Penn Vet | Clinical Trial Detail - CHRONIC DIARRHEA - New Study for Dogs with Chronic Gastrointestinal Upset
New Bolton Center Kennett Square, PA
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Ryan Hospital Philadelphia, PA

CHRONIC DIARRHEA - New Study for Dogs with Chronic Gastrointestinal Upset

Jul 16, 2014

Penn Vet is currently enrolling dogs with clinical signs of Canine Chronic Enteropathy (CCE) in a clinical trial aiming to determine the composition of the microbiome (the naturally occurring  bacteria) of the gastrointestinal tract before, during and after treatment.  CCE is a common syndrome in dogs, resulting in clinical signs such as diarrhea, vomiting and weight loss.

The duration and severity of these symptoms vary, as does response to treatment, suggesting that there are multiple forms and causes of this disease.  Common causes include food sensitivity and inflammatory bowel disease (IBD).  The microbiome--an ecosystem of bacteria living in the intestine--has been shown to be important in human inflammatory bowel disease.  Understanding how these  bacteria change in dogs being treated for CCE may lead to better diagnostics and treatments for inflammatory diseases in pets.

Dogs enrolled in this study will receive the standard of care treatment for CCE for up to 8 weeks.  During that time, stool samples will be collected in order to analyze the microbiome of the GI tract.  The study requires a minimum of four visits to Penn Vet and the collection of stool samples at home.


  • Diarrhea and/or vomiting for at least 3 weeks.


  • All standard of care diagnostics used to determine whether your dog has CCE (physical exam, blood work, urinalysis, fecal screening, abdominial ultrasound, and endoscopy
  • Standard treatment for CCE for up to 8 weeks

To Enroll

For more information, please contact the VCIC at 215-573-0302 or email