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Recent Grant News

  • Grant: Tumor-permissive Collagen Signatures in Canine Mammary Gland Tumors: Development of Prognostic Markers and Targeted Therapies for Improved Outcomes
  • Granting Agency: American Kennel Club Canine Health Foundation
  • Principal Investigator: Susan Volk, VMD, PhD
  • Co-Investigators: Karin Sorenmo, DVM; Ellen Puré, PhD
  • Grant Amount: $162,700.00
  • Study Duration: 3/1/2018 - 2/29/2020
  • Summary: Mammary gland tumors (MGT) represent the most common malignancies in intact female dogs and as such represent a significant health problem resulting in premature death and morbidity in this sub-population of dogs. Our recently published study supports a key role for collagen in the tumor microenvironment to direct biologic behavior of canine mammary carcinoma. The objective of this study is to identify additional collagen signatures that predict recurrence and clinical outcome in dogs with MGT and perform proof-of-principle studies to determine if collagen-directed therapies will be effective for dogs at high-risk for recurrence.

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