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Research Briefs

Published: May 6, 2013

Grants

David Artis, PhD, associate professor, has received three grants totaling more than $4 million, including a $225,000 National Institutes of Health grant for “Regulation of protective immunity following enteric viral infection;” a $2 million, five-year grant to study the “Regulation of protective immunity following enteric viral infection;” and a $1.8 million grant to study “Regulation and function of innate lymphoid cells in the gut.”

Ashley Boyle, DVM, assistant professor of medicine in field service, was recently awarded two grants. The first was awarded by the American Quarter Horse Foundation for a one-year investigation into the “Verification of a Streptococcus equi detection assay for equine nasopharyngeal and guttural pouch wash samples.” The second is to study the “Prevalence and strain characterization of methicillin resistant Staphylococcus aureus (MRSA) from equine nasopharyngeal and guttural pouch wash samples” and was awarded by the Equine Research Endowment Grants, Department of Clinical Studies New Bolton Center.

Ralph Brinster, VMD, PhD, Richard King Mellon Professor of Reproductive Physiology, has been awarded a three-year, $156,000 grant from the St. Baldricks Foundation for his work on “Translating the Science of Testicular Tissue Cryopreservation.”

Serge Fuchs, PhD, professor of cell biology, has been awarded a five-year, $1.29 million National Institutes of Health grant to study the “Role of HOS in Cell Transformation and Apoptosis.”

Brett A. Kaufman, PhD, assistant professor, has been awarded a $100,000 grant from the Trustees of the W.W. Smith Charitable Trust for “Mitochondrial DNA Damage and the Progression Toward Heart Failure.”

Cynthia Otto, DVM, PhD, associate professor of critical care and director of the Penn Vet Working Dog Center, has received a $100,000 grant from the American Kennel Club AKC Companion Animal Recovery Detection Dog DNA Bank.

Nicola Mason, PhD, assistant professor, has received a two-year, $108,527 grant from the Morris Animal Foundation to study “Development of a CD20-specific antibody fragment for targeted therapy of canine B cell lymphoma.”

Recent Publications

Bish LT, Sleeper MM, Forbes SC, Morine KJ, Reynolds C, Singletary GE, Trafny D, Pham J, Bogan J, Kornegay JN, Vandenborne K, Walter GA, Sweeney. HL Long-Term Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Golden Retriever Muscular Dystrophy. (2011) Hum Gene Ther., Aug 30. [Epub ahead of print].

Guziewicz KE, Slavik J, Lindauer SJ, Aguirre GD, Zangerl B. Molecular consequences of BEST1 gene mutations in canine multifocal retinopathy predict functional implications for human bestrophinopathies. Invest Ophthalmol Vis Sci. 2011 Jun 23;52(7):4497-505.

John B, Ricart B., Harris TH, Tait ED, Randall L, Weninger W, Hammer DA, Hunter CA. 2011. Analysis of behaviour and trafficking of dendritic cells within the brain during Toxo-plasmicencephalitis. (2011) PloS Pathogens. 7(9):e1002246.

Littman MP. A Matter of Opinion: Should we treat asymptomatic, nonproteinuric Lyme-seropositive dogs with antibiotics? Clinician’s Brief 2011;9:13-16.

Lopez C, Tamar Hermesh (2011). Systemic responses during local viral infections: type I IFNs sound the alarm. Current Opinion in Immunology 23(4): 495-499.

Monticelli, LA, Sonnenberg, GF, Abt, MC, Alenghat, T, Ziegler, CGK, Doering, TA, Angelosanto, JM, Laidlaw, BJ, Yang, CY, Sathaliyawala, T, Kubota, M, Turner, D, Diamond, JM, Goldrath, AW, Farber, DL, Collman, RG, Wherry, EJ, Artis, D (2011). Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol doi:10.1038.ni.2131.

Siracusa, MC, Comeau, MR, Artis D (2011). New insights into basophil biology: initiators, regulators, and effectors of type 2 inflammation. Ann N Y Acad Sci.1217:166-77. PMID: 21276006.

Slade DJ, Lees GE, Berridge BR, Clubb FJ, Kuczynski LA, Littman MP. Resolution of a proteinuric nephropathy associated with Babesia gibsoni infection in a dog. J Am Anim Hosp Assoc 2011;47:e138-e144.

Sonnenberg, GF, Fouser LA, Artis D (2011). Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat Immunol. 12(5):383-90. PMID: 21502992.

Sorenmo, KU, Krick E, Coughlin CM, Overley B, Gregor TP, Vonderheide RH, Mason, NJ. CD40- activated B cell cancer vaccine improves second clinical remission and survival in privately owned dogs with Non- Hodgkin’s Lymphoma. (2011) PLoS one 6(8): 1-8.

Vite CH, Wang P, Patel RT, Walton RM, Walkley SU, Sellers RS, Ellinwood NM, Cheng AS, White JT, O’Neill CA, Haskins M. Bio-distribution and pharmacodynamics of recombinant human alpha-L-iduronidase (rhIDU) in mucopoly-saccharidosis type I- affected cats following multiple intrathecal administrations. (2011) Mol Genet Metab. 103(3):268-74.

R J. Whitmarsh, CM. Gray, B Gregg1, DA Christian, M J May, PJ. Murray, and CA Hunter. A critical role for SOCS3 in innate resistance to Toxoplasma gondii. (2011) Cell Host Microbe, 10(3):224-36.