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New Bolton Center Kennett Square, PA
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Ryan Hospital Philadelphia, PA
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215-746-8911
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KARIN U. SORENMO, , ,

Professor, Oncology, University of Pennsylvania School of Veterinary Medicine

American College of Veterinary Internal Medicine (Oncology)

European College of Veterinary Internal Medicine-CA (oncology)

Clinical Specialties: Medical Oncologist, Chemotherapy,
Research Areas: Canine cancer, Mammary and prostatic cancers, Cancer, Canine hemangiosarcoma, Oncology,

Contact Information:
3900 Delancey Street

Karin Sorenmo: Research interest and clinical skills: As a practicing veterinary oncologist my research interests span across a relatively wide range of cancers, both in dogs and cats, for which there is currently insufficient understanding of the biological behavior and/or inadequate treatments available. The focus of my clinical research and publications so far include characterization of mammary and prostatic cancers and these tumors’ hormonal association, canine hemangiosarcoma; and more lately I have focused on immunotherapy and how to utilize cancer vaccines in animals with naturally occurring tumors. Spontaneous diseases including cancer in dogs and cats are unique resources in cancer research and can be utilized to study cancer biology and the response to novel therapies in natural, immuno-competent, realistic and relevant tumor models. Such research provides our veterinary patients access to new and potentially effective treatments while providing human cancer research reliable information for their patients. The oncology section in currently actively engaged is several of these types of collaborative trials both with colleagues at the medical school as well as other academic institutions.

Gillem Julie Marie, Sullivan Louise, Sorenmo Karin U Diagnosis and Multimodal Treatment of Metastatic Maxillofacial Juvenile Embryonal Rhabdomyosarcoma in a Young Golden Retriever. Journal of the American Animal Hospital Association 54: e54505, 2018.

Evans B J, O'Brien D, Allstadt S D, Gregor T P, Sorenmo K U Treatment outcomes and prognostic factors of feline splenic mast cell tumors: A multi-institutional retrospective study of 64 cases. Veterinary and comparative oncology 16: 20-27, 2018.

Raposo-Ferreira Talita M M, Brisson Becky K, Durham Amy C, Laufer-Amorim Renee, Kristiansen Veronica, Puré Ellen, Volk Susan W, Sorenmo Karin Characteristics of the Epithelial-Mesenchymal Transition in Primary and Paired Metastatic Canine Mammary Carcinomas. Veterinary pathology 55: 622-633, 2018.

Krick Erika Lauren, Kiupel Matti, Durham Amy C, Thaiwong Tuddow, Brown Dorothy C, Sorenmo Karin U Investigating Associations Between Proliferation Indices, C-kit, and Lymph Node Stage in Canine Mast Cell Tumors. Journal of the American Animal Hospital Association 53: 258-264, 2017.

Case Ashley, Brisson Becky K, Durham Amy C, Rosen Suzanne, Monslow James, Buza Elizabeth, Salah Pascale, Gillem Julie, Ruthel Gordon, Veluvolu Sridhar, Kristiansen Veronica, Puré Ellen, Brown Dorothy C, Sørenmo Karin U, Volk Susan W Identification of prognostic collagen signatures and potential therapeutic stromal targets in canine mammary gland carcinoma. PloS one 12: e0180448, 2017.

Kristiansen V M, Peña L, Díez Córdova L, Illera J C, Skjerve E, Breen A M, Cofone M A, Langeland M, Teige J, Goldschmidt M, Sørenmo K U Effect of Ovariohysterectomy at the Time of Tumor Removal in Dogs with Mammary Carcinomas: A Randomized Controlled Trial. Journal of veterinary internal medicine 30: 230-41, 2016.

Culp W T N, Weisse C, Berent A C, Reetz J A, Krick E L, Jackson D E, Kass P H, Clifford C A, Sorenmo K U Early tumor response to intraarterial or intravenous administration of carboplatin to treat naturally occurring lower urinary tract carcinoma in dogs. Journal of veterinary internal medicine 29: 900-7, 2015.

Donnelly L, Mullin C, Balko J, Goldschmidt M, Krick E, Hume C, Brown D C, Sorenmo K Evaluation of histological grade and histologically tumour-free margins as predictors of local recurrence in completely excised canine mast cell tumours. Veterinary and comparative oncology 13: 70-6, 2015.

Gaeta R, Brown D, Cohen R, Sorenmo K Risk factors for development of sterile haemorrhagic cystitis in canine lymphoma patients receiving oral cyclophosphamide: a case-control study. Veterinary and comparative oncology 12: 277-86, 2014.

Britton B M, Kelleher M E, Gregor T P, Sorenmo K U Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997-2010). Veterinary and comparative oncology 12: 266-76, 2014.

Flood-Knapik K E, Durham A C, Gregor T P, Sánchez M D, Durney M E, Sorenmo K U Clinical, histopathological and immunohistochemical characterization of canine indolent lymphoma. Veterinary and comparative oncology 11: 272-86, 2013.

Krick Erika L, Sorenmo Karin U, Rankin Shelley C, Cheong Ian, Kobrin Barry, Thornton Katherine, Kinzler Kenneth W, Vogelstein Bert, Zhou Shibin, Diaz Luis A Evaluation of Clostridium novyi-NT spores in dogs with naturally occurring tumors. American journal of veterinary research 73: 112-8, 2012.

Krick Erika L, Moore Reneé H, Cohen Rachel B, Sorenmo Karin U Prognostic significance of weight changes during treatment of feline lymphoma. Journal of feline medicine and surgery 13: 976-83, 2011.

Sorenmo Karin U, Krick Erika, Coughlin Christina M, Overley Beth, Gregor Thomas P, Vonderheide Robert H, Mason Nicola J CD40-activated B cell cancer vaccine improves second clinical remission and survival in privately owned dogs with non-Hodgkin's lymphoma. PloS one 6: e24167, 2011.

Hume Carrie Tupper, Kiupel Matti, Rigatti Lora, Shofer Frances S, Skorupski Katherine A, Sorenmo Karin U Outcomes of dogs with grade 3 mast cell tumors: 43 cases (1997-2007). Journal of the American Animal Hospital Association 47: 37-44, 2011.

Sorenmo K U, Rasotto R, Zappulli V, Goldschmidt M H Development, anatomy, histology, lymphatic drainage, clinical features, and cell differentiation markers of canine mammary gland neoplasms. Veterinary pathology 48: 85-97, 2011.

Wiley J L, Rook K A, Clifford C A, Gregor T P, Sorenmo K U Efficacy of doxorubicin-based chemotherapy for non-resectable canine subcutaneous haemangiosarcoma. Veterinary and comparative oncology 8: 221-33, 2010.

Sorenmo Karin, Overley B, Krick E, Ferrara T, LaBlanc A, Shofer F Outcome and toxicity associated with a dose-intensified, maintenance-free CHOP-based chemotherapy protocol in canine lymphoma: 130 cases. Veterinary and comparative oncology 8: 196-208, 2010.

Webster J D, Dennis M M, Dervisis N, Heller J, Bacon N J, Bergman P J, Bienzle D, Cassali G, Castagnaro M, Cullen J, Esplin D G, Peña L, Goldschmidt M H, Hahn K A, Henry C J, Hellmén E, Kamstock D, Kirpensteijn J, Kitchell B E, Amorim R L, Lenz S D, Lipscomb T P, McEntee M, McGill L D, McKnight C A, McManus P M, Moore A S, Moore P F, Moroff S D, Nakayama H, Northrup N C, Sarli G, Scase T, Sorenmo K, Schulman F Y, Shoieb A M, Smedley R C, Spangler W L, Teske E, Thamm D H, Valli V E, Vernau W, von Euler H, Withrow S J, Weisbrode S E, Yager J, Kiupel M Recommended guidelines for the conduct and evaluation of prognostic studies in veterinary oncology. Veterinary pathology 48: 7-18, 2011.

Hume C, Seiler G, Porat-Mosenco Y, Caceres A, Shofer F, Sorenmo K Cystosonographic measurements of canine bladder tumours. Veterinary and comparative oncology 8: 122-6, 2010.

Jacobs Terry M, Hoppe Bruce R, Poehlmann Cathy E, Ferracone Jackie D, Sorenmo Karin U Mammary adenocarcinomas in three male cats exposed to medroxyprogesterone acetate (1990-2006). Journal of feline medicine and surgery 12: 169-74, 2010.

Krick E L, Little L, Patel R, Shofer F S, Sorenmo K, Clifford C A, Baez J L Description of clinical and pathological findings, treatment and outcome of feline large granular lymphocyte lymphoma (1996-2004). Veterinary and comparative oncology 6: 102-10, 2008.

McNeill C J, Overley B, Shofer F S, Kent M S, Clifford C A, Samluk M, Haney S, Van Winkle T J, Sorenmo K U Characterization of the biological behaviour of appendicular osteosarcoma in Rottweilers and a comparison with other breeds: a review of 258 dogs. Veterinary and comparative oncology 5: 90-8, 2007.

Baez Jennifer L, Michel Kathryn E, Sorenmo Karin, Shofer Frances S A prospective investigation of the prevalence and prognostic significance of weight loss and changes in body condition in feline cancer patients. Journal of feline medicine and surgery 9: 411-7, 2007.

Skorupski Katherine A, Clifford Craig A, Paoloni Melissa C, Lara-Garcia Ana, Barber Lisa, Kent Michael S, LeBlanc Amy K, Sabhlok Aarti, Mauldin Elizabeth A, Shofer Frances S, Couto C Guillermo, Sørenmo Karin U CCNU for the treatment of dogs with histiocytic sarcoma. Journal of veterinary internal medicine 21: 121-6, 2007.

Litster Annette L, Sorenmo Karin U Characterisation of the signalment, clinical and survival characteristics of 41 cats with mast cell neoplasia. Journal of feline medicine and surgery 8: 177-83, 2006.

Heller D A, Clifford C A, Goldschmidt M H, Holt D E, Shofer F S, Smith A, Sorenmo K U Cyclooxygenase-2 expression is associated with histologic tumor type in canine mammary carcinoma. Veterinary pathology 42: 776-80, 2005.

Heller D A, Clifford C A, Goldschmidt M H, Holt D E, Manfredi M J, Sorenmo K U Assessment of cyclooxygenase-2 expression in canine hemangiosarcoma, histiocytic sarcoma, and mast cell tumor. Veterinary pathology 42: 350-3, 2005.

Baez Jennifer L, Hendrick Mattie J, Shofer Frances S, Goldkamp Carrie, Sorenmo Karin U Liposarcomas in dogs: 56 cases (1989-2000). Journal of the American Veterinary Medical Association 224: 887-91, 2004.

Sorenmo Karin U, Baez Jennifer L, Clifford Craig A, Mauldin Elizabeth, Overley Beth, Skorupski Katherine, Bachman Roxanne, Samluk Marissa, Shofer Frances Efficacy and toxicity of a dose-intensified doxorubicin protocol in canine hemangiosarcoma. Journal of veterinary internal medicine 18: 209-13, 2004.

Carreras Janet K, Goldschmidt Micheal, Lamb Martin, McLear Robert C, Drobatz Kenneth J, Sørenmo Karin U Feline epitheliotropic intestinal malignant lymphoma: 10 cases (1997-2000). Journal of veterinary internal medicine 17: 326-31, 2003.

Sorenmo K U, Goldschmidt M, Shofer F, Goldkamp C, Ferracone J Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time. Veterinary and comparative oncology 1: 48-56, 2003.

Clifford Craig A, Hughes Dez, Beal Matthew W, Henry Carolyn J, Drobatz Kenneth J, Sorenmo Karin U Vascular endothelial growth factor concentrations in body cavity effusions in dogs. Journal of veterinary internal medicine 16: 164-8, 2002.

Weisse Chick, Shofer Frances S, Sorenmo Karin Recurrence rates and sites for grade II canine cutaneous mast cell tumors following complete surgical excision. Journal of the American Animal Hospital Association 38: 71-3, 2002.

Langenbach A, McManus P M, Hendrick M J, Shofer F S, Sorenmo K U Sensitivity and specificity of methods of assessing the regional lymph nodes for evidence of metastasis in dogs and cats with solid tumors. Journal of the American Veterinary Medical Association 218: 1424-8, 2001.

Barber L G, Sørenmo K U, Cronin K L, Shofer F S Combined doxorubicin and cyclophosphamide chemotherapy for nonresectable feline fibrosarcoma. Journal of the American Animal Hospital Association 36: 416-21, 2000.

Sorenmo K, Duda L, Barber L, Cronin K, Sammarco C, Usborne A, Goldschmidt M, Shofer F Canine hemangiosarcoma treated with standard chemotherapy and minocycline. Journal of veterinary internal medicine 14: 395-8, 2000.

Hershey A E, Sorenmo K U, Hendrick M J, Shofer F S, Vail D M Prognosis for presumed feline vaccine-associated sarcoma after excision: 61 cases (1986-1996). Journal of the American Veterinary Medical Association 216: 58-61, 2000.

Langenbach A, Anderson M A, Dambach D M, Sorenmo K U, Shofer F D Extraskeletal osteosarcomas in dogs: a retrospective study of 169 cases (1986-1996). Journal of the American Animal Hospital Association 34: 113-20, 1998.

Sorenmo K U, Jeglum K A, Helfand S C Chemotherapy of canine hemangiosarcoma with doxorubicin and cyclophosphamide. Journal of veterinary internal medicine 7: 370-6, 1993.

Lewis John R, O'Brien Thomas G, Skorupski Katherine A, Krick Erika L, Reiter Alexander M, Jennings Michael W, Jurney Carrie H, Shofer F S Polyamine inhibitors for treatment of feline oral squamous cell carcinoma: a proof-of-concept study. Journal of veterinary dentistry 30: 140-5, 2013.

Amrita Sahu, Firdous Saleheen, Vira Oleksyuk, C McGoverin, Nancy Pleshko, Amir Hossein Harati Nejad Torbati, Joseph Picone, Karin U. Sorenmo, Chang-Hee Won Characterization of Mammary Tumors Using Noninvasive Tactile and Hyperspectral Sensors IEEE Sensors Journal 14: 3337-3344, 2014.

Krick E L, Cohen R B, Gregor T P, Salah P C, Sorenmo K U Prospective clinical trial to compare vincristine and vinblastine in a COP-based protocol for lymphoma in cats. Journal of veterinary internal medicine 27: 134-40, 2013.

Clendaniel Daphne C, Sivacolundhu Ramesh K, Sorenmo Karin U, Donovan Taryn A, Turner Avenelle, Arteaga Theresa, Bergman Philip J Association between macroscopic appearance of liver lesions and liver histology in dogs with splenic hemangiosarcoma: 79 cases (2004-2009). Journal of the American Animal Hospital Association 50: e6-10, 2014.

Kristiansen V M, Nødtvedt A, Breen A M, Langeland M, Teige J, Goldschmidt M, Jonasdottir T J, Grotmol T, Sørenmo K Effect of ovariohysterectomy at the time of tumor removal in dogs with benign mammary tumors and hyperplastic lesions: a randomized controlled clinical trial. Journal of veterinary internal medicine 27: 935-42, 2013.

Sorenmo KU, Shofer FS, and Goldschmidt M. Survival in dogs with malignant mammary gland epithelial tumors, effect of spaying and timing of spaying. J Vet Intern Med 14: 266-270, 2000.

Clifford CA, Hughes D, Beal M, Mackin A, Henry CJ, Shofer FS, and Sorenmo KU.* Plasma vascular endothelial growth factor (VEGF) levels in normal dogs and dogs with hemangiosarcoma. J Vet Intern Med 15: 131-135, 2001.

Sorenmo KU, Goldschmidt MH Shofer FS, Goldkamp C, Ferracone J. Evaluation of COX-I and II expression and the effect of cyclooxygenase inhibitiors in canine prostate cancer. Veterinary and Comparative Oncology 2: 13-23, 2004.

Clifford CA, Pretorius SE,, Weisse C, Sorenmo KU, Drobatz, KJ, Siegelman, ES, Solomon JA. Magnetic Resonance Imaging (MRI) of Canine Focal Splenic and Hepatic Lesions. J Vet Intern Med 18: 330-338, 2004.

Michel KE, Sorenmo KU, Shofer FS. Evaluation of dogs presenting to a Veterinary Oncology service for indications of Cancer Cachexia Syndrome. J Vet Intern Med 18: 692-695, 2004.

Skorupski K, Overley B, Shofer FS, Goldschmidt MH, Miller CA, and Sorenmo KU.* Clinical Characteristics of Mammary Carcinoma in the Male Feline. J Vet Intern Med : 52-55, 2005.

Overley B, Shofer, FS, Goldschmidt MG, Sherer D, Haney S, Sorenmo KU.* Association between Ovariohysterectomy (OHE) and Feline Mammary Carcinoma. J Vet Intern Med 19: 560-563, 2005.

Katherine A. Skorupski KA, Durham AC, Duda L, Sørenmo KU.* Pulmonary fibrosis after high cumulative dose nitrosourea chemotherapy in a cat. Veterinary and Comparative Oncology 6(2): 120-5, 2008.

Sorenmo KU, Samluk M, Clifford C, Baez J,. Barrett J, Poppenga R, Overley B, Skorupski K, Oberthaler K, Van Winkle T, Seiler G, Shofer S. Clinical and pharmacokinetic characteristics of intracavitary administration of pegylated liposomal encapsulated doxorubicin in dogs with splenic hemangiosarcoma. J Vet Intern Med 21: 1347-1354, 2007.

Sorenmo K, LaBlanc A, Krick E, Overley B, Colligon T, Shofer F, Coughlin C, Mason N, Vonderheide R. CD40 activated B (CD40-B) cells loaded with autologous tumor RNA as a novel antigen-presenting cell vaccine for cainine lymphoma. 28th Annual Conference of the Veterinary Cancer Society Seattle Washington : , 2008.

Oberthaler KT, Mauldin E, McManus PM, Shofer FS, Sorenmo KU* Rescue therapy with doxorubicin-based chemotherapy for relapsing or refractory feline lymphoma: a retrospective study of 23 cases. J Feline Med Surg. 11(4): 259-65 , 2009.

McNeill CJ, Sorenmo KU, Shofer FS, Gibeon L, Durham AC, Barber LG, Baez JL, Overley B. Evalaution of adjuvant doxorubicin-based chemotherapy for the treatment of feline mammary carcinoma. J Vet Internal Medicine 23(1): 123-9, 2009.

Paolini M, Tandle A, Mazcko C, Hanna E, Kachala S, LeBlanc A, Newman S, Vail D, Henry C, Thamm D, Sorenmo K, Hajitou A, Pasqualini R, Arap W, Khanna C, Libutti S. Launching a novel preclinical infrastructure: Comparative oncology trials consortium directed therapeutic targeting of TNF alpha to cancer vasculature. PLoS ONE 4(3): e4972: , 2009.

Sorenmo KU, Kristiansen V, Cofone MA, Shofer FS, Breen AM, Langeland M, Mongil CM, Grondahl AM, Teige J, Goldschmidt MH. Canine mammary gland tumors; a histological continuum from benign to malignant; clinical and histopathological evidence E.pub 2009 DOI: 10.1111/j.1476-5829 Veterinary and Comparative Oncology DOI: 10.1111/j.1476-5829: , 2009.

Krick E, Billings AP, Shofer FS, Watanabe S, Sorenmo KU* Cytological lymph node evaluation in dogs with mast cell tumors: association with grade and survival. Veterinary and Comparative Oncology. 7(2): 130-8 , 2009 .

Sorenmo KU, Harwood LP, King LG, Drobatz KJ. Risk factors for developing sepsis (neutropenia and fever) in dogs undergoing chemotherapy; a retrospective case-control study, JAVMA : , 2009.

The Norwegian College of Veterinary Medicine, Oslo, Norway, 1983

Mare Agricultural School, 1977

Ytre Namdal videregaende skole (High School), 1976