Evaluation of Epidemiological Factors and Laboratory Data in Dogs with Tooth Resorption

The goal of this study is to better characterize tooth resorption (resorption of multiple permanent teeth) in dogs and to investigate the possible role of calciotropic hormones in the development of this disease by evaluating prevalance, signalment, laboratory data and possible risk factors both retrospectively and prospectively. The prospective part includes recruitment of client-owned dogs with and without tooth resorption. All patients enrolled in the study will receive an anesthetized oral examination, and dental radiographs will be obtained. Blood samples will be collected for evaluation of a complete blood count, chemistry screen, and serum calciotropic hormones (ionized calcium, parathyroid hormone, and 25-hydroxyvitamin D). Free-catch urine samples will be collected for evaluation of renal function (routine urinalysis, protein to creatinine ratio and assessment of microalbuminuria). Information about medical history and feeding management will be obtained from the owner. Dogs enrolled in this study will receive free of charge:

  • One urinalysis (including sediment analysis) and protein:creatinine ratio (test for kidney health)
  • One urine screening test for microalbuminuria (test for early kidney disease)
  • One serum 25-hydroxyvitamin D, parathyroid hormone, and ionized calcium measurement (tests to evaluate calcium metabolism)

This study has been reviewed and approved by the University of Pennsylvania Institutional Animal Care and Use Committee (IACUC) for privately owned animals. Please contact Dr. Alex Reiter of the Dentistry and Oral Surgery Service at (215) 573-6539 or reiter@vet.upenn.edu.