-Pilder (firstname.lastname@example.org).