New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA


Diplomate, ACVIM (Neurology)

Professor of Neurology, University of Pennsylvania School of Veterinary Medicine

Research Areas: Epilepsy Feline and Canine models of neurodegenerative diseases Niemann-Pick type C disease Globoid cell leukodystrophy (Krabbe disease) Neurodegenerative diseases Neurology Neuroscience

Contact Information:
Section of Neurology & Neurosurgery
Department of Clinical Sciences and Advanced Medicine
School of Veterinary Medicine
University of Pennsylvania
3900 Delancey Street

The focus of my lab is to improve the characterization and treatment of neurological diseases by studying naturally-occurring feline and canine models of human diseases. Our lab develops and identifies ante mortem biochemical and nuclear magnetic resonance markers of disease severity and progression and uses these markers to evaluate the efficacy of gene therapy, cell-based therapy, and pharmacotherapy to treat disease.
We currently maintain breeding colonies that produce cats affected with Niemann-Pick type C disease and alpha-mannosidosis, and dogs affected with globoid cell leukodystrophy and mucopolysaccharidoses. We also maintain dogs with naturally occurring epilepsy for which we are evaluating neurophysiologically-based response pharmacotherapy using intracranially EEG. The goal of this work is to develop methods to predict seizure occurrence and to prevent them. We will implant devices and maintain epileptic dogs proposed for use in this study.

My interests focus on diseases of the brain including epilepsy, neurodegenerative processes, and neurodevelopmental processes. My clinical expertise focuses on improving the diagnosis of disease using nuclear magnetic resonance methods and clinical trials to assess the efficacy of new therapies for currently untreatable disease. I also have specific interests in epilepsy, vestibular dysfunction and myotonia congenita.

Swain, G P. Prociuk, M. Bagel, J H. O'Donnell, P. Berger, K. Drobatz, K. Gurda, B L. Haskins, M E. Sands, M S. Vite, C H. Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain. Gene Therapy 21: 28-36, 2014.

Howbert, J Jeffry. Patterson, Edward E. Stead, S Matt. Brinkmann, Ben. Vasoli, Vincent. Crepeau, Daniel. Vite, Charles H. Sturges, Beverly. Ruedebusch, Vanessa. Mavoori, Jaideep. Leyde, Kent. Sheffield, W Douglas. Litt, Brian. Worrell, Gregory A. Forecasting seizures in dogs with naturally occurring epilepsy. PLoS ONE [Electronic Resource] 9: e81920, 2014.

Coles, Lisa D. Patterson, Edward E. Sheffield, W Douglas. Mavoori, Jaideep. Higgins, Jason. Michael, Bland. Leyde, Kent. Cloyd, James C. Litt, Brian. Vite, Charles. Worrell, Gregory A. Feasibility study of a caregiver seizure alert system in canine epilepsy. Epilepsy Research 106: 456-60, 2013.

Fan, Martin. Sidhu, Rohini. Fujiwara, Hideji. Tortelli, Brett. Zhang, Jessie. Davidson, Cristin. Walkley, Steven U. Bagel, Jessica H. Vite, Charles. Yanjanin, Nicole M. Porter, Forbes D. Schaffer, Jean E. Ory, Daniel S. Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling. Journal of Lipid Research 54: 2800-14, 2013.

Bagel, Jessica H. Sikora, Tracey U. Prociuk, Maria. Pesayco, Jill P. Mizisin, Andrew P. Shelton, G Diane. Vite, Charles H. Electrodiagnostic testing and histopathologic changes confirm peripheral nervous system myelin abnormalities in the feline model of niemann-pick disease type C. Journal of Neuropathology & Experimental Neurology 72: 256-62, 2013.

Roszell, Blair R. Tao, Jian-Qin. Yu, Kevin J. Gao, Ling. Huang, Shaohui. Ning, Yue. Feinstein, Sheldon I. Vite, Charles H. Bates, Sandra R. Pulmonary abnormalities in animal models due to Niemann-Pick type C1 (NPC1) or C2 (NPC2) disease. PLoS ONE [Electronic Resource] 8: e67084, 2013.

Porter, Forbes D. Scherrer, David E. Lanier, Michael H. Langmade, S Joshua. Molugu, Vasumathi. Gale, Sarah E. Olzeski, Dana. Sidhu, Rohini. Dietzen, Dennis J. Fu, Rao. Wassif, Christopher A. Yanjanin, Nicole M. Marso, Steven P. House, John. Vite, Charles. Schaffer, Jean E. Ory, Daniel S. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Science Translational Medicine 2: 56ra81, 2010.

Ward, Sarah. O'Donnell, Patricia. Fernandez, Steven. Vite, Charles H. 2-hydroxypropyl-beta-cyclodextrin raises hearing threshold in normal cats and in cats with Niemann-Pick type C disease. Pediatric Research 68: 52-6, 2010.

Malik, Saafan Z. Lewis, Melissa. Isaacs, Alison. Haskins, Mark. Van Winkle, Thomas. Vite, Charles H. Watson, Deborah J. Identification of the rostral migratory stream in the canine and feline brain. PLoS ONE [Electronic Resource] 7: e36016, 2012.

Stein, Veronika M. Crooks, Alexandra. Ding, Wenge. Prociuk, Maria. O'Donnell, Patricia. Bryan, Caroline. Sikora, Tracey. Dingemanse, Jasper. Vanier, Marie T. Walkley, Steven U. Vite, Charles H. Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C. Journal of Neuropathology & Experimental Neurology 71: 434-48, 2012.

B.S. Cornell University, 1986

DVM Purdue University, 1990

PhD University of Pennsylvania, 2003

Diplomate, ACVIM (Neurology)

Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania. (1992 to 1994)
Resident, Veterinary Neurology

School of Medicine, University of Pennsylvania. (1994 to 1994)
Introductory Magnetic Resonance Visiting Fellowship

School of Medicine, University of Pennsylvania. (1996 to 1996)
Neuro Magnetic Resonance Visiting Fellowship

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA. (1997 to 1998)
Post-Doctoral Fellow