Penn Vet | Fact Sheet Detail




By: Wildlife Futures Team Date: Dec 16, 2020


Aspergillosis is an infectious disease of birds and mammals caused by the fungi in the Aspergillus group. While this disease can affect wild mammals, it is more common in birds, so birds will be the focus of this disease description. The Aspergillus genus was first described in 1729, and it was first recognized to cause disease in wild birds in the early 1800’s. 


Aspergillus fungi are almost everywhere in the environment and can cause disease in wild and domestic animals, as well as humans. However, the disease is not contagious, meaning it cannot be transmitted from animal to animal nor can it be transmitted from infected animals to humans. Most human cases of aspergillosis occur in those who have some deficiency of their immune system (children, the elderly, those taking immune suppressing drugs, and those with diseases that suppress their immune function). The same is true for birds. For example, lead toxicity, which suppresses and weakens the immune system can predispose bald eagles (and other species) to aspergillosis. Outbreaks of aspergillosis in wild birds may be associated with outbreaks in domestic birds if they have access to a common source of the fungus. In wild populations, outbreaks of aspergillosis can result in high mortality. Aspergillosis can also be a problem in wild birds that are kept in captivity. 

Species Affected

All species of birds (wild and domestic) are considered susceptible to aspergillosis, although the majority of reported cases occur in raptors, waterfowl, and gulls. Many species of domestic (cows, horses, sheep, pigs, etc.) and wild (elk, bison, hares, deer, etc.) mammals have been reported with this disease, but the cases are sporadic and it is not a major concern for populations. Humans can be infected.


With the exception of Antarctica, Aspergillus fungi are found worldwide and is frequently diagnosed in a variety of avian species throughout New England. It lives in soil and decaying animal, plant and feed material, especially decaying seeds, feeds, grains, peanuts, cereal, and vegetables.


Aspergillosis is primarily transmitted via inhalation of fungal spores. The fungus can produce a tremendous number of spores when in a warm and moist environment. Healthy birds and mammals can inhale a certain number of spores without becoming ill. For example, studies show that day old chicks must inhale about 6 million spores to become fatally sick, while adult birds must inhale 17 million spores to produce fatal illness. Some more susceptible species may require a lower dose to produce fatal illness. Oral ingestion of spores is unlikely to cause serious disease, but aspergillosis can be transmitted when spores are introduced to the body in puncture wounds. Aspergillus spores are capable of penetrating eggshells and can result in embryonic death or hatching of infected chicks.

Outbreaks are more likely to occur when populations that flock together in high densities such as during migrations are exposed to a common source of Aspergillus. Sporadic cases of individuals with aspergillosis also occur in the wild but are more likely to go unnoticed. Most outbreaks in waterfowl occur in the fall and early winter. All birds are more susceptible to aspergillosis in times of stress or reduced immune function. For example, birds that are malnourished, oiled, captured and placed in captivity, overcrowded, or suffering from another disease condition are more likely to develop clinical aspergillosis. Poor living conditions in captivity, such as poor ventilation and sanitation, high humidity and temperature, and old bird feed, can increase the concentration of Aspergillus spores and thus increase the chances of an aspergillosis outbreak within a captive flock. 

Clinical Signs

Aspergillosis can cause acute or chronic illness. Birds that are acutely infected will die quickly from respiratory distress. These birds may exhibit lethargy, dehydration, loss of appetite, diarrhea, and may be gasping for breath before they die. Some birds may be found dead without observation of clinical signs. Acute infections are more common in younger birds, while older birds are more prone to chronic, slowly progressive disease. Chronically infected birds may exhibit loss of body condition, lethargy, loss of appetite, difficulty flying and breathing, vomiting, and diarrhea. They may also show signs of neurological disease. Many organ systems can be affected, but aspergillosis usually targets the respiratory system. Once the fungus becomes established, it produces poisonous substances or toxins which can damage various tissues. At necropsy, chronically infected birds will have cheese-like yellow or white plaques or nodules in their lungs, air sacs, and other organs such as the liver. They may also have fungus growing on respiratory tissues that resembles bread mold. Acutely infected birds are more likely to have firm, dark red lungs with small yellow nodules scattered throughout.


Several laboratory tests and microscopic evaluation can be used to identify the Aspergillus fungus.


Treatment of aspergillosis is often not effective, but topical or injected anti-fungal drugs can be used to treat captive domestic or wild birds. Treatment can also include removal of the lesions and supportive care. Treatment of free-ranging wild birds is not feasible.


Aspergillus occurs naturally almost everywhere in soil, so it cannot be eliminated from the environment. However, wild bird populations often experience aspergillosis outbreaks as a result of discarded moldy grain, rice, or corn from agricultural areas. Access to sources of moldy agricultural waste should be eliminated. Bird feeders can also be a potential source of aspergillosis exposure for wild birds, so it is important to ensure that seed in feeders is fresh and free of mold. Large captive bird populations should not be overcrowded and should be kept in clean areas with proper ventilation and temperature and humidity control. People working with dense colonies of wild or domestic birds should wear facemasks especially in the presence of wet feed, litter, or feces. People should also wear facemasks when conducting necropsies of birds if aspergillosis is suspected. Hunters should not consume birds with this disease because although the disease cannot be transmitted by eating the meat of an infected bird, hunters can be exposed by inhalation of spores from carcasses.

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